Real-time functional magnetic resonance imaging neurofeedback can reduce striatal cue-reactivity to alcohol stimuli

Kirsch, Peter; Gruber, Isabella; Ruf, Matthias; Kiefer, Falk

doi:10.1111/adb.12278

Cited by 86 publications

(72 citation statements)

References 43 publications

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“…Furthermore, the results may contribute to the implementation of non-invasive neurobiological treatment options, such as neuro-feedback training, which has already been successfully used in the treatment of ADHD (Arns, de Ridder, Strehl, Breteler, & Coenen, 2009; Duric, Assmus, Gundersen, & Elgen, 2012) and problematic alcohol consumption (Kirsch, Gruber, Ruf, Kiefer, & Kirsch, 2015). …”

Section: Resultsmentioning

confidence: 99%

Exploring the Neural Basis of Avatar Identification in Pathological Internet Gamers and of Self-Reflection in Pathological Social Network Users

Leménager¹,

Dieter²,

Hill³

et al. 2016

Journal of Behavioral Addictions

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Background and aimsInternet gaming addiction appears to be related to self-concept deficits and increased angular gyrus (AG)-related identification with one’s avatar. For increased social network use, a few existing studies suggest striatal-related positive social feedback as an underlying factor. However, whether an impaired self-concept and its reward-based compensation through the online presentation of an idealized version of the self are related to pathological social network use has not been investigated yet. We aimed to compare different stages of pathological Internet game and social network use to explore the neural basis of avatar and self-identification in addictive use.MethodsAbout 19 pathological Internet gamers, 19 pathological social network users, and 19 healthy controls underwent functional magnetic resonance imaging while completing a self-retrieval paradigm, asking participants to rate the degree to which various self-concept-related characteristics described their self, ideal, and avatar. Self-concept-related characteristics were also psychometrically assessed.ResultsPsychometric testing indicated that pathological Internet gamers exhibited higher self-concept deficits generally, whereas pathological social network users exhibit deficits in emotion regulation only. We observed left AG hyperactivations in Internet gamers during avatar reflection and a correlation with symptom severity. Striatal hypoactivations during self-reflection (vs. ideal reflection) were observed in social network users and were correlated with symptom severity.Discussion and conclusionInternet gaming addiction appears to be linked to increased identification with one’s avatar, evidenced by high left AG activations in pathological Internet gamers. Addiction to social networks seems to be characterized by emotion regulation deficits, reflected by reduced striatal activation during self-reflection compared to during ideal reflection.

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Section: Resultsmentioning

confidence: 99%

Exploring the Neural Basis of Avatar Identification in Pathological Internet Gamers and of Self-Reflection in Pathological Social Network Users

Leménager¹,

Dieter²,

Hill³

et al. 2016

Journal of Behavioral Addictions

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“…To date, several studies show that neurofeedback training causes behavioral effects that are specific to the functional role of the targeted cortical area (Weiskopf et al, 2004; Bray et al, 2007; Caria et al, 2007; Rota et al, 2009; Shibata et al, 2011; Scharnowski et al, 2012, 2015; Robineau et al, 2014; Koush et al, 2015; Scharnowski and Weiskopf, 2015). Even more importantly, real-time fMRI neurofeedback training has also been shown to have therapeutic effects in chronic pain patients (deCharms et al, 2005; Guan et al, 2015), Parkinson’s disease (Subramanian et al, 2011), tinnitus (Haller et al, 2010), depression (Linden et al, 2012; Young et al, 2014), obsessive-compulsive disorder (Scheinost et al, 2013, 2014), spider phobia (Zilverstand et al, 2015), and addiction (Li et al, 2013; Karch et al, 2015; Kirsch et al, 2015; Hartwell et al, 2016). Especially for clinical applications of neurofeedback it is crucial that the learning effects persist beyond the initial training period and that voluntary control transfers to situations without neurofeedback information.…”

Section: Discussionmentioning

confidence: 99%

Maintenance of Voluntary Self-regulation Learned through Real-Time fMRI Neurofeedback

Robineau¹,

Meskaldji

Koush

et al. 2017

Front. Hum. Neurosci.

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Neurofeedback based on real-time functional magnetic resonance imaging (fMRI) is an emerging technique that allows for learning voluntary control over brain activity. Such brain training has been shown to cause specific behavioral or cognitive enhancements, and even therapeutic effects in neurological and psychiatric patient populations. However, for clinical applications it is important to know if learned self-regulation can be maintained over longer periods of time and whether it transfers to situations without neurofeedback. Here, we present preliminary results from five healthy participants who successfully learned to control their visual cortex activity and who we re-scanned 6 and 14 months after the initial neurofeedback training to perform learned self-regulation. We found that participants achieved levels of self-regulation that were similar to those achieved at the end of the successful initial training, and this without further neurofeedback information. Our results demonstrate that learned self-regulation can be maintained over longer periods of time and causes lasting transfer effects. They thus support the notion that neurofeedback is a promising therapeutic approach whose effects can last far beyond the actual training period.

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“…We discuss six areas that have included studies of BD/HD: response inhibition, working memory, verbal learning and memory, decision making and reward processing, alcohol cue reactivity, and socio-cognitive/socio-emotional processing (Table 2). Further, in order to focus this section of the mini review on task-related functional magnetic resonance imaging (fMRI) studies, we excluded discussion of functional connectivity (Gorka et al, 2013; Weiland et al, 2014; Morris et al, 2016), acute alcohol administration (Filbey et al, 2008), machine learning (Squeglia et al, 2017), treatment (Feldstein Ewing et al, 2016), and neurofeedback (Kirsch et al, 2016) studies that included young BD/HD, as well as studies where binge drinking was examined, but was not the main variable of interest (Glaser et al, 2014). …”

Section: Functional Magnetic Resonance Imaging (Fmri)mentioning

confidence: 99%

The Burden of Binge and Heavy Drinking on the Brain: Effects on Adolescent and Young Adult Neural Structure and Function

2017

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Introduction: Adolescence and young adulthood are periods of continued biological and psychosocial maturation. Thus, there may be deleterious effects of consuming large quantities of alcohol on neural development and associated cognition during this time. The purpose of this mini review is to highlight neuroimaging research that has specifically examined the effects of binge and heavy drinking on adolescent and young adult brain structure and function.Methods: We review cross-sectional and longitudinal studies of young binge and heavy drinkers that have examined brain structure (e.g., gray and white matter volume, cortical thickness, white matter microstructure) and investigated brain response using functional magnetic resonance imaging (fMRI).Results: Binge and heavy-drinking adolescents and young adults have systematically thinner and lower volume in prefrontal cortex and cerebellar regions, and attenuated white matter development. They also show elevated brain activity in fronto-parietal regions during working memory, verbal learning, and inhibitory control tasks. In response to alcohol cues, relative to controls or light-drinking individuals, binge and heavy drinkers show increased neural response mainly in mesocorticolimbic regions, including the striatum, anterior cingulate cortex (ACC), hippocampus, and amygdala. Mixed findings are present in risky decision-making tasks, which could be due to large variation in task design and analysis.Conclusions: These findings suggest altered neural structure and activity in binge and heavy-drinking youth may be related to the neurotoxic effects of consuming alcohol in large quantities during a highly plastic neurodevelopmental period, which could result in neural reorganization, and increased risk for developing an alcohol use disorder (AUD).

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Real-time functional magnetic resonance imaging neurofeedback can reduce striatal cue-reactivity to alcohol stimuli

Cited by 86 publications

References 43 publications

Exploring the Neural Basis of Avatar Identification in Pathological Internet Gamers and of Self-Reflection in Pathological Social Network Users

Exploring the Neural Basis of Avatar Identification in Pathological Internet Gamers and of Self-Reflection in Pathological Social Network Users

Maintenance of Voluntary Self-regulation Learned through Real-Time fMRI Neurofeedback

The Burden of Binge and Heavy Drinking on the Brain: Effects on Adolescent and Young Adult Neural Structure and Function

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