Real-time monitoring of nanomolar binding to a cyclodextrin monolayer immobilized on a Si/SiO2/novolac surface using white light reflectance spectroscopy: The case of triclosan

Maffeo, Davide; Velkov, Zhivko; Μισιακός, Κωνσταντίνος; Mergia, K.; Paulidou, Anastasia; Zavali, Maria; Mavridis, Irene M.; Yannakopoulou, Konstantina

doi:10.1016/j.jcis.2011.03.024

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…Triclosan is a kind of hydrophobic antibacterial agent having very low water solubility [34,35]. There are studies in the literature about the enhancement of triclosan solubility by forming IC with various kinds of CD and CD polymers [36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial electrospun nanofibers from triclosan/cyclodextrin inclusion complexes

Çelebioğlu

Umu

Tekinay

et al. 2014

Colloids and Surfaces B: Biointerfaces

123

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The electrospinning of nanofibers (NF) from cyclodextrin inclusion complexes (CD-IC) with an antibacterial agent (triclosan) was achieved without using any carrier polymeric matrix. Polymer-free triclosan/CD-IC NF were electrospun from highly concentrated (160% CD, w/w) aqueous triclosan/CD-IC suspension by using two types of chemically modified CD; hydroxypropyl-beta-cyclodextrin (HPβCD) and hydroxypropyl-gamma-cyclodextrin (HPγCD). The morphological characterization of the electrospun triclosan/CD-IC NF by SEM elucidated that the triclosan/HPβCD-IC NF and triclosan/HPγCD-IC NF were bead-free having average fiber diameter of 520 ± 250 nm and 1,100 ± 660 nm, respectively. The presence of triclosan and the formation of triclosan/CD-IC within the fiber structure were confirmed by (1)H-NMR, FTIR, XRD, DSC, and TGA studies. The initial 1:1 molar ratio of the triclosan:CD was kept for triclosan/HPβCD-IC NF after the electrospinning and whereas 0.7:1 molar ratio was observed for triclosan/HPγCD-IC NF and some uncomplexed triclosan was detected suggesting that the complexation efficiency of triclosan with HPγCD was lower than that of HPβCD. The antibacterial properties of triclosan/CD-IC NF were tested against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria. It was observed that triclosan/HPβCD-IC NF and triclosan/HPγCD-IC NF showed better antibacterial activity against both bacteria compared to uncomplexed pure triclosan.

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Section: Introductionmentioning

confidence: 99%

Antibacterial electrospun nanofibers from triclosan/cyclodextrin inclusion complexes

Çelebioğlu

Umu

Tekinay

et al. 2014

Colloids and Surfaces B: Biointerfaces

123

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“…The results show that the prepared glycoclusters can bind and partially protect ampicillin from degradation. 27,28 to monitor and quantify GNL interaction with 3 and WGA interaction with 5. The lectins were deposited on a surface in a fluidic cell (see Experimental) and formed a stable layer upon which solutions of 3 (or 5) were introduced.…”

Section: Resultsmentioning

confidence: 99%

“…The solutions were left to stand for 12 h at 4 o C before deposition on the interferometric WLRS setup, previously described in detail. 27,28 Briefly, four-inch silicon wafers with a thermally grown 300 nm thick SiO 2 film as the interferometric layer were used, upon which a thin novolac resin film (AZ-5214, AZ-EM materials) was deposited by spin coating and post-baked at a high temperature (180 o C, 1 h) to improve coating efficiency (50 to 100 Å). The coated wafer was placed in the incubation-fluidic cell and the protein solutions were channeled in at 60 µL/min and ∆λ max was monitored until a plateau was reached.…”

Section: Coupling Reactions Octakis-{6-deoxy-6-s-[6-(α-d-mannopyranosmentioning

confidence: 99%

Synthesis of cyclodextrin derivatives with monosaccharides and their binding with ampicillin and selected lectins

Lampropoulou¹,

Μισιακός²,

Paravatou³

et al. 2015

Arkivoc

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β-and γ-Cyclodextrins connected on their narrow side via 6 bond-linkers with monosaccharides (Man, GlcNAc) suitable for bacterial lectin recognition, along with reference mono-analogues were prepared. The resulting compounds: (a) posses a functional cavity forming inclusion complexes with a model guest molecule and with the antibiotic ampicillin; (b) inhibit by more than 30% the hydrolysis of ampicillin in the presence of the enzyme β-lactamase; (c) interact stronger with surface immobilized lectins than the reference mono-analogues. The present work suggests that combining the lectin recognition property of the compounds with their ability to encapsulate antibiotics could be used to target and kill bacteria.

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A Review on Triclosan: Persistance, Detection, and Remediation in Waste Streams

Gupta,

Kaur,

Talwar

et al. 2024

Water Air Soil Pollut

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Real-time monitoring of nanomolar binding to a cyclodextrin monolayer immobilized on a Si/SiO2/novolac surface using white light reflectance spectroscopy: The case of triclosan

Cited by 5 publications

References 30 publications

Antibacterial electrospun nanofibers from triclosan/cyclodextrin inclusion complexes

Antibacterial electrospun nanofibers from triclosan/cyclodextrin inclusion complexes

Synthesis of cyclodextrin derivatives with monosaccharides and their binding with ampicillin and selected lectins

A Review on Triclosan: Persistance, Detection, and Remediation in Waste Streams

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