Real-time Spectral Tracking Routine for Fluorescence Hyperspectral Guidance in Breast Conserving Surgery

Leiloglou, Maria; Gkouzionis, Ioannis; Kedrzycki, Martha; Cartucho, João; Chalau, Vadzim; Darzi, Ara; Leff, Daniel; Elson, Daniel S.

doi:10.1364/boda.2021.df1a.3

Cited by 1 publication

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Image reproduced with the permission of publisher. 18 FGS used in cancers) through citation tracking. The full search strategy can be found in the Appendix.…”

Section: Strategy For Identification and Selection Of Studiesmentioning

confidence: 99%

Fluorescence guided surgery imaging systems for breast cancer identification: a systematic review

Kedrzycki,

Chon,

Leiloglou

et al. 2024

J. Biomed. Opt.

Self Cite

View full text Add to dashboard Cite

Breast-conserving surgery (BCS) is limited by high rates of positive margins and re-operative interventions. Fluorescence-guided surgery seeks to detect the entire lesion in real time, thus guiding the surgeons to remove all the tumor at the index procedure.Aim: Our aim was to identify the optimal combination of a camera system and fluorophore for fluorescence-guided BCS.Approach: A systematic review of medical databases using the terms "fluorescence," "breast cancer," "surgery," and "fluorescence imaging" was performed. Cameras were compared using the ratio between the fluorescent signal from the tumor compared to background fluorescence, as well as diagnostic accuracy measures, such as sensitivity, specificity, and positive predictive value.Results: Twenty-one studies identified 14 camera systems using nine different fluorophores. Twelve cameras worked in the infrared spectrum. Ten studies reported on the difference in strength of the fluorescence signal between cancer and normal tissue, with results ranging from 1.72 to 4.7. In addition, nine studies reported on whether any tumor remained in the resection cavity (5.4% to 32.5%). To date, only three studies used the fluorescent signal for guidance during real BCS. Diagnostic accuracy ranged from 63% to 98% sensitivity, 32% to 97% specificity, and 75% to 100% positive predictive value. Conclusion:In this systematic review, all the studies reported a clinically significant difference in signal between the tumor and normal tissue using various camera/ fluorophore combinations. However, given the heterogeneity in protocols, including camera setup, fluorophore studied, data acquisition, and reporting structure, it was impossible to determine the optimal camera and fluorophore combination for use in BCS. It would be beneficial to develop a standardized reporting structure using similar metrics to provide necessary data for a comparison between camera systems.

show abstract

“…Image reproduced with the permission of publisher. 18 FGS used in cancers) through citation tracking. The full search strategy can be found in the Appendix.…”

Section: Strategy For Identification and Selection Of Studiesmentioning

confidence: 99%

Fluorescence guided surgery imaging systems for breast cancer identification: a systematic review

Kedrzycki,

Chon,

Leiloglou

et al. 2024

J. Biomed. Opt.

Self Cite

View full text Add to dashboard Cite

show abstract

Real-time Spectral Tracking Routine for Fluorescence Hyperspectral Guidance in Breast Conserving Surgery

Abstract: Fast spectral tracking routine, using simultaneous analysis of color and monochrome images, was developed and tested in phantoms. This routine could improve the efficiency of fluorescence hyperspectral imaging for breast conserving surgery guidance. © 2021 The Author(s)

Cited by 1 publication

References 5 publications

Fluorescence guided surgery imaging systems for breast cancer identification: a systematic review

Fluorescence guided surgery imaging systems for breast cancer identification: a systematic review

Contact Info

Product

Resources

About