Real-Time Strain Rate Imaging of the Left Ventricle by Ultrasound

Heimdal, Andreas; Støylen, Asbjørn; Torp, Hans; Skjærpe, Terje

doi:10.1016/s0894-7317(98)70151-8

Cited by 769 publications

(494 citation statements)

References 17 publications

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“…4 Strain rate imaging, a new technique based on ultrasonic Doppler myocardial imaging, quantifies changes in regional myocardial deformation very precisely. 5 A recent report has shown that Doppler myocardial imaging can detect reduced myocardial function even before LV hypertrophy in patients with Fabry disease occurs. 4 Thus, in the present study, we sought to determine whether ERT can reduce myocardial hypertrophy and whether strain rate imaging can detect an improvement of myocardial function after 12 months of therapy.…”

mentioning

confidence: 99%

Improvement of Cardiac Function During Enzyme Replacement Therapy in Patients With Fabry Disease

Weidemann¹,

Breunig²,

Beer³

et al. 2003

Circulation

344

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Background-Enzyme replacement therapy (ERT) has been shown to enhance microvascular endothelial globotriaosylceramide clearance in the hearts of patients with Fabry disease. Whether these results can be translated into an improvement of myocardial function has yet to be demonstrated. Methods and Results-Sixteen patients with Fabry disease who were treated in an open-label study with 1.0 mg/kg body weight of recombinant ␣-Gal A (agalsidase ␤, Fabrazyme) were followed up for 12 months. Myocardial function was quantified by ultrasonic strain rate imaging to assess radial and longitudinal myocardial deformation. End-diastolic thickness of the left ventricular posterior wall and myocardial mass (assessed by magnetic resonance imaging, nϭ10) was measured at baseline and after 12 months of ERT. Data were compared with 16 age-matched healthy controls. At baseline, both peak systolic strain rate and systolic strain were significantly reduced in the radial and longitudinal direction in patients compared with controls. Peak systolic strain rate increased significantly in the posterior wall (radial function) after one year of treatment (baseline,

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mentioning

confidence: 99%

Improvement of Cardiac Function During Enzyme Replacement Therapy in Patients With Fabry Disease

Weidemann¹,

Breunig²,

Beer³

et al. 2003

Circulation

344

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“…Recently, a new algorithm that calculates strain from Doppler tissue velocities has been developed (myocardial strain imaging) [12]. A previous study has demonstrated that strain measurements derived from this Doppler algorithm correlated well with those obtained by invasive sonomicrometry [13].…”

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confidence: 99%

Quantitative Assessment of Wall Motion Using Myocardial Strain

et al. 2003

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Background: Since regional tissue velocities are affected by motion of the adjacent regions as well as the whole heart translational motion, the quantification of wall motion using conventional tissue Doppler method may be questionable.Recently, a new echocardiographic system which enables the calculation of myocardial strain based on tissue Doppler information has been developed. Methods:We investigated whether myocardial strain could quantify regional myocardial contraction in 13 patients with normal wall motion and in 18 patients with wall motion abnormalities. Left ventricular segmental wall motion was assessed with conventional 2-dimensional echocardiography at the apical 2-, 3-, and 4-chamber views. The same views were imaged also with tissue Doppler method to determine regional systolic myocardial strain.Results: By 2-dimensional echocardiography, 230 segments were judged normokinesis, 83 segments hypokinesis and 23 segments showed akinesis. No segments showed dyskinesis. Peak systolic strain values of normokinetic, hypokinetic and akinetic wall segments were significantly different from each other (-20.1±5.5% for normokinesis, -11.9±5.0% for hypokinesis, p<0.0001 vs. normokinesis, and -6.3±3.4% for akinesis, p<0.0001 vs. normokinesis and p<0.0001 vs. hypokinesis) without significant overlap. Peak systolic strain values in normal subjects were similar among all segments, suggesting insignificant regional variations (p=ns). Conclusion:Systolic myocardial strain agreed well with assessed wall motion. Myocardial strain imaging may be a new powerful tool to quantify regional wall contraction. (J Echocardiogr 2003; 1: 23-28)

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“…11 Color-coded TDI has facilitated quantitative assessment of ventricular wall motion, [12][13][14][15][16][17][18] so it would be helpful if the presence of PSS was made readily visible by this technique without the need for mapping. In the present study, we aimed to develop a color-coded TDI technique that detects PSS on 2-dimensional (D) echocardiograms: detection of diastolic abnormality by dyssynchrony imaging (DADI).…”

Section: Editorial P 37mentioning

confidence: 99%

Detection of Diastolic Abnormality by Dyssynchrony Imaging Correlation With Coronary Artery Disease in Patients Presenting With Visibly Normal Wall Motion

Onishi

Uematsu

Nanto

et al. 2009

Circ J

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Background Post-systolic shortening (PSS) is a sensitive indicator of myocardial ischemia. Methods and ResultsWe have developed a tissue Doppler imaging technique that portrays PSS, and whether PSS correlates with coronary artery disease (CAD) was investigated in 186 patients presenting with chest pain and normal echocardiograms. Delays of the displacement peaks from end-systole were calculated in the apical views and displayed from green (0 ms) to red (≥100 ms): detection of diastolic abnormality by dyssynchrony imaging (DADI). CAD was judged positive by DADI when the left ventricular segments were color-coded red. Patients subsequently underwent thallium-201 myocardial perfusion single-photon emission computed tomography (n=150), coronary angiography (CAG, n=74), or both (n=37). CAD(-) was defined as negative scintigraphy test and/or no significant coronary artery stenosis by CAG. In 43 patients (23%), CAD(+) was confirmed by CAG as >75% diameter stenosis. DADI predicted CAD with sensitivity of 60%, specificity of 75%, predictive accuracy of 72%, positive predictive value of 42%, and negative predictive value of 86%. Among 74 patients who underwent CAG, sensitivity was best for the left anterior descending artery. Conclusions DADI detected the regional diastolic abnormality, which correlated with the presence of CAD in patients presenting with visibly normal wall motion. (Circ J 2009; 73: 125 -131)

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Real-Time Strain Rate Imaging of the Left Ventricle by Ultrasound

Cited by 769 publications

References 17 publications

Improvement of Cardiac Function During Enzyme Replacement Therapy in Patients With Fabry Disease

Improvement of Cardiac Function During Enzyme Replacement Therapy in Patients With Fabry Disease

Quantitative Assessment of Wall Motion Using Myocardial Strain

Detection of Diastolic Abnormality by Dyssynchrony Imaging Correlation With Coronary Artery Disease in Patients Presenting With Visibly Normal Wall Motion

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