Real-time Interobserver Agreement in Bowel Ultrasonography for Diagnostic Assessment in Patients With Crohn’s Disease: An International Multicenter Study

Calabrese, Emma; Kucharzik, Torsten; Maconi, Giovanni; Strobel, D; Wilson, Stephanie R.; Zorzi, Francesca; Novak, Kerri L.; Iacucci, Marietta; Watanabe, Mamoru; Lolli, Elisabetta; Chiaramonte, Carlo; Hanauer, Stephen B.; Panaccione, Remo; Pallone, Francesco; Ghosh, Subrata; Monteleone, Giovanni

doi:10.1093/ibd/izy091

Cited by 46 publications

(39 citation statements)

References 18 publications

(27 reference statements)

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“…Our results also agree with Calabrese et al [19] who reported that Mesenteric lymph nodes are another nonspecific sign of intestinal inflammation that may be seen during active disease and chronic intestinal inflammation.…”

Section: Discussionsupporting

confidence: 93%

The role of Trans-abdominal Ultrasound in Assessing Disease Activity and Severity in Ulcerative Colitis

Ragab

Heiza

Elmola

et al. 2020

International Journal of Medical Arts

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Background: Ulcerative colitis [UC] is an inflammatory disease of the colon with a relapsing-remitting course. Early diagnosis is crucial, and the presence of a screening test is of utmost importance. Bowel ultrasound could be used as a screening tool for UC. Aim of the work:To assess the diagnostic accuracy of bowel ultrasound in detecting disease activity and severity in adult patients with UC, compared with Ileocolonoscopy as the reference standard.Patients and methods: This prospective study included 42 adult patients with an established UC diagnosis for at least six months. All patients were subjected to full inquiry about their disease history, complete clinical examination, laboratory investigations, colonoscopy, and bowel ultrasound of the abdomen with Doppler mapping.Results: Colonoscopy revealed that 41% in remission and 59% in an activity. Thirty patients had left-sided, and 12 had an extensive UC. White blood cells, platelet count, erythrocyte sedimentation rate, and C-reactive protein significantly increased in patients with activity versus remission. But, hemoglobin concentrations significantly decreased. Colonic wall thickness significantly increased in patients with activity versus remission [5.17±0.74 vs. 2.57±0.24, respectively]. Hypoechogenic or lost colonic wall pattern, enlarged mesenteric lymph nodes and Doppler colonic wall-flow significantly increased in cases with disease activity versus remission [32.0%, 24.0% and 72.0% vs 0.0%, 0.0% and 0.0% respectively]. Conclusion:Transabdominal bowel ultrasound had a beneficial role in diagnosing ulcerative colitis. It could be used as a screening tool for rapid diagnosis or follow up of treatment.

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Section: Discussionsupporting

confidence: 93%

The role of Trans-abdominal Ultrasound in Assessing Disease Activity and Severity in Ulcerative Colitis

Ragab

Heiza

Elmola

et al. 2020

International Journal of Medical Arts

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“…A bowel wall thickness cutoff value of 3 mm in our study showed sensitivity (83.3%), specificity (50%), and accuracy (60%) in comparison to other studies, which showed sensitivities of 88% to 94%; however, specificity (93%-97%,) and diagnostic accuracy (94%) were higher in previous studies than in our study[ 9 , 15 ]. This finding can be explained by the lack of international agreement about standardized measurement parameters, which leads to interobserver variability between examiners[ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative study between bowel ultrasound and magnetic resonance enterography among Egyptian inflammatory bowel disease patients

Kamel

Sakr

Hamed

et al. 2020

WJG

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BACKGROUND Bowel ultrasound and magnetic resonance enterography (MRE) are decisive medical imaging modalities for diagnosing and locating bowel lesions with its extramural extent and complications. They assess the degree of activity, help clinicians to identify patients in need of surgery, and can be used for patient follow-up. AIM To compare the role of MRE and bowel ultrasound in diagnosis and follow-up of inflammatory bowel disease (IBD) patients in Egypt. METHODS The study was conducted on 40 patients with IBD. All patients were subjected to clinical assessment, laboratory investigations, bowel ultrasound, MRE, and colonoscopy up to the terminal ileum with biopsies for histopathological examination. RESULTS This study was conducted on 14 patients (35%) with ulcerative colitis and 26 patients (65%) with Crohn's disease; 34 (85%) of these patients had active disease. Bowel ultrasound detected different bowel lesions with the following accuracies: ileum (85%), large bowel (70%), fistula (95%), stricture and proximal dilatation (95%) and abscesses (100%). Also, it showed that statistically significance of bowel ultrasound in differentiation between remission and activity of IBD in comparison to MRE and colonoscopy. CONCLUSION In comparison to MRE, bowel ultrasound is a useful, non-invasive, and feasible bedside imaging tool for the detection of inflammation, detection of complications, and follow-up of IBD patients when performed by the attending physician.

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“…US is widely available and noninvasive; however, its accuracy depends on the examiner and is low in the proximal to terminal ileum region [99]. An international multicenter study reported that most US parameters used in CD showed moderate/substantial agreement [100]. Further studies will clarify the proper use of such non-ionizing radiation techniques.…”

Section: Ultrasonographymentioning

confidence: 99%

Objective evaluation for treat to target in Crohn’s disease

et al. 2020

Self Cite

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Background Crohn's disease (CD) is a chronic and destructive bowel disease; continued disease activity can lead to penetrating complications. With the recent advent of effective medications, the importance of using a treat-totarget approach to guide therapy is becoming important. Methods In this review, we reviewed the previous evidence for evaluating CD lesions. Results We describe ileocolonoscopy's role in assessing disease activity, as well as recent progress in modalities, such as balloon-assisted endoscopy, capsule endoscopy, magnetic resonance enterography, computed tomography enterography, and ultrasonography. Advances in modalities have changed CD assessment, with small-bowel involvement becoming more important. Conclusions Proper optimization is necessary in clinical practice.

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Real-time Interobserver Agreement in Bowel Ultrasonography for Diagnostic Assessment in Patients With Crohn’s Disease: An International Multicenter Study

Cited by 46 publications

References 18 publications

The role of Trans-abdominal Ultrasound in Assessing Disease Activity and Severity in Ulcerative Colitis

The role of Trans-abdominal Ultrasound in Assessing Disease Activity and Severity in Ulcerative Colitis

Comparative study between bowel ultrasound and magnetic resonance enterography among Egyptian inflammatory bowel disease patients

Objective evaluation for treat to target in Crohn’s disease

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