Real-time monitoring of the mechanism of ibuprofen-cationic dextran crystanule formation using crystallization process informatics system (CryPRINS)

Abioye, Amos Olusegun; Chi-Tangyie, George; Simone, Elena; Nagy, Zoltán K.

doi:10.1016/j.ijpharm.2016.05.066

Cited by 26 publications

(20 citation statements)

References 32 publications

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“…Such methods would also be applicable to the synthesis process itself [37]. In this study, the probe-based (fiber)optical technologies Photon Density Wave (PDW) spectroscopy [38–41], Focused Beam Reflectance Measurement (FBRM) [42–45], Particle Vision Microscope (PVM) measurement [46–48], and turbidity measurement [49–51] are applied to study the LCST of aqueous PNIPAM suspensions and additionally its heating and cooling rate dependency.…”

Section: Introductionmentioning

confidence: 99%

Process analytical approaches for the coil-to-globule transition of poly(N-isopropylacrylamide) in a concentrated aqueous suspension

et al. 2016

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The coil-to-globule transition of poly(N-isopropylacrylamide) (PNIPAM) microgel particles suspended in water has been investigated in situ as a function of heating and cooling rate with four optical process analytical technologies (PAT), sensitive to structural changes of the polymer. Photon Density Wave (PDW) spectroscopy, Focused Beam Reflectance Measurements (FBRM), turbidity measurements, and Particle Vision Microscope (PVM) measurements are found to be powerful tools for the monitoring of the temperature-dependent transition of such thermo-responsive polymers. These in-line technologies allow for monitoring of either the reduced scattering coefficient and the absorption coefficient, the chord length distribution, the reflected intensities, or the relative backscatter index via in-process imaging, respectively. Varying heating and cooling rates result in rate-dependent lower critical solution temperatures (LCST), with different impact of cooling and heating. Particularly, the data obtained by PDW spectroscopy can be used to estimate the thermodynamic transition temperature of PNIPAM for infinitesimal heating or cooling rates. In addition, an inverse hysteresis and a reversible building of micrometer-sized agglomerates are observed for the PNIPAM transition process.Electronic supplementary materialThe online version of this article (doi:10.1007/s00216-016-0050-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Process analytical approaches for the coil-to-globule transition of poly(N-isopropylacrylamide) in a concentrated aqueous suspension

et al. 2016

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“…As described in the specification, the RBI of PVM is positively correlated with the concentration and/or the size of the particulate matter in the liquid. The RBI is used to characterize the number of crystals when PVM is used for dynamic monitoring of the crystallization process (Abioye et al, ). However, it is clear that the concentration of solids in the present work has not changed, and the variation of RBI can only be attributed to the size of the suspended solids.…”

Section: Resultsmentioning

confidence: 99%

“…Particle vision and measurement (PVM) is a widely used instrument in the field of crystallization in recent years. By monitoring the dynamic process visually, researchers have obtained many important data and learned more about the crystallization process (Abioye, Chi, Simone, & Nagy, ; Szilagyi & Nagy, ). As a real‐time microscope, PVM continuously records images of particles and particle structures as they naturally exist in the process.…”

Section: Introductionmentioning

confidence: 99%

Dynamic floc characteristics of flocculated coal slime water under different agent conditions using particle vision and measurement

Lin

Wang

Wang³

et al. 2019

Water Environment Research

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To determine the effect of different agents on the dynamic characteristics of floc structures, ferric chloride (FC) and anionic polyacrylamide (APAM) were dosed as coagulant and flocculant, respectively, to flocculate the coal slime water. Particle vision and measurement (PVM) was employed to monitor the flocculation process in situ. The results showed that the floc could grow to a size of approximately 1 mm only under conditions of 100 mg/L FC and 50 mg/L APAM. The coagulant dosage influenced either the aggregation of the slime particles or the conformation of the flocculant. If the coagulants were insufficient or excessive, the flocculant conformations were stretch chains and resembled unable to bridging the slime particles as shown in the captured images. The variation of the relative backscatter index (RBI) during the process indicated that the required residence time for flocculation was proportional to the ratio of particle size at the end of flocculation to that at the beginning of the process. It can be concluded that PVM is an effective instrument that can obtain useful dynamic information of the flocculation process by combining real-time images and the RBI. • Practitioner Points• The coagulant concentration affects the conformation of the flocculant. • The required retention time is depended on the max size that flocs can reach. • PVM is a powerful instrument for studying dynamic flocculation process in situ. • Key wordsanionic polyacrylamide; coal slime water; dynamic process; flocculation; particle vision and measurement

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“…Based on various experiments, DEX-coated nanoparticles showed more colloidal stability behaviour compared to those of coated with PEG chains [65] and also they show no nonspecific protein binding activity [66]. Interestingly, due to the ability of substitution of plentiful hydroxyl groups at the surface of DEX with various functional groups, DEX can be easily modified and conjugated to various molecules such as fluorescent dye, tetramethylrhodamine (TRITC-dextran) [67] and different drugs including ibuprofen [68] and platinum(IV) [69]. The particle size and its distribution are two major factors that control vital properties of final dextran nanogels such as water absorption capacity and its kinetics.…”

Section: Cationic Dextranmentioning

confidence: 99%

Significant role of cationic polymers in drug delivery systems

Farshbaf

Davaran

Zarebkohan

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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Cationic polymers are characterized as the macromolecules that possess positive charges, which can be either inherently in the polymer side chains and/or its backbone. Based on their origins, cationic polymers are divided in two category including natural and synthetic, in which the possessed positive charges are as result of primary, secondary or tertiary amine functional groups that could be protonated in particular situations. Cationic polymers have been employed commonly as drug delivery agents due to their superior encapsulation efficacy, enhanced bioavailability, low toxicity and improved release profile. In this paper, we focus on the most prominent examples of cationic polymers which have been revealed to be applicable in drug delivery systems and we also discuss their general synthesis and surface modification methods as well as their controlled release profile in drug delivery.

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Real-time monitoring of the mechanism of ibuprofen-cationic dextran crystanule formation using crystallization process informatics system (CryPRINS)

Cited by 26 publications

References 32 publications

Process analytical approaches for the coil-to-globule transition of poly(N-isopropylacrylamide) in a concentrated aqueous suspension

Process analytical approaches for the coil-to-globule transition of poly(N-isopropylacrylamide) in a concentrated aqueous suspension

Dynamic floc characteristics of flocculated coal slime water under different agent conditions using particle vision and measurement

Significant role of cationic polymers in drug delivery systems

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