Real-time measurements of ATP dynamics via ATeams in
Plasmodium falciparum
reveal drug-class-specific response patterns
Eric Springer,
Kim C. Heimsch,
Stefan Rahlfs
et al.
Abstract:Malaria tropica
, caused by the parasite
Plasmodium falciparum
(
P. falciparum
), remains one of the greatest public health burdens for humankind. Due to its pivotal role in parasite survival, the energy metabolism of
P. falciparum
is an interesting target for drug design. To this end, analysis of the central metabolite adenosine triphosphate (ATP) is of great interest. So far, only cell-disruptive or intensiometr… Show more
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