Abstract:Renal ischemia‐reperfusion injury (IRI) is a complex disorder characterized by varying degrees of structural and functional losses. The degree of the insult depends on the severity of the condition and the kidney's ability to recover. IRI simultaneously contributes to the development of acute tubular injury and microvascular/endothelial injury. To further complicate matters, it is also believed that microvascular/endothelial injury leads to apoptotic signaling to, in turn, further reduce capillary density and … Show more
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