Real-time evaluation of nitric oxide (NO) levels in cortical and hippocampal areas with a nanopore-based electrochemical NO sensor

Jo, Areum; Do, Hyunkyung; Jhon, Gil‐Ja; Suh, Minah; Lee, Young-Mi

doi:10.1016/j.neulet.2011.04.053

Cited by 12 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because nitric oxide is a highly lipophilic and diffusible gas, it permeates biological membranes, reaching distances far beyond where it was generated. 33 In light of this, the chronic elevation of nitric oxide is expected to affect the vasculature reserve function found in the GM throughout the brain, which is shown by our finding of a diffuse decrease in CVR. Our results favor the notion that, in MS, atrophy is more prominently seen in GM than in WM because GM has a higher vascular density; thus, the CVR compromise may be more pronounced in GM than in WM.…”

Section: Discussionmentioning

confidence: 66%

Impaired Cerebrovascular Reactivity in Multiple Sclerosis

et al. 2014

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 66%

Impaired Cerebrovascular Reactivity in Multiple Sclerosis

et al. 2014

View full text Add to dashboard Cite

“…Results confirmed that the levels of NO release were not uniformly distributed within the cortical and hippocampal areas of living brain. Figure 10 shows the penetration track of the electrode in the brain and a typical result of NO measurements from cortical and hippocampal areas 24. Finnerty et al.…”

Section: Application Of No Electrochemical Sensorsmentioning

confidence: 99%

“…Protection methods to achieve high selectivity by preventing the interference of charged species (including anionic ascorbic acid, uric acid, neutral acetaminophen and cationic dopamine) were summarized. NO electrochemical sensors for detecting NO level in single cell 17, multi‐cell 21, kidney 22, 23, brain 24–26, heart 27, liver 28, 29, human blood serum samples 30, and plant cells 31–33 were detailed. The trends for developing a novel NO sensor were outlooked in the last part.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Sensors for Nitric Oxide Detection in Biological Applications

Scafa

et al. 2014

Electroanalysis

View full text Add to dashboard Cite

Nitric oxide (NO) plays an important role in physiological processes and it has been confirmed some human diseases are related to its biological function. Electrochemical sensors provide an efficient way to explore the NO function in biological processes. This review details different kinds of electrochemical sensors used for NO concentration detection between 2008 and 2013 together with their application in biological samples. Four commonly used electrodes and different assisted analysis membranes used for contributions towards the development of the novel sensors were summarized. Electrochemical sensors employed to measure NO concentration in a single cell, cell culture, tissue homogenate, organ, in vivo, human being, as well as in plant were also detailed. The trends of developing novel NO sensors were outlooked in the last part.

show abstract

“…5 One hypothesis for this global deficit in MS is the presence of chronically elevated nitric oxide levels, 6 which is secondary to repetitive vascular inflammatory cascades. Nitric oxide is a highly lipophilic and diffusible gas, 7 which acts as a vasodilator. Its overproduction may cause vascular habituation leading to a decrease in vasodilatory capacity and thus hypoxia during enhanced neuronal activity.…”

Section: Introductionmentioning

confidence: 99%

Cerebral blood flow modulation insufficiency in brain networks in multiple sclerosis: A hypercapnia MRI study

Marshall

Chawla

et al. 2016

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Cerebrovascular reactivity measures vascular regulation of cerebral blood flow and is responsible for maintaining healthy neurovascular coupling. Multiple sclerosis exhibits progressive neurodegeneration and global cerebrovascular reactivity deficits. This study investigates varied degrees of cerebrovascular reactivity impairment in different brain networks, which may be an underlying cause for functional changes in the brain, affecting long-distance projection integrity and cognitive function; 28 multiple sclerosis and 28 control subjects underwent pseudocontinuous arterial spin labeling perfusion MRI to measure cerebral blood flow under normocapnia (room air) and hypercapnia (5% carbon dioxide gas mixture) breathing. Cerebrovascular reactivity, measured as normocapnic to hypercapnic cerebral blood flow percent increase normalized by end-tidal carbon dioxide change, was determined from seven functional networks (default mode, frontoparietal, somatomotor, visual, limbic, dorsal, and ventral attention networks). Group analysis showed significantly decreased cerebrovascular reactivity in patients compared to controls within the default mode, frontoparietal, somatomotor, and ventral attention networks after multiple comparison correction. Regression analysis showed a significant correlation of cerebrovascular reactivity with lesion load in the default mode and ventral attention networks and with gray matter atrophy in the default mode network. Functional networks in multiple sclerosis patients exhibit varied amounts of cerebrovascular reactivity deficits. Such blood flow regulation abnormalities may contribute to functional communication disruption in multiple sclerosis.

show abstract

Real-time evaluation of nitric oxide (NO) levels in cortical and hippocampal areas with a nanopore-based electrochemical NO sensor

Cited by 12 publications

References 17 publications

Impaired Cerebrovascular Reactivity in Multiple Sclerosis

Impaired Cerebrovascular Reactivity in Multiple Sclerosis

Electrochemical Sensors for Nitric Oxide Detection in Biological Applications

Cerebral blood flow modulation insufficiency in brain networks in multiple sclerosis: A hypercapnia MRI study

Contact Info

Product

Resources

About