Real-time intraprocedural<sup>18</sup>F-FDG PET/CT-guided biopsy using automated robopsy arm (ARA) in the diagnostic evaluation of thoracic lesions with prior inconclusive biopsy results: initial experience from a tertiary health care centre

Radhakrishnan, Renjith Kalathoorakathu; Mittal, Bhagwant Rai; Gorla, Arun Kumar Reddy; Basher, Rajender Kumar; Sood, Ashwani; Bal, Amanjit; Kalra, Naveen; Khandelwal, Niranjan; Singh, Navneet; Behera, Digambar

doi:10.1259/bjr.20170258

Cited by 28 publications

(13 citation statements)

References 30 publications

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“…Background and recent advances. Intra-procedural 18 F-FDG PET/CT-guided biopsy using an automated robot arm has been reported [171,172]. Here, positioning of the biopsy needle and tissue sampling was fully automated using a registered robot arm based on lesion coordinates defined in the PET/CT images (see Figure 3(a-d)).…”

Section: Navigated Pet-or Spect-guided Biopsymentioning

confidence: 99%

“…Fixation of the patient with a vacuum-immobilization device helped preventing inaccuracies due to patient movement. Radhakrishnan et al reported this led to 100% successful diagnostic biopsies in 25 patients with intrathoracic lesions [172] and Kumar et al reported a diagnostic yield of 98.6% in 73 patients with bone lesions [171]. A down-side of such procedures is that they are time-consuming and can increase the radiation burden to the patient and medical staff [171].…”

Section: Navigated Pet-or Spect-guided Biopsymentioning

confidence: 99%

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Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Oosterom

Rietbergen

Welling

et al. 2019

Expert Review of Medical Devices

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Introduction: Radioguided surgery is an ever-evolving part of nuclear medicine. In fact, this nuclear medicine sub-discipline actively bridges non-invasive molecular imaging with surgical care. Next to relying on the availability of radio-and bimodal-tracers, the success of radioguided surgery is for a large part dependent on the imaging modalities and imaging concepts available for the surgical setting. With this review, we have aimed to provide a comprehensive update of the most recent advances in the field. Areas covered: We have made an attempt to cover all aspects of radioguided surgery: 1) the use of radioisotopes that emit γ, β + , and/or β − radiation, 2) hardware developments ranging from probes to 2D cameras and even the use of advanced 3D interventional imaging solutions, and 3) multiplexing solutions such as dual-isotope detection or combined radionuclear and optical detection. Expert opinion: Technical refinements in the field of radioguided surgery should continue to focus on supporting its implementation in the increasingly complex minimally invasive surgical setting, e.g. by accommodating robot-assisted laparoscopic surgery. In addition, hybrid concepts that integrate the use of radioisotopes with other image-guided surgery modalities such as fluorescence or ultrasound are likely to expand in the future.

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Section: Navigated Pet-or Spect-guided Biopsymentioning

confidence: 99%

Section: Navigated Pet-or Spect-guided Biopsymentioning

confidence: 99%

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Oosterom

Rietbergen

Welling

et al. 2019

Expert Review of Medical Devices

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“…The value of [ 18 F]FDG PET/CT-guided biopsy with an automated robotic biopsy arm has been evaluated by Radhakrishnan and collegues, where it has been reported as a feasible technique to accurately target metabolically active lesions. Furthermore, preliminary results from an ongoing trial in lymphoma patients indicates that [ 18 F]FDG PET/CT-guided biopsy is a potential tool for timely and accurate diagnosis [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Semi-Quantitative Characterization of Post-Transplant Lymphoproliferative Disorder Morphological Subtypes with [18F]FDG PET/CT

Jesus

Vergote

Noordzij

et al. 2021

JCM

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Background: Post-transplant lymphoproliferative disorder (PTLD) is a complication of organ transplantation classified according to the WHO as nondestructive, polymorphic, monomorphic, and classic Hodgkin Lymphoma subtypes. In this retrospective study, we investigated the potential of semi-quantitative 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) PET/computed tomography (CT)-based parameters to differentiate between the PTLD morphological subtypes. Methods: 96 patients with histopathologically confirmed PTLD and baseline [18F]FDG PET/CT between 2009 and 2019 were included. Extracted semi-quantitative measurements included: Maximum, peak, and mean standardized uptake value (SUVmax, SUVpeak, and SUVmean). Results: Median SUVs were highest for monomorphic PTLD followed by polymorphic and nondestructive subtypes. The median SUVpeak at the biopsy site was significantly higher in monomorphic PTLD (17.8, interquartile range (IQR):16) than in polymorphic subtypes (9.8, IQR:13.4) and nondestructive (4.1, IQR:6.1) (p = 0.04 and p ≤ 0.01, respectively). An SUVpeak ≥ 24.8 was always indicative of a monomorphic PTLD in our dataset. Nevertheless, there was a considerable overlap in SUV across the different morphologies. Conclusion: The median SUVpeak at the biopsy site was significantly higher in monomorphic PTLD than polymorphic and nondestructive subtypes. However, due to significant SUV overlap across the different subtypes, these values may only serve as an indication of PTLD morphology, and SUV-based parameters cannot replace histopathological classification.

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“…More recently, PETguided biopsy has emerged as a promising technique for transthoracic sampling. 14 Of note, the metabolic characterization provided by the PET-CT may allow targeting of viable tissue during sampling, thereby improving the diagnostic yield. Preliminary results revealed that for thoracic lesions having inconclusive results with previous invasive sampling, a diagnosis could be established in all the patients after PET-CT-guided biopsy.…”

Section: Diagnosis and Stagingmentioning

confidence: 99%

Lung Cancer in India

Singh

Agrawal

Jiwnani

et al. 2021

Journal of Thoracic Oncology

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Real-time intraprocedural¹⁸F-FDG PET/CT-guided biopsy using automated robopsy arm (ARA) in the diagnostic evaluation of thoracic lesions with prior inconclusive biopsy results: initial experience from a tertiary health care centre

Cited by 28 publications

References 30 publications

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Semi-Quantitative Characterization of Post-Transplant Lymphoproliferative Disorder Morphological Subtypes with [18F]FDG PET/CT

Lung Cancer in India

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Real-time intraprocedural18F-FDG PET/CT-guided biopsy using automated robopsy arm (ARA) in the diagnostic evaluation of thoracic lesions with prior inconclusive biopsy results: initial experience from a tertiary health care centre

Cited by 28 publications

References 30 publications

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Recent advances in nuclear and hybrid detection modalities for image-guided surgery

Semi-Quantitative Characterization of Post-Transplant Lymphoproliferative Disorder Morphological Subtypes with [18F]FDG PET/CT

Lung Cancer in India

Contact Info

Product

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Real-time intraprocedural¹⁸F-FDG PET/CT-guided biopsy using automated robopsy arm (ARA) in the diagnostic evaluation of thoracic lesions with prior inconclusive biopsy results: initial experience from a tertiary health care centre