Real-time UV imaging of drug diffusion and release from Pluronic F127 hydrogels

Ye, Fengbin; Yaghmur, Anan; Jensen, Henrik; Larsen, Susan Weng; Larsen, Claus; Østergaard, Jesper

doi:10.1016/j.ejps.2011.04.015

Cited by 69 publications

(45 citation statements)

References 46 publications

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“…Hydrogel Characterisation of drug release and transport in hydrogels 2011 [85] Amlodipine, amlodipine besylate (amorphous and dihydrate forms)…”

Section: Piroxicammentioning

confidence: 99%

Analytical technologies for real-time drug dissolution and precipitation testing on a small scale

Kuentz

2014

Journal of Pharmacy and Pharmacology

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Objectives This review focuses on real-time analytics of drug dissolution and precipitation testing on a comparatively small scale. Key findings Miniaturisation of test equipment is an important trend in pharmaceutics, and several small-scale experiments have been reported for drug dissolution and precipitation testing. Such tests typically employ analytics in realtime. Fibre optic ultraviolet (UV) analytics has become a well-established method in this field. Novel imaging techniques are emerging that use visible or UV light; also promising is Fourier transform infrared imaging based on attenuated total reflection. More information than just a rate constant is obtained from these methods. The early phase of a dissolution process can be assessed and drug precipitation may eventually be observed. Some real-time techniques are particularly well suited to studying drug precipitation during formulation dispersion; for example, turbidity, focused beam reflectance measurement and Raman spectroscopy. Summary Small-scale dissolution tests equipped with real-time analytics have become important to screen drug candidates as well as to study prototype formulations in early development. Future approaches are likely to combine different analytical techniques including imaging. Miniaturisation started with mini-vessels or small vials and future assays of dissolution research will probably more often reach the level of parallel well plates and microfluidic channels.

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“…Hydrogel Characterisation of drug release and transport in hydrogels 2011 [85] Amlodipine, amlodipine besylate (amorphous and dihydrate forms)…”

Section: Piroxicammentioning

confidence: 99%

Analytical technologies for real-time drug dissolution and precipitation testing on a small scale

Kuentz

2014

Journal of Pharmacy and Pharmacology

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“…This study indicates that UV imaging has great potential for measuring drug diffusion in and release from gel matrices. Compared to the currently used conventional techniques, this technology has several advantages including high information content, non-intrusive measurements without the need for labeling, flexibility with respect to experimental design and simplicity of operation [12].…”

Section: Delivery Of Small Moleculesmentioning

confidence: 99%

“…Various hydrogel formulations loaded with poorly water-soluble piroxicam for transdermal delivery has been investigated by some researchers [11,12,15]. The pharmacokinetics and anti-inflammatory activity of piroxicam from Poloxamer 407 gel were determined to investigate percutaneous absorption of piroxicam from poloxamer gels in rats; Poloxamer 407 gel containing 1 % piroxicam showed significant inhibition of carragenin-induced rat foot swelling (%) with a linear relationship of piroxicam dose within ~0.4 -3.2 mg/kg when compared to the control group (Figure 1).…”

Section: Delivery Of Small Moleculesmentioning

confidence: 99%

“…Studies on PEO-PPO-based polymeric micelles for transdermal drug delivery have been widely carried out with Poloxamer 407 (Pluronic F127) and these studies mostly focused on small drug molecules in order of anti-inflammatory [8][9][10][11][12][13][14][15][16][17][18][19], analgesic [20], local anesthetic [21] and cardiac effectiveness [19,[22][23][24] and rarely focused on big molecules such as arginine vasopressin (AVP) and insulin [25,26].…”

Section: Peo-ppo Based Copolymers In Transdermal Drug Deliverymentioning

confidence: 99%

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Poly(ethylene oxide)–Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview

Yapar¹,

Ýnal²

2013

Trop. J. Pharm Res

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“…(3,4) There are different approaches to measuring the two-dimensional distribution of UV light or UV images. One approach is to use a recording medium that records the distribution of UV light intensity in a two-dimensional area in the form of a UV-induced effect.…”

Section: Introductionmentioning

confidence: 99%

Photochromism and Thermally and Optically Stimulated Luminescences of AlN Ceramic Plate for UV Sensing

2016

Sensors and Materials

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We have characterized AlN ceramic plates (SHAPAL ® , Tokuyama Corporation, Japan) for UV sensing applications. The SHAPAL ® AlN ceramic plate is a commercially available product used as a heat sink, but it shows photochromic effects and thermally and optically stimulated luminescences (TSL and OSL) after it is exposed to UV light. Upon UV exposure, a broad optical absorption band is induced in the UV-blue region (2.5-4.5 eV), and the color changes from gray to orange. A UVexposed AlN ceramic plate emits near UV light (~3.4 eV) upon thermal or optical stimulation. The TSL signal showed maximum intensity when heated to around 200 °C, whereas the OSL could be stimulated by light exposure over a wide spectral range from ~2 to 3 eV. The sensitivity of the photochromism, TSL, and OSL depended on the UV photon energy. Overall, these UV-induced effects were strongly pronounced for photon energies higher than 4.0 eV, but the photochromic effect could be seen for lower energies, though the signal was considerably smaller. The AlN ceramic plate could be used for UV sensing multiple times. The photochromic, TSL, and OSL signals could be erased by heat treatment, and the OSL signal could also be erased by exposure to low-energy light.

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Real-time UV imaging of drug diffusion and release from Pluronic F127 hydrogels

Cited by 69 publications

References 46 publications

Analytical technologies for real-time drug dissolution and precipitation testing on a small scale

Analytical technologies for real-time drug dissolution and precipitation testing on a small scale

Poly(ethylene oxide)–Poly(propylene oxide)-Based Copolymers for Transdermal Drug Delivery: An Overview

Photochromism and Thermally and Optically Stimulated Luminescences of AlN Ceramic Plate for UV Sensing

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