Real‐Time In Vivo Quantitative Monitoring of Drug Release by Dual‐Mode Magnetic Resonance and Upconverted Luminescence Imaging

Liu, Jianan; Bu, Jiwen; Bu, Wenbo; Zhang, Shengjian; Pan, Limin; Fan, Wenpei; Chen, Feng; Zhou, Liangpin; Peng, Weijun; Zhao, Kuaile; Du, Jiulin; Shi, Jianlin

doi:10.1002/ange.201400900

Cited by 34 publications

(17 citation statements)

References 30 publications

(17 reference statements)

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“…Besides mesoporous materials mentioned above, mesoporous silica nanospheres are becoming attractive and prospective in the fields of biology, drug delivery systems and cancer diagnosis and therapy [78][79][80]. Sn-containing mesoporous silica nanospheres (Sn-MSNSs) with uniform crater-like mesopores (Fig.…”

Section: Sn-containing Mesoporous Materials Catalystsmentioning

confidence: 99%

Sn-based catalysts for Baeyer-Villiger oxidations by using hydrogen peroxide as oxidant

Cui

Shi

2016

Sci. China Mater.

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Baeyer-Villiger (BV) oxidation is one of the most important transformation reactions in synthetic organic chemistry. Catalytic versions of the BV oxidation are particularly attractive in practical applications, because the catalytic transformation substantially simplifies reaction process while minimizing reactant consumption as well as waste production. Further benefits are expected from replacing peracids, the traditionally used oxidant, by low cost and environmentally friendly hydrogen peroxide (H2O2). This review will first introduce very briefly the features of BV oxidation reactions, and the corresponding oxidants traditionally used. Afterwards, the emphasis will be placed on the specific Sn-based catalysts, their performance comparison for the BV oxidation reaction by using H2O2 as oxidant, and the catalytic mechanisms of most Sn-based catalysts reported so far, including homogeneous Sn-based catalysts (such as Sn-based fluorous biphase system catalysts), heterogeneous Sn-based catalysts (such as Sn-based zeolite catalysts, Sn-based mesoporous composites, Sn-incorporated clay catalysts, Sn-based metal oxide composites and polymer supported Sn catalysts). Finally, the Sn-based catalysts for BV oxidation are outlooked for their potentials and perspectives in enhancing the performance and then accelerating the practical applications of BV oxidations by using H2O2. The developing direction of the Sn-based catalytic BV reaction is also illustrated.

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Section: Sn-containing Mesoporous Materials Catalystsmentioning

confidence: 99%

Sn-based catalysts for Baeyer-Villiger oxidations by using hydrogen peroxide as oxidant

Cui

Shi

2016

Sci. China Mater.

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“…tion [78,79], ligand-free synthesis [80], ligand attraction [81,82], electrostatic layer-by-layer assembly [83,84] and surface silanization [85,86] have been established (Fig. 3).…”

Section: Reviewsmentioning

confidence: 99%

“…In their pioneering work, PEI-capped Ca 1. 86 Mg 0.14 ZnSi 2 O 7 : Eu 2+ , Dy 3+ PLNPs and AFP antibody-conjugated Au NPs were selected as the energy donor and quencher, respectively, to construct an inhibition FRET pair. The FRET process was initiated between the energy donor and quencher in close proximity via electrostatic interaction, giving rise to the quenching of LLP of the donor centered at ~521 nm.…”

Section: Persistent Luminescent Bioassaymentioning

confidence: 99%

“…Surface silanization or silica coating commonly makes use of an inorganic amorphous silica shell to fabricate a hybrid core-shell nanocomposite. Such an amorphous silica shell is water-soluble, photostable and biocompatible, which allows easy surface carboxyl-functionalization (or amine-functionalization) for further bioconjugation [85,86]. Specifically, the mesoporous silica (mSiO 2 ) shell or yolk shell coating endows the NPs with excellent loading capabilities with diverse biological molecules or other functional moieties, making them ideal candidates for applications in multimodal bioimaging, targeted drug delivery and photodynamic therapy [89][90][91][92].…”

mentioning

confidence: 99%

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Inorganic lanthanide nanoprobes for background-free luminescent bioassays

Huang

Zheng

et al. 2015

Sci. China Mater.

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Luminescent bioassay techniques have been widely adopted in a variety of research and medical institutions. However, conventional luminescent bioassays utilizing traditional bioprobes like organic dyes and quantum dots often suffer from the interference of background noise from scattered lights and autofluorescence from biological matrices. To eliminate this disadvantage, the use of inorganic lanthanide (Ln 3+ )-doped nanoparticles (NPs) is an excellent option in view of their superior optical properties, such as the long-lived downshifting luminescence, near-infrared triggered anti-Stokes upconverting luminescence and excitation-free persistent luminescence. In this review, we summarize the latest advances in the development of inorganic Ln 3+ -doped NPs as sensitive luminescent bioprobes from their fundamental physicochemical properties to biodetection, including the chemical synthesis, surface functionalization, optical properties and their promising applications for background-free luminescent bioassays. Future efforts and prospects towards this rapidly growing field are also proposed. INTRODUCTIONSensitive and specific bioassay of trace amount of target analytes is essential for a variety of biomedical applications ranging from pharmaceutical preparation to disease diagnosis and therapy [1][2][3]. Among various bioassay methods, luminescent bioassay has received particular attention because of its high sensitivity and good specificity [4,5]. Conventional luminescent bioassay techniques such as enzyme-linked immunosorbent assay (ELISA), time-resolved (TR) fluoroimmunoassay (TRFIA), Förster resonance energy transfer (FRET) and TR-FRET assays have laid the foundation for many modern clinical applications [6][7][8][9][10][11]. However, these bioassays are impeded by the availability of traditional bioprobes like organic dyes, lanthanide (Ln 3+ ) chelates and quantum dots (QDs). The use of these bioprobes has a number of limitations. Organic dyes commonly possess poor photochemical stability and suffer from serious photobleaching [12]. The applicability of QDs is compromised by photoblinking and high toxic- ity of heavy metal elements like cadmium and selenium, especially for in vivo biosensing [13,14]. Moreover, both organic dyes and QDs may induce high background noise and considerable photodamage to the biological samples under ultraviolet (UV) excitation, which deteriorates their detection sensitivity for bioassays [15,16]. Although such background noise can be suppressed by the technique of TR photoluminescence (PL) through the use of the longlived luminescence of Ln 3+ -chelates, the poor photochemical stability, long-term toxicity and high cost of Ln 3+ -chelates remain a major issue [17]. These concerns fuel a crucial demand for the development of a new generation of luminescent bioprobes to circumvent the limitations of traditional ones.Recently, with the explosion of nanoscience and nanotechnology, there is a growing dedication towards the development of diverse luminescent nanoprobes for biodetection ...

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“…1−6 Enzymebased home glucometers best exemplify such technological advancements by helping millions of diabetic patients to monitor their glucose level and treat diabetes in the comfort of their home. 7−9 The ability to readily detect other small molecules at home, such as amino acids, lipids, sugars, or various therapeutic drugs, would open key avenues in diagnostics and treatment for various diseases and disorders, 10,11 including heart disease, 12 cancers, 13,14 and neurodegenerative diseases, 15 such as multiple sclerosis, 16 amyotrophic lateral sclerosis, 17,18 Alzheimer's, and Parkinson's. 11 However, the main challenges that have slowed down the commercialization of new quantitative home meters are that enzyme-based sensing mechanisms are hardly adaptable for the detection of most small molecules 19 while other assays based on electrocatalysis 20−24 or biorecognition 25−28 typically fail when performed directly in whole blood (e.g., sensor drift due to biofouling 27,28 ), or remain too cumbersome to be employed at home.…”

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confidence: 99%

Electrochemical DNA-Based Immunoassay That Employs Steric Hindrance To Detect Small Molecules Directly in Whole Blood

et al. 2017

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The development of a universal sensing mechanism for the rapid and quantitative detection of small molecules directly in whole blood would drastically impact global health by enabling disease diagnostics, monitoring, and treatment at home. We have previously shown that hybridization between a free DNA strand and its complementary surface-bound strand can be sterically hindered when the former is bound to large antibodies. Here, we exploit this effect to design a competitive antibody-based electrochemical assay, called CeSHHA, that enables the quantitative detection of small molecules directly in complex matrices, such as whole blood or soil. We discuss the importance of this inexpensive assay for point-of-care diagnosis and for treatment monitoring applications.

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Real‐Time In Vivo Quantitative Monitoring of Drug Release by Dual‐Mode Magnetic Resonance and Upconverted Luminescence Imaging

Cited by 34 publications

References 30 publications

Sn-based catalysts for Baeyer-Villiger oxidations by using hydrogen peroxide as oxidant

Sn-based catalysts for Baeyer-Villiger oxidations by using hydrogen peroxide as oxidant

Inorganic lanthanide nanoprobes for background-free luminescent bioassays

Electrochemical DNA-Based Immunoassay That Employs Steric Hindrance To Detect Small Molecules Directly in Whole Blood

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