Real time measurement of cardiac pressure-volume relationships

Witschey, Walter R.; Contijoch, Francisco; Pilla, James J.; Dougherty, Lawrence; Song, Hee Kwon; Levack, Melissa M.; McGarvey, Jeremy R.; Kondo, Norihiro; Zsido, Gerald A; Gorman, Joseph H.; Gorman, Robert C.

doi:10.1186/1532-429x-14-s1-p227

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…The proposed method uses a smaller set of projections in a KWIC filter to reduce the problems associated with data sharing and subsequently removes the occurring aliasing artifacts using parallel imaging. A similar approach has already been used for cardiac imaging . An important parameter to be considered is the band‐width of the KWIC filter, which has to be adjusted for different applications, according to the dynamics of the data at hand and the parallel imaging capacity of the receiver array.…”

Section: Discussionmentioning

confidence: 99%

Reducing contrast contamination in radial turbo‐spin‐echo acquisitions by combining a narrow‐band KWIC filter with parallel imaging

Neumann

Breuer

Völker

et al. 2014

Magnetic Resonance in Med

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Purpose Cartesian turbo spin-echo (TSE) and radial TSE images are usually reconstructed by assembling data containing different contrast information into a single k-space. This approach results in mixed contrast contributions in the images, which may reduce their diagnostic value. The goal of this work is to improve the image contrast from radial TSE acquisitions by reducing the contribution of signals with undesired contrast information. Methods Radial TSE acquisitions allow the reconstruction of multiple images with different T2 contrasts using the k-space weighted image contrast (KWIC) filter. In this work, the image contrast is improved by reducing the band-width of the KWIC filter. Data for the reconstruction of a single image are selected from within a small temporal range around the desired echo time. The resulting data set is undersampled and therefore an iterative parallel imaging algorithm is applied to remove aliasing artifacts. Results Radial TSE images of the human brain reconstructed with the proposed method show an improved contrast when compared to Cartesian TSE images or radial TSE images with conventional KWIC reconstructions. Conclusion The proposed method provides multi-contrast images from radial TSE data with contrasts similar to multi spin-echo images. Contaminations from unwanted contrast weightings are strongly reduced.

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Section: Discussionmentioning

confidence: 99%

Reducing contrast contamination in radial turbo‐spin‐echo acquisitions by combining a narrow‐band KWIC filter with parallel imaging

Neumann

Breuer

Völker

et al. 2014

Magnetic Resonance in Med

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“…Loadindependent indices of ventricular function such as end-systolic pressure-volume and end-diastolic pressure-volume relationships are of particular interest, 28 and novel MRI techniques that serially quantify cardiac elastance and compliance in vivo will be used in future studies as an added metric of therapeutic efficacy. Because this study represents a paired comparison of ventricular function in the acute setting, we standardized device parameters across all treatment animals.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, miniaturization of the external gas exchange pump will allow for longterm assessment of ventricular size, strain/stress, and border zone function after device placement and activation. Loadindependent indices of ventricular function such as end-systolic pressure-volume and end-diastolic pressure-volume relationships are of particular interest, 28 and novel MRI techniques that serially quantify cardiac elastance and compliance in vivo will be used in future studies as an added metric of therapeutic efficacy.…”

Section: Discussionmentioning

confidence: 99%

Minimally Invasive Delivery of a Novel Direct Epicardial Assist Device in a Porcine Heart Failure Model

McGarvey

Shimaoka

Takebayashi

et al. 2014

Innovations�(Phila)

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Objective Despite advances in design, modern ventricular assist device placement involves median sternotomy and cardiopulmonary bypass and is associated with infectious/embolic complications. In this study, we examine the feasibility and function of a novel minimally invasive, non–blood-contacting epicardial assist device in a porcine ischemic cardiomyopathy model. Methods Feasibility was first tested in an ex vivo thoracoscopic trainer box with slaughterhouse hearts. Five male Yorkshire swine underwent selective ligation of the circumflex artery to create a posterolateral infarct Twelve weeks after infarct, all animals underwent left minithoracotomy. A custom inflatable bladder was positioned over the epicardial surface of the infarct and firmly secured to the surrounding border zone myocardium with polypropylene mesh and minimally invasive mesh tacks. An external gas pulsation system actively inflated and deflated the bladder in synchrony with the cardiac cycle. All animals then underwent cardiac magnetic resonance imaging to assess ventricular function. Results All subjects successfully underwent off-pump placement of the epicardial assist device via minithoracotomy. Ejection fraction significantly improved from 29.1% ± 4.8% to 39.6% ± 4.23% ( P < 0.001) when compared with pretreatment. End-systolic volume decreased (76.6 ± 13.3 mL vs 62.4 ± 12.0 mL, P < 0.001) and stroke volume increased (28.6 ± 3.4 mL vs 37.9 ± 3.1 mL, P < 0.05) when assisted. No change was noted in end-diastolic volume (105.1 ± 11.4 vs 100.3 ± 12.7). On postmortem examination, mesh fixation and device position were excellent in all cases. No adverse events were encountered. Conclusions Directed epicardial assistance improves ventricular function in a porcine ischemic cardiomyopathy model and may provide a safe alternative to currently available ventricular assist device therapies. Further, the technique used for device positioning and fixation suggests that an entirely thoracoscopic approach is possible.

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Minimally Invasive Delivery of a Novel Direct Epicardial Assist Device in a Porcine Heart Failure Model

et al. 2014

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Real time measurement of cardiac pressure-volume relationships

Cited by 3 publications

References 20 publications

Reducing contrast contamination in radial turbo‐spin‐echo acquisitions by combining a narrow‐band KWIC filter with parallel imaging

Reducing contrast contamination in radial turbo‐spin‐echo acquisitions by combining a narrow‐band KWIC filter with parallel imaging

Minimally Invasive Delivery of a Novel Direct Epicardial Assist Device in a Porcine Heart Failure Model

Minimally Invasive Delivery of a Novel Direct Epicardial Assist Device in a Porcine Heart Failure Model

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