Real-time shear-wave elastography: Applicability, reliability and accuracy for clinically significant portal hypertension

Procopeţ, Bogdan; Berzigotti, Annalisa; Abraldes, Juan G.; Turón, Fanny; Hernández‐Gea, Virginia; García‐Pagán, Juan Carlos; Bosch, Jaime

doi:10.1016/j.jhep.2014.12.007

Cited by 203 publications

(234 citation statements)

References 18 publications

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“…HVPG measurement is recommended to all patients newly diagnosed with cirrhosis for the evaluation of risk and establishment of prognosis [17] and is also a good tool to monitor the response to treatment and achievement of endpoints (over 20% HVPG decrease as compared to baseline and/or HVPG < 12 mmHg) [17] . Both liver stiffness and spleen stiffness have shown to be predictors for detecting PH [18][19][20][21] . Liver stiffness measurement (LSM) has a good correlation with HVPG r = 0.81, P < 0.0001 when using TE [18] , and r = 0.611, P < 0.0001 with SWE [20] .…”

Section: Prediction Of Phmentioning

confidence: 99%

“…Both liver stiffness and spleen stiffness have shown to be predictors for detecting PH [18][19][20][21] . Liver stiffness measurement (LSM) has a good correlation with HVPG r = 0.81, P < 0.0001 when using TE [18] , and r = 0.611, P < 0.0001 with SWE [20] . One study that compared LS with spleen stiffness (SS) assessed both by SWE found that the diagnostic performance of LSM was significantly better than that of SS for the diagnosis of clinically significant PH (area under the receiver operating characteristic curve of 0.87 vs 0.64, P = 0.003).…”

Section: Prediction Of Phmentioning

confidence: 99%

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Liver ultrasound elastography: More than staging the disease

Gherlan¹

2015

WJH

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Ultrasound elastography is perhaps the most important breakthrough in the evolution of ultrasonography in the last 15 years. Since transient elastography was introduced, many other methods have been developed and became more and more widely available. The value of ultrasound elastography in staging a chronic liver disease has been established by numerous studies. There have been many studies that have shown that using liver elastography it is possible to predict the presence of the complications of cirrhosis: portal hypertension, presence of esophageal varices (and even their risk of bleeding) and hepatocellular carcinoma. It has been shown that liver elastography can predict the progression of liver fibrosis and also the survival (hepatic events -free) of the patients with chronic liver diseases. These are the real quests of the clinicians, this is the ultimate scope of any medical investigationto predict the outcome of a patient and to help making therapeutic decisions. I brought together only a small amount of the data that has already been written on this subject to support my affirmation that liver ultrasound elastography is more than a tool for staging the liver disease, but it is also comparable to a crystal ball which in the hands of a skilled clinician can reveal the future of the patient and can help to improve this future.

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Section: Prediction Of Phmentioning

confidence: 99%

Section: Prediction Of Phmentioning

confidence: 99%

Liver ultrasound elastography: More than staging the disease

Gherlan¹

2015

WJH

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“…7 In order to assess the utility of RT-SWE for diagnosing portal hypertension, Procopet and colleagues conducted a prospective trial of RT-SWE LS and SS measurements among patients referred for clinically indicated HVPG measurement (with or without transjugular liver biopsy). 1 Of 112 consecutive patients screened, 88 met inclusion criteria (patients with acute hepatitis, noncirrhotic ascites, suspected sinusoidal obstruction syndrome, and liver allograft rejection were excluded). Among the subjects included, the majority had compensated chronic liver disease with or without cirrhosis (55 subjects), 24 had decompensated cirrhosis (of whom 20 had ascites), and nine with hepatic metastases at presurgical evaluation were included as controls.…”

Section: The Shear Effort Of Measurement Of Portal Hypertensionmentioning

confidence: 99%

“…A decades-old first-generation antihistamine drug, chlorcyclizine, was recently reported to possess potent anti-HCV activity in vivo in chimeric mice engrafted with primary human hepatocytes. 1 Chlorcyclizine inhibits a late stage of HCV entry through a yet-to-be identified mechanism. The antiviral effect of chlorcyclizine is synergistic with existing HCV therapies, including ribavirin, interferona, and inhibitors of viral replication, bolstering its potential as a member of combination anti-HCV therapeutic regimens.…”

Section: The Shear Effort Of Measurement Of Portal Hypertensionmentioning

confidence: 99%

The shear effort of measurement of portal hypertension

Sánchez

Kamath

2015

Hepatology

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“…Se ha implementado en un sistema de ultrasonido el Aixplorer ® , que proporciona una imagen bidimensional, cuantitativa y de color de la rigidez del tejido hepático en tiempo real. El supersonic es una prueba no invasiva que determina la elasticidad del hígado y calcula el grado de fibrosis hepática; en algunas ocasiones, reemplaza la toma de la biopsia hepática y es útil para el seguimiento de la mayoría de pacientes con hepatopatías (11)(12)(13)(14).…”

Section: Introductionunclassified

Elastografía en tiempo real (supersonic): comportamiento de la prueba en sujetos sanos de Bogotá

Ortiz

Pardo

Ortíz

et al. 2017

Rev. Colomb. Gastroenterol.

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Introducción: La elastografía en tiempo real (Supersonic), es una prueba no invasiva que se utiliza para determinar la elasticidad del hígado y de esa forma calcular el grado de fibrosis hepática; en algunas ocasiones reemplaza la toma de la biopsia hepática y es útil para el seguimiento de la mayoría de pacientes con hepatopatías. En Colombia, la prueba se introdujo recientemente y no existen hasta el momento estudios del comportamiento de la prueba en personas sanas.Objetivo: Evaluar el comportamiento de la elastografía en tiempo real en sujetos sanos en Bogotá Materiales y métodos: Estudio piloto retrospectivo de sujetos sanos entre 15 y 37 años, entre el 1 de junio de 2016 y el 31 de marzo del 2017. Se realizaron la historia clínica y la evaluación básica de la función hepática para descartar anormalidades. Resultados: La serie incluyó 33 sujetos sanos, 60,6 % mujeres y 39,4 % hombres con una edad promedio de 24,8 años. Al practicar la prueba se encontró un valor promedio de 4,28 kilopascales (kPs), con una diferencia mínima entre sexos, siendo mayor la rigidez hepática en los hombres.Conclusiones: Los valores promedio de la rigidez hepática en 33 sujetos sanos en Bogotá son los mismos reportados en los estudios iniciales de las pruebas a nivel internacional, estos hallazgos sugieren que la prueba puede ser muy útil en nuestro medio para la evaluación de pacientes con hepatopatías.

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Real-time shear-wave elastography: Applicability, reliability and accuracy for clinically significant portal hypertension

Cited by 203 publications

References 18 publications

Liver ultrasound elastography: More than staging the disease

Liver ultrasound elastography: More than staging the disease

The shear effort of measurement of portal hypertension

Elastografía en tiempo real (supersonic): comportamiento de la prueba en sujetos sanos de Bogotá

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