Real-time MR-guided brain biopsy using 1.0-T open MRI scanner

He, Xijing; Liu, Ming; Liu, Chao; Fang, Jing; Xu, Yanjun; Wang, Ligang; Xiang, Jianfeng; Sequeiros, Roberto Blanco; Li, Chengli

doi:10.1007/s00330-018-5531-y

Cited by 7 publications

(3 citation statements)

References 28 publications

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“…MR has excellent capabilities of soft tissue contrast, functional imaging and multi-planar imaging. It has significant advantages in target determination, intraoperative guidance and monitoring in craniocerebral surgery [16]. Therefore, in this study, we used a novel 3DNPT combined with open MR guidance in order to explore a new technique of 125 I seed implantation for dose standardization, effectiveness, and a relatively easier procedure in the treatment of recurrent glioblastoma.…”

Section: Introductionmentioning

confidence: 99%

A novel three-dimensional template combined with MR-guided 125I brachytherapy for recurrent glioblastoma

Liu

Zhang

et al. 2020

Radiat Oncol

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Background: At present, the treatment of recurrent glioblastoma is extremely challenging. In this study, we used a novel three-dimensional non-coplanar template (3DNPT) combined with open MR to guide 125 I seed implantation for recurrent glioblastoma. The aim of this study was to evaluate the feasibility, accuracy, and effectiveness of this technique.Methods: Twenty-four patients of recurrent glioblastoma underwent 3DNPT with open MR-guided 125 I brachytherapy from August 2017 to January 2019. Preoperative treatment plan and 3DNPT were made according to enhanced isovoxel T1-weighted MR images. 125 I seeds were implanted using 3DNPT and 1.0-T open MR imaging guidance. Dosimetry verification was performed after brachytherapy based on postoperative CT/MR fusion images. Preoperative and postoperative dosimetry parameters of D90, V100, V200, conformity index (CI), external index (EI) were compared. The objective response rate (ORR) at 6 months and 1-year survival rate were calculated. Median overall survival (OS) measured from the date of brachytherapy was estimated by Kaplan-Meier method. Results: There were no significant differences between preoperative and postoperative dosimetry parameters of D90, V100, V200, CI, EI (P > 0.05). The ORR at 6 months was 75.0%. The 1-year survival rate was 58.3%. Median OS was 12.9 months. One case of small amount of epidural hemorrhage occurred during the procedure. There were 3 cases of symptomatic brain edema after brachytherapy treatment, including grade three toxicity in 1 case and grade two toxicity in 2 cases. The three patients were treated with corticosteroid for 2 to 4 weeks. The clinical symptoms related to brain edema were significantly alleviated thereafter. Conclusions: 3DNPT combined with open MR-guided 125 I brachytherapy for circumscribed recurrent glioblastoma is feasible, effective, and with low risk of complications. Postoperative dosimetry matched the preoperative treatment plan. The described method can be used as a novel implantation technique for 125 I brachytherapy in the treatment of recurrent gliomas.

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Section: Introductionmentioning

confidence: 99%

A novel three-dimensional template combined with MR-guided 125I brachytherapy for recurrent glioblastoma

Liu

Zhang

et al. 2020

Radiat Oncol

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“…This retrospective study received approval from our institutional review board. We have utilized MR in guidance of biopsy procedures and 125 I brachytherapy for brain tumor from 2014 [ 14 , 15 ]. Sixteen cases, including 2 brain metastases and 14 gliomas, were entered into the study.…”

Section: Methodsmentioning

confidence: 99%

CT-MR Image Fusion for Post-Implant Dosimetry Analysis in Brain Tumor Seed Implantation- a Preliminary Study

et al. 2022

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Purpose. To calculate and evaluate postimplant dosimetry (PID) with CT-MR fusion technique after brain tumor brachytherapy and compare the result with CT-based PID. Methods and Materials. 16 brain tumor patients received MR-guided intervention with Iodine-125 (125I) seed implantation entered this preliminary study for PID evaluation. Registration and fusion of CT and MR images of the same patients were performed one day after operation. Seeds identification and targets delineation were carried out on CT, MR, and CT-MR fusion images, each. The number and location of seeds on MR or CT- MR fusion images were compared with those of actually implanted seeds. Clinical target volume (CTV) and dosimetric parameters such as %D90, %V100 and external V100 were measured and calculated. In addition, the correlation of the fusion to CT CTV ratio and other factors were analyzed. Results. The numbers of fusion seeds were not significantly different compared with reference seeds (t =1.76, p >0.05). The difference between reference seeds numbers and truly extracted MR seeds numbers was statistically significant (t =3.91, p <0.05). All dosimetric parameters showed significant differences between the two techniques (p <0.05). The mean CTV delineated on fusion images was 34.3 ± 33.6, smaller than that on CT images. The mean values of external V100, %V100 and %D90 on fusion images were larger than those on CT images. Correlation analysis showed that the fusion-CT V100 ratio was positively and significantly correlated with the fusion-CT volume ratio. Conclusions. This preliminary study indicated that CT-MR fusion-based PID exhibited good accuracy for 125I brain tumor brachytherapy dosimetry when compared to CT-based PID and merits further research to establish best-outcome protocols.

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“…Real-time guidance and visualization are crucial for robot-assisted surgery, especially in neurosurgery, where accurate positioning and delicate interventions are essential 1 , 2 . These include brain biopsy 3 , ablation 4 , and electrode placement in Deep Brain Stimulation (DBS) 5 . Computed tomography (CT) and ultrasound are commonly used for navigation for robot-assisted neurosurgery, due to their fast imaging capabilities.…”

Section: Introductionmentioning

confidence: 99%

A deep unrolled neural network for real-time MRI-guided brain intervention

He,

Zhu,

Chen

et al. 2023

Nat Commun

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Accurate navigation and targeting are critical for neurological interventions including biopsy and deep brain stimulation. Real-time image guidance further improves surgical planning and MRI is ideally suited for both pre- and intra-operative imaging. However, balancing spatial and temporal resolution is a major challenge for real-time interventional MRI (i-MRI). Here, we proposed a deep unrolled neural network, dubbed as LSFP-Net, for real-time i-MRI reconstruction. By integrating LSFP-Net and a custom-designed, MR-compatible interventional device into a 3 T MRI scanner, a real-time MRI-guided brain intervention system is proposed. The performance of the system was evaluated using phantom and cadaver studies. 2D/3D real-time i-MRI was achieved with temporal resolutions of 80/732.8 ms, latencies of 0.4/3.66 s including data communication, processing and reconstruction time, and in-plane spatial resolution of 1 × 1 mm2. The results demonstrated that the proposed method enables real-time monitoring of the remote-controlled brain intervention, and showed the potential to be readily integrated into diagnostic scanners for image-guided neurosurgery.

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Real-time MR-guided brain biopsy using 1.0-T open MRI scanner

Abstract: • Real-time MRI-guided brain biopsy using a 1.0-T open MRI scanner is safe, feasible and accurate. • No serious complications occurred in real-time MRI-guided brain biopsy. • Procedure duration is shortened and biopsy work flow is simplified.

Cited by 7 publications

References 28 publications

A novel three-dimensional template combined with MR-guided 125I brachytherapy for recurrent glioblastoma

A novel three-dimensional template combined with MR-guided 125I brachytherapy for recurrent glioblastoma

CT-MR Image Fusion for Post-Implant Dosimetry Analysis in Brain Tumor Seed Implantation- a Preliminary Study

A deep unrolled neural network for real-time MRI-guided brain intervention

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