Real time electroporation control for accurate and safe in vivo non-viral gene therapy

Cukjati, D.; Batiuškaitė, Danutė; André, Franck; Miklavčič, Damijan; Mir, Lluis M.

doi:10.1016/j.bioelechem.2006.11.001

Cited by 138 publications

(130 citation statements)

References 29 publications

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“…Our algorithm is a step towards effective treatment planning, not only in clinical ECT, but also in other electroporation based treatments, such as gene electrotransfer, transdermal drug delivery and irreversible tumor ablation. [16][17][18] …”

Section: Discussionmentioning

confidence: 99%

“…19 The values were chosen in accordance with previous measurements of tumor and tissue conductivity and models of subcutaneous tumor and skin electroporation. 13,16,20 The electric field distribution was calculated for three different electrode geometries: two different parallel needle electrode arrays (Figure 2a,b) and a hexagonal electrode array with two different electrode polarities (Figure 2c,d). These geometries and polarities were chosen because they are frequently used in ECT research and therapy.…”

Section: Tissue Properties and Model Geometrymentioning

confidence: 99%

“…Our optimization algorithm successfully found the best parameters in all cases and with some further improvement it could be a useful tool in clinical ECT treatment planning as well as in treatment planning of other electroporation based treatments. [16][17][18] Županič A et al / Optimization of electroporation in electrochemotherapy …”

Section: Introductionmentioning

confidence: 99%

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Optimization of electrode position and electric pulse amplitude in electrochemotherapy

Županič¹,

Čorović²,

Miklavčič³

2008

Radiology and Oncology

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Section: Discussionmentioning

confidence: 99%

Section: Tissue Properties and Model Geometrymentioning

confidence: 99%

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Optimization of electrode position and electric pulse amplitude in electrochemotherapy

Županič¹,

Čorović²,

Miklavčič³

2008

Radiology and Oncology

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“…Conductivity values of the different tissues are taken from the literature (Gabriel et al 1996;Haemmerich et al 2009), while the change of conductivity due to electroporation is set to a factor of 3.5 (Cukjati et al 2007). The magnitude of conductivity change has also recently been confirmed on ex vivo chicken liver using magnetic resonance electrical impendance tomographic imaging (Kranjc et al 2012).…”

Section: Electric Field Distribution Calculation and Optimizationmentioning

confidence: 99%

Planning of Electroporation-Based Treatments Using Web-Based Treatment-Planning Software

et al. 2013

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Electroporation-based treatment combining high-voltage electric pulses and poorly permanent cytotoxic drugs, i.e., electrochemotherapy (ECT), is currently used for treating superficial tumor nodules by following standard operating procedures. Besides ECT, another electroporation-based treatment, nonthermal irreversible electroporation (N-TIRE), is also efficient at ablating deepseated tumors. To perform ECT or N-TIRE of deep-seated tumors, following standard operating procedures is not sufficient and patient-specific treatment planning is required for successful treatment. Treatment planning is required because of the use of individual long-needle electrodes and the diverse shape, size and location of deepseated tumors. Many institutions that already perform ECT of superficial metastases could benefit from treatmentplanning software that would enable the preparation of patient-specific treatment plans. To this end, we have developed a Web-based treatment-planning software for planning electroporation-based treatments that does not require prior engineering knowledge from the user (e.g., the clinician). The software includes algorithms for automatic tissue segmentation and, after segmentation, generation of a 3D model of the tissue. The procedure allows the user to define how the electrodes will be inserted. Finally, electric field distribution is computed, the position of electrodes and the voltage to be applied are optimized using the 3D model and a downloadable treatment plan is made available to the user.

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“…Perspectivas apontam para o uso de correntes de alta voltagem e mínimo tempo de aplicação, seguidos de pulsos de baixa voltagem e longo tempo de duração (CUKJATI et al, 2007); (PAVSELJ e PREAT, 2005).…”

Section: As Correntes Elétricas Na Eletroporaçãounclassified

Transferência gênica in vivo por meio de eletroporação em músculo sóleo de ratos wistar.

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Real time electroporation control for accurate and safe in vivo non-viral gene therapy

Cited by 138 publications

References 29 publications

Optimization of electrode position and electric pulse amplitude in electrochemotherapy

Optimization of electrode position and electric pulse amplitude in electrochemotherapy

Planning of Electroporation-Based Treatments Using Web-Based Treatment-Planning Software

Transferência gênica in vivo por meio de eletroporação em músculo sóleo de ratos wistar.

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