Real-time Elastography for the Diagnosis of Prostate Cancer: Evaluation of Elastographic Moving Images

Miyagawa, Tomoaki; Tsutsumi, Masahiro; Matsumura, Takeshi; Kawazoe, Natsui; Ishikawa, Satoshi; Shimokama, Tatsuro; Miyanaga, Naoto; Akaza, Hideyuki

doi:10.1093/jjco/hyp026

Cited by 102 publications

(76 citation statements)

References 11 publications

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“…It has been used to examine several organs, such as the liver, thyroid, prostate, and pancreas. [23][24][25][26] It has been reported to be helpful in the differential diagnosis of metastasis in cervical and inguinal lymph nodes. [27][28][29] To our knowledge, there are no reports regarding the use of sonographic elastography in the evaluation of metastatic axillary lymph nodes in patients with breast cancer.…”

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confidence: 99%

Role of Sonographic Elastography in the Differential Diagnosis of Axillary Lymph Nodes in Breast Cancer

Choi

Kang

Kim

et al. 2011

Journal of Ultrasound in Medicine

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xillary lymph node status is the most important prognostic factor in breast cancer. 1 The presence of nodal metastases decreases 5-year survival by approximately 40% compared to node-negative patients. 2 Sentinel lymph node biopsy has replaced axillary lymph node dissection in patients with a low risk of axillary nodal metastases because of decreased morbidity. [3][4][5][6][7] Sentinel lymph node status is a representative indicator for the entire lymph node basin. However, false-negative results of sentinel lymph node biopsy have been found. 4,8,9 Noninvasive imaging techniques have been used to predict the preoperative axillary lymph node status. Sonography has higher diagnostic accuracy than mammography, computed tomography, magnetic resonance imaging, and positron emission tomographyJae Jeong Choi, MD, Bong Joo Kang, MD, PhD, Sung Hun Kim, MD, Ji Hye Lee, MD, Seung Hee Jeong, MPH, Hyun Woo Yim, MD, PhD, Byung Joo Song, MD, Sang Seol Jung, MD Received September 20, 2010, ORIGINAL RESEARCHObjectives-The purpose of this study was to evaluate the diagnostic utility of sonographic elastography in differentiating reactive and metastatic axillary lymph nodes in breast cancer.Methods-A total of 64 lymph nodes (reactive, n = 33; metastatic, n = 31) from 62 patients with breast cancer were examined by both B-mode sonography and elastography from April to July 2009. Two experienced radiologists retrospectively assessed B-mode sonograms by the sum of scores for 4 criteria: short diameter, shape, hilum, and cortical thickening. Elastographic images were given scores of 1 to 4 according to the percentage of high-elasticity areas in the lymph nodes. We compared the diagnostic performance of B-mode sonography, elastography, and combined examinations. We also calculated the strain ratio of the lymph node and subcutaneous fat tissue.Results-The elasticity score for malignant lymph nodes (mean, 3.1) was higher than the score for benign lymph nodes (mean, 2.2; P < .0001). With a cutoff between elasticity scores of 2 and 3, elastography showed 80.7% sensitivity, 66.7% specificity, and 73.4% accuracy. With a cutoff between B-mode sonographic scores of 1 and 2, B-mode sonography showed 74.2% sensitivity and 78.8% specificity. Combined B-mode and elastographic sonography showed higher sensitivity (87.1%) than B-mode sonography alone. With a strain ratio cutoff point of 2.3, sensitivity was 82.8%, and specificity was 56.3%.Conclusions-Sonographic elastography may increase the sensitivity of B-mode sonography in the detection of metastatic axillary lymph nodes.

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confidence: 99%

Role of Sonographic Elastography in the Differential Diagnosis of Axillary Lymph Nodes in Breast Cancer

Choi

Kang

Kim

et al. 2011

Journal of Ultrasound in Medicine

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“…Considering that echogenicity and the mechanical properties of body tissues are not correlated, a new tool to bridge the gap between ultrasound imaging and tissue structure and/or pathology, namely ultrasound elastography (UE), has been proposed and implemented 3 . UE is widely used in oncology to measure tissue elasticity, helping in the detection of malignant lesions and in the diagnosis and characterization of different types of cancer, such as breast, prostate, and thyroid 4,5,6 . It is considered a novel technique that can be used to assess tissue elasticity by detecting tissue deformities occurring after sequential movements of compression and relaxation determined by the operator through the ultrasound probe.…”

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Ultrasound Elastography Assessment of Skin Involvement in Systemic Sclerosis: Lights and Shadows

Iagnocco¹,

Kaloudi²,

Perella³

et al. 2010

J Rheumatol

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Objective. To assess skin elasticity in systemic sclerosis (SSc) by using a new imaging modality, ultrasound elastography (UE). Methods. Our study included 18 consecutive patients with SSc and 15 healthy controls. Modified Rodnan skin score, physical examination, and assessment of organ involvement were performed. UE was carried out on the middle forearm and on the fingers of the dominant arm. The echo signals recorded in real time during freehand operations of probe compression and relaxation produced images representing tissue elasticity, consisting of translucent colored bands superimposed on the B-mode ultrasonographic images. The color scale varied within a large band spectrum from red, indicative of soft and highly elastic tissue, to blue, which denoted hard and barely elastic tissue. Results. On the forearm of all patients, UE showed a homogeneous blue area corresponding to the dermis visualized in a B-mode ultrasonographic image; in controls, a blue pattern was never detected and a predominance of green with sporadic areas of pale blue was observed. At sequential evaluations, UE of fingers produced inconstant and changeable colored areas. Conclusion. The imaging pattern observed in the forearm of patients with SSc may represent the reduction of strain in the dermis clue to loss of elasticity. The variable pattern obtained by finger evaluation demonstrated that UE can assess skin involvement in SSc only in those areas where the dermis is known to be thicker and where the bone hyperreflection is minimal. Further studies are needed to confirm our results and determine the validity of this new imaging modality. (First Release June 15 2010; J Rheumatol 2010;37: 1688-91: doi:10.3899/jrheum.090974

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“…Phantom and in vivo results show that such a method has the potential to replace digital rectal examination (DRE). The usefulness of elastography was evaluated on 311 patients in Miyagawa et al (2009). They showed that the sensitivity of elastography and elastography + TRUS imaging in detecting cancer (confirmed by biopsy) is higher than that of DRE or TRUS only.…”

Section: Introductionmentioning

confidence: 99%

New Image-Based Techniques for Prostate Biopsy and Treatment

Moradi¹

2012

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE April 2012 REPORT TYPE Annual Summary DATES COVERED PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERUniversity of British Columbia Vancouver, CA V6T 1Z4 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTThis report details the research and training outcomes of a prostate cancer postdoctoral training award. The work resulted in technologies for segmentation, cancer detection, and brachytherapy seed detection that take advantage of ultrasound vibroelastography and ultrasound RF signals. In segmentation, we report a fully automatic algorithm that combines B-mode and elastography data within an active shape model approach. For cancer detection, we report the sensitivity of 75.5% for elastography in cancer detection. In brachytherapy seed detection and dosimetry, we showed that the use of raw RF ultrasound signals can result in partial detection of the seed clouds, sufficient for registration to C-arm fluoroscopy for the purpose of dosimetry. The results were published in form of five journal publications and six conference presentations in international journals and conferences. The PI attended nine conferences and meetings during the course of the award. SUBJECT TERMS IntroductionThis documents reports the accomplishments of the PI, Dr Mehdi Moradi, supported by the postdoctoral training Award W81XWH-10-1-0201, from April 1, 2010 to March 31, 2012. The progress on the specific task listed in the award will be listed. Since this is a training award, other achievements of the trainee during the award will be enumerated as well. The technology developed for vibroelastography was described in the annual report. We will focus on progress towards specific clinical outcomes and achievements of the trainee.The rationale of the proposal is that prostate tumors cannot be visualized in the ultrasound Bmode i...

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Real-time Elastography for the Diagnosis of Prostate Cancer: Evaluation of Elastographic Moving Images

Abstract: Elastography has a significantly higher sensitivity for the detection of prostate cancer than the conventionally used examinations including DRE and TRUS. It is a useful real-time diagnostic method because it is not invasive, and simultaneous evaluation is possible while performing TRUS.

Cited by 102 publications

References 11 publications

Role of Sonographic Elastography in the Differential Diagnosis of Axillary Lymph Nodes in Breast Cancer

Role of Sonographic Elastography in the Differential Diagnosis of Axillary Lymph Nodes in Breast Cancer

Ultrasound Elastography Assessment of Skin Involvement in Systemic Sclerosis: Lights and Shadows

New Image-Based Techniques for Prostate Biopsy and Treatment

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