Real-time monitoring of biofilm growth identifies andrographolide as a potent antifungal compound eradicating Candida biofilms

Eurobiofilms 2022: A translational perspective of biofilm-related persistent infections

“…Delaney et al, who presented the oral communication “Understanding biofilm heterogeneity and adaptation in Candida ”, propose an integrated transcriptomic and metabolomic method to investigate Candida albicans biofilm phenotype [ 17 ]. The original article by Žiemytė et al [ 18 ], by using real-time monitoring of biofilm growth, identified andrographolide, a natural compound isolated from the plant Andrographis paniculata , as a potent antifungal compound able to eradicate Candida biofilms. Cross-kingdom biofilms are also discussed, with the work by Díaz-Navarro et al [ 19 ], which assessed co-cultures of C. albicans and Escherichia coli in a large collection of vaginal samples.…”