Real-time optimization to enhance noninvasive cortical excitability assessment in the human dorsolateral prefrontal cortex
Sara Parmigiani,
Christopher C. Cline,
Manjima Sarkar
et al.
Abstract:ObjectiveWe currently lack a robust noninvasive method to measure prefrontal excitability in humans. Concurrent TMS and EEG in the prefrontal cortex is usually confounded by artifacts. Here we asked if real-time optimization could reduce artifacts and enhance a TMS-EEG measure of left prefrontal excitability.MethodsThis closed-loop optimization procedure adjusts left dlPFC TMS coil location, angle, and intensity in real-time based on the EEG response to TMS. Our outcome measure was the left prefrontal early (2… Show more
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