Real‐Time Imaging of Brain Tumor for Image‐Guided Surgery

Hu, Shuang; Kang, Homan; Baek, Yoonji; Fakhri, Georges El; Kuang, Anren; Choi, Hak

doi:10.1002/adhm.201800066

Cited by 75 publications

(56 citation statements)

References 122 publications

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“…By simply switching the detection camera in existing fluorescence navigation systems, we anticipate that the bright NIR‐II tail emission of the clinical NIR‐I dyes will boost the clinical translation of NIR‐II imaging techniques. A fluorescence navigation system with tunable detection bands spanning the NIR‐I to NIR‐II range could further support multiplexed fluorescent probe imaging for visualizing multicomponent complex disease processes simultaneously (Figure d) …”

Section: Nir‐ii Microscopy Imaging and Future Intraoperative Nir‐ii Imentioning

confidence: 99%

Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

et al. 2019

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Fluorescence bioimaging affords a vital tool for both researchers and surgeons to molecularly target a variety of biological tissues and processes. This review focuses on summarizing organic dyes emitting at a biological transparency window termed the near‐infrared‐II (NIR‐II) window, where minimal light interaction with the surrounding tissues allows photons to travel nearly unperturbed throughout the body. NIR‐II fluorescence imaging overcomes the penetration/contrast bottleneck of imaging in the visible region, making it a remarkable modality for early diagnosis of cancer and highly sensitive tumor surgery. Due to their convenient bioconjugation with peptides/antibodies, NIR‐II molecular dyes are desirable candidates for targeted cancer imaging, significantly overcoming the autofluorescence/scattering issues for deep tissue molecular imaging. To promote the clinical translation of NIR‐II bioimaging, advancements in the high‐performance small molecule–derived probes are critically important. Here, molecules with clinical potential for NIR‐II imaging are discussed, summarizing the synthesis and chemical structures of NIR‐II dyes, chemical and optical properties of NIR‐II dyes, bioconjugation and biological behavior of NIR‐II dyes, whole body imaging with NIR‐II dyes for cancer detection and surgery, as well as NIR‐II fluorescence microscopy imaging. A key perspective on the direction of NIR‐II molecular dyes for cancer imaging and surgery is also discussed.

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Section: Nir‐ii Microscopy Imaging and Future Intraoperative Nir‐ii Imentioning

confidence: 99%

Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

et al. 2019

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“…NIR light is featured with reduced scattering, minimal tissue absorption with high tissue penetration depth, and low tissue autofluorescence interference compared with visible light, and therefore suitable for bioimaging with high signal-to-background ratio and resolution of deep tissues. [1][2][3][4][5] In addition, it shows minimum genotoxicity. 6 These characteristics collectively favor the therapeutic use of NIR light in the clinic.…”

Section: Introductionmentioning

confidence: 99%

High-throughput single-cell live imaging of photobiomodulation with multispectral near-infrared lasers in cultured T cells

et al. 2020

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Significance: Photobiomodulation is a well-established therapeutic modality. However, the mechanism of action is poorly understood, due to lack of research in the causal relationship between the near-infrared (NIR) light irradiation and its specific biological effects, hindering broader applications of this technology. Aim: Since biological chromophores typically show several absorption peaks, we determined whether specific effects of photobiomodulation are induced with a combination of two wavelengths at a certain range of irradiance only, rather than a single wavelength of NIR light. Approach: In order to analyze a wide array of combinations of multispectral NIR light at various irradiances efficiently, we developed a new optical platform equipped with two distinct wavelengths of NIR lasers by high-throughput multiple dosing for single-cell live imaging. Two wavelengths of 1064 and 1270 nm were selected based on their photobiomodulatory effects reported in the literature. Results: A specific combination of wavelengths at low irradiances (250 to 400 mW∕cm 2 for 1064 nm and 55 to 65 mW∕cm 2 for 1270 nm) modulates mitochondrial retrograde signaling, including intracellular calcium and reactive oxygen species in T cells. The time-dependent density functional theory computation of binding of nitric oxide (NO) to cytochrome c oxidase indicates that the illumination with NIR light could result in the NO release, which might be involved in these changes. Conclusions: This optical platform is a powerful tool to study causal relationship between a specific parameter of NIR light and its biological effects. Such a platform is useful for a further mechanistic study on not only photobiomodulation but also other modalities in photomedicine.

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“…Several intraoperative imaging techniques have been developed for determining the resection margin in brain tumors; these include neuronavigation, MRI, ultrasound, Raman spectroscopy, and optical fluorescence imaging. Combined with discovery of contrast agents, both MRI and optical fluorescence imaging have improved resectability of brain tumors ( 15 ). Fluorescence-guided surgery uses preoperative oral 5-aminolevulinic acid (5-ALA) for intraoperative visualization of glioblastoma tissue and enables the neurosurgeon to differentiate tumor from normal brain for achieving a more extensive resection of the tumor as compared to that possible with use of conventional operating room light ( 16 ).…”

Section: Role Of Improvements In Diagnostic Technologiesmentioning

confidence: 99%

A Critical Overview of Targeted Therapies for Glioblastoma

2018

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Over the past century, treatment of malignant tumors of the brain has remained a challenge. Refinements in neurosurgical techniques, discovery of powerful chemotherapeutic agents, advances in radiotherapy, applications of biotechnology, and improvements in methods of targeted delivery have led to some extension of length of survival of glioblastoma patients. Refinements in surgery are mentioned because most of the patients with glioblastoma undergo surgery and many of the other innovative therapies are combined with surgery. However, cure of glioblastoma has remained elusive because it requires complete destruction of the tumor. Radical surgical ablation is not possible in the brain and even a small residual tumor leads to rapid recurrence that eventually kills the patient. Blood-brain barrier (BBB) comprising brain endothelial cells lining the cerebral microvasculature, limits delivery of drugs to the brain. Even though opening of the BBB in tumor core occurs locally, BBB limits systemic chemotherapy especially at the tumor periphery, where tumor cells invade normal brain structure comprising intact BBB. Comprehensive approaches are necessary to gain maximally from promising targeted therapies. Common methods used for critical evaluation of targeted therapies for glioblastoma include: (1) novel methods for targeted delivery of chemotherapy; (2) strategies for delivery through BBB and blood-tumor barriers; (3) innovations in radiotherapy for selective destruction of tumor; (4) techniques for local destruction of tumor; (5) tumor growth inhibitors; (6) immunotherapy; and (7) cell/gene therapies. Suggestions for improvements in glioblastoma therapy include: (1) controlled targeted delivery of anticancer therapy to glioblastoma through the BBB using nanoparticles and monoclonal antibodies; (2) direct introduction of genetically modified bacteria that selectively destroy cancer cells but spare the normal brain into the remaining tumor after resection; (3) use of better animal models for preclinical testing; and (4) personalized/precision medicine approaches to therapy in clinical trials and translation into practice of neurosurgery and neurooncology. Advances in these techniques suggest optimism for the future management of glioblastoma.

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Real‐Time Imaging of Brain Tumor for Image‐Guided Surgery

Cited by 75 publications

References 122 publications

Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery

High-throughput single-cell live imaging of photobiomodulation with multispectral near-infrared lasers in cultured T cells

A Critical Overview of Targeted Therapies for Glioblastoma

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