2011
DOI: 10.1016/j.brainres.2011.03.008
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Real-time monitoring of spatial and temporal metabolic changes during focal cerebral ischemia in rats

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Cited by 4 publications
(1 citation statement)
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“…In rats, focal ischemia or ischemia/reperfusion has led to a decrease in ADP-stimulated and uncoupled respiration rates, with a marked fall in the respiratory control ratio [70], a transient decrease in complex IV activity [71] or a robust decline in complex IV activity [72], release of mitochondrial cytochrome c [73], potential activation of the mitochondrial permeability transition pore [74], a reduction in mitochondrial DNA content [75], depletion of mitochondrial glutathione [76], and a reversal of ATP synthetase activity [77]. Differences in mitochondrial function in the core and penumbral region of ischemia have also been reported [78]. It should however be noted that administration of 3-nitropropionic acid (3-NP), a miochondrial toxin, to rats prior to ischemia in order to induce tolerance, has resulted in decreased cerebral damage [79].…”
Section: Oxidative Stress and Mitochondrial Dysfunction In Neuronamentioning
confidence: 99%
“…In rats, focal ischemia or ischemia/reperfusion has led to a decrease in ADP-stimulated and uncoupled respiration rates, with a marked fall in the respiratory control ratio [70], a transient decrease in complex IV activity [71] or a robust decline in complex IV activity [72], release of mitochondrial cytochrome c [73], potential activation of the mitochondrial permeability transition pore [74], a reduction in mitochondrial DNA content [75], depletion of mitochondrial glutathione [76], and a reversal of ATP synthetase activity [77]. Differences in mitochondrial function in the core and penumbral region of ischemia have also been reported [78]. It should however be noted that administration of 3-nitropropionic acid (3-NP), a miochondrial toxin, to rats prior to ischemia in order to induce tolerance, has resulted in decreased cerebral damage [79].…”
Section: Oxidative Stress and Mitochondrial Dysfunction In Neuronamentioning
confidence: 99%