Real-time monitoring of cyanobacterial harmful algal blooms by graphene field-effect transistor

Shin, Chan Jae; Seo, Sung Eun; Nam, Youngju; Kim, Kyung Ho; Kim, Lina; Kim, Jin-Yeong; Ryu, Eunsu; Hwang, Jong Yeon; Kim, Gyeong-Ji; Jung, Min-Woong; Lee, Seung Hwan; Kwon, Oh Seok

doi:10.1016/j.cej.2023.141419

Cited by 9 publications

(3 citation statements)

References 41 publications

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“…Meanwhile, reactive functionalized groups at the other end could react with the modified end of a single-stranded probe NA, allowing the probe to bind specifically to the graphene surface. Reported aromatic ring-functionalized molecules in G-FET NA detection included 1-pyrene-butyric acid N-hydroxysuccinimide ester (PBASE), [17] diaminonaphthalene, [18] bis(2-amino ethylene) perylene-3,4,9,10-tetra carboxyl diimide-diacid, [19] and bis(2-amino ethylene) perylene-3,4,9,10-tetra carboxyl diimidediamine. [20] Here, we used PBASE as an example to discuss the connection between aromatic ring-functionalized molecules and nonspecific signals of G-FET NA detection.…”

Section: Resultsmentioning

confidence: 99%

Aromatic Ring–Mediated Nonspecific Signaling Mechanism and Nafion‐Dominated Solution in Graphene Field‐Effect Transistor–Based Nucleic Acid Biosensors

Chen

Lyu

Sun

et al. 2023

Adv Funct Materials

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Graphene field‐effect transistors (G‐FETs) have attracted widespread attention in disease diagnosis, benefiting from these advantages of high sensitivity, label‐free, easy integration, and direct detection of nucleic acids (NAs) in liquid environments. However, the problem of nonspecific signals in G‐FETs is not fundamentally solved due to a lack of systematic theoretical research to support the development of effective solutions. Thus, researchers have to rely on speculative mechanisms to minimize nonspecific signals in experiments as much as possible. Herein, the nonspecific signal mechanism caused by eight types of π–π interaction paths mediated by aromatic rings is theoretically determined. Based on theoretical simulation results, the feasibility of blocking nonspecific signal paths through Nafion functionalization methods is experimentally verified. Experiments confirm that Nafion‐modified G‐FETs (NMG‐FETs) have excellent performance in avoiding nonspecific signals compared to traditional G‐FETs. Furthermore, the NMG‐FET achieves ultra‐sensitive detection of Down syndrome–related DNA down to 1 aM and severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) RNA down to 5 aM, and shows good specificity in base recognition. This study is expected to promote the theoretical advancement of the nonspecific signal mechanism in G‐FET NA detection and offer a practical strategy for improving signal purity and accuracy.

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Section: Resultsmentioning

confidence: 99%

Aromatic Ring–Mediated Nonspecific Signaling Mechanism and Nafion‐Dominated Solution in Graphene Field‐Effect Transistor–Based Nucleic Acid Biosensors

Chen

Lyu

Sun

et al. 2023

Adv Funct Materials

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“…To manufacture a FET biosensor, a wide range of nanomaterials has been applied, namely, oxides [44,45], carbon [47,60], conductive polymers [61,62], and composites [63,64] with diverse morphologies, such as nanoparticles [65], nanorods [66], 2D nanosheets [47], nanotubes [67,68], and nanowires [69] due to their high surface area to volume ratio, which is beneficial for immobilizing a large number of biological receptors, as illustrated in Figure 2. The existence of immobilized receptors in the device enables FET biosensors to recognize biomarkers, namely, prostate-specific antigens [70,71], antibiotics [72,73], bacteria [74,75], and viruses [76][77][78], with high sensitivity and selectivity.…”

Section: Nanomaterials Preparation For Fet Sensor Fabricationmentioning

confidence: 99%

Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor

Le,

Choi,

Cho

2023

Biosensors

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Alzheimer’s disease (AD) is closely related to neurodegeneration, leading to dementia and cognitive impairment, especially in people aged > 65 years old. The detection of biomarkers plays a pivotal role in the diagnosis and treatment of AD, particularly at the onset stage. Field-effect transistor (FET)-based sensors are emerging devices that have drawn considerable attention due to their crucial ability to recognize various biomarkers at ultra-low concentrations. Thus, FET is broadly manipulated for AD biomarker detection. In this review, an overview of typical FET features and their operational mechanisms is described in detail. In addition, a summary of AD biomarker detection and the applicability of FET biosensors in this research field are outlined and discussed. Furthermore, the trends and future prospects of FET devices in AD diagnostic applications are also discussed.

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“…Eutrophication occurs when an excess of nutrients (especially nitrogen and phosphorus) enters water supplies [4]. Overgrowth of algae and blue-green algae can increase the production of compounds such as 2-MIB and trans-1, 10-dimethyl-trans-9-dekalol (geosmin) [5]. These two chemical compounds cause the formation of T&O that can be perceived by humans at very low concentrations in the range of 4-10 ng/L [6].…”

mentioning

confidence: 99%

Bibliometric Overview of Research on Taste and Odor in Drinking Water during the 1980-2022

Ozgur

2023

Pol. J. Environ. Stud.

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Global warming causes rising temperatures and less rainfall in freshwater supplies, which increases the growth of algae and other organisms found in freshwater supplies [1]. Algae, especially blue-green algae, can produce 2-methylizoborneol (2-MIB), giving the water a bad taste and odor (T&O) [2]. Thus, the temperature rise in water supplies of global warming may increase the production of 2-MIB and other compounds [3]. Eutrophication occurs when an excess of nutrients (especially nitrogen and phosphorus) enters water supplies [4]. Overgrowth of algae and blue-green algae can increase the production of compounds such as 2-MIB and trans-1, 10-dimethyl-trans-9-dekalol (geosmin) [5]. These two chemical compounds cause the formation of T&O that can be perceived by humans at very low concentrations in the range of 4-10 ng/L [6]. These compounds can reach concentrations of 1000 ng/L in water sources during algal blooms [7]. In China and Japan, 2-MIB and geosmin are limited by regulations to the highest 10 ng/L in water resources, and in South

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Real-time monitoring of cyanobacterial harmful algal blooms by graphene field-effect transistor

Cited by 9 publications

References 41 publications

Aromatic Ring–Mediated Nonspecific Signaling Mechanism and Nafion‐Dominated Solution in Graphene Field‐Effect Transistor–Based Nucleic Acid Biosensors

Aromatic Ring–Mediated Nonspecific Signaling Mechanism and Nafion‐Dominated Solution in Graphene Field‐Effect Transistor–Based Nucleic Acid Biosensors

Alzheimer’s Disease Biomarker Detection Using Field Effect Transistor-Based Biosensor

Bibliometric Overview of Research on Taste and Odor in Drinking Water during the 1980-2022

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