Real time light induced fluorescence endoscopy (life) in the gastrointestinal (GI) tract

DuVall, G.A.; Saidi, Roxan; Kost, J; Scheider, DM; Lilge, Lothar; Cirocco, Maria; Hassaram, Shirley; Kandel, Gerald L.; Kortan, P; Haber, GB; Mang, Thomas; DaCosta, R; Wilson, Brian C.; Marcon, Norman E.

doi:10.1016/s0016-5107(97)80015-6

Cited by 10 publications

(7 citation statements)

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“…The available literature on this topic does not include any full publications; results have been presented in abstract form [15][16][17] and in review articles. 19 20 Haringsma and Tytgat 20 used AF for the detection of HGD and early cancer, with sensitivity and specificity rates of 87% each.…”

Section: Discussionmentioning

confidence: 99%

“…Only a few studies on MB staining have been conducted, [8][9][10][11][12][13][14] and the results of AF studies have been published only in abstract form or in reviews. [15][16][17][18][19] We therefore conducted a prospective study evaluating the sensitivity and specificity of MB staining and tissue AF measurement using high resolution video endoscopy (VE) with 4QB as the reference method in patients with established BO. The gold standard for the final diagnosis of normal BO or any form of dysplasia or cancer was histology of biopsies.…”

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confidence: 99%

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Biopsy surveillance is still necessary in patients with Barrett's oesophagus despite new endoscopic imaging techniques

Egger

2003

Gut

124

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Background and aims: Endoscopic surveillance including stepwise four quadrant biopsies (4QB) is still regarded as the standard approach in patients with Barrett's oesophagus (BO). Several methods such as dye staining with methylene blue (MB) and tissue autofluorescence (AF) have been advocated to reduce the number of biopsies. We assessed their sensitivity and specificity compared with the standard approach-that is, endoscopy with 4QB-in the surveillance of a mixed BO population. Patients and methods: Thirty five consecutive BO patients (mean age 64.9 years; 30 men, five women) were included in the study. AF endoscopy was followed by high resolution video endoscopy (VE) plus tissue staining with 0.5% MB. Biopsies were taken from any suspicious area found on any of the above tests, in addition to 4QB every 2 cm. The results were classified as either positive or negative for the various tests used. Histopathological results were used as the reference standard. Results: In the 35 study patients, a total of 345 biopsies showed low grade dysplasia (LGD) in 88 biopsies, high grade dysplasia (HGD) in 19 biopsies, and carcinoma in 12 biopsies. The sensitivity and specificity rates for AF and MB for the diagnosis of cancer or dysplasia versus BO mucosa without dysplasia were 21%/91% and 37%/91%, respectively. 4QB revealed five cancer/HGD areas and 76 LGD areas not detected by AF, MB, or VE. The additional yield of MB and AF over VE with 4QB concerned only one HGD area (in the vicinity of a cancer) and seven LGD areas. Conclusions: Due to their low sensitivity, AF and MB are not suitable techniques for reducing the high numbers of routine biopsies needed for finding additional foci of HGD or cancer. Careful endoscopic observation and stepwise four quadrant biopsy therefore still represent the gold standard for surveillance of Barrett's oesophagus.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Biopsy surveillance is still necessary in patients with Barrett's oesophagus despite new endoscopic imaging techniques

Egger

2003

Gut

124

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“…No comparative data on white-light endoscopy and no information on the nature and number of the lesions discovered with the fluorescence method were provided. One year later, the same group published data on autofluorescence imaging in the lower GI tract [49]. The autofluorescence images of 59 patients undergoing colonoscopy were evaluated by two endoscopists.…”

Section: Endoscopic Fluorescence Imaging In the Colonmentioning

confidence: 99%

“…No information on corresponding WL endoscopic data was provided. One year later, the same group published data on autofluorescence imaging in the upper GI tract [49]. In 43 patients undergoing gastroscopy, the autofluorescence images obtained and documented were evaluated by two endoscopists.…”

Section: Endoscopic Fluorescence Imaging In the Esophagusmentioning

confidence: 99%

Endoscopic fluorescence spectroscopic imaging in the gastrointestinal tract

Mayinger

2004

Gastrointestinal Endoscopy Clinics of North America

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“…[12][13][14][15][16][17][18][19][20][21][22][23][24] Images are also much easier to interpret for the examining doctor than results presented from selected positions. For some applications exogenous substances providing high fluorescence signals can be utilized.…”

Section: Introductionmentioning

confidence: 99%

Compact medical fluorosensor for minimally invasive tissue characterization

Klinteberg

Andreasson

Sandström

et al. 2005

Review of Scientific Instruments

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A compact fiber-optic point-measuring fluorosensor fully adapted to clinical studies is described. The system can use two excitation wavelengths, 337 and 405nm, obtained from a nitrogen laser directly, or after dye laser conversion, respectively. The image intensifier used in the spectrometer can be gated with a variable time delay, allowing also time-resolved spectra to be extracted, with a time resolution of about 4ns. Moreover, diffusely scattered white light can be spectrally recorded. The system is fully computer controlled enabling short recording times in clinical application, which are illustrated.

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Real time light induced fluorescence endoscopy (life) in the gastrointestinal (GI) tract

Cited by 10 publications

References 0 publications

Biopsy surveillance is still necessary in patients with Barrett's oesophagus despite new endoscopic imaging techniques

Biopsy surveillance is still necessary in patients with Barrett's oesophagus despite new endoscopic imaging techniques

Endoscopic fluorescence spectroscopic imaging in the gastrointestinal tract

Compact medical fluorosensor for minimally invasive tissue characterization

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