Real-time elastography for the detection of fibrotic and inflammatory tissue in patients with stricturing Crohn’s disease

Serra, Carla; Rizzello, Fernando; Praticò, Chiara; Felicani, Cristina; Fiorini, E; Brugnera, Ramona; Mazzotta, Elena; Giunchi, Francesca; Fiorentino, Michelangelo; D’Errico, Antonietta; Morselli-Labate, Antonio Maria; Mastroroberto, Marianna; Campieri, Massimo; Poggioli, Gilberto; Gionchetti, Paolo

doi:10.1007/s40477-017-0265-2

Cited by 35 publications

(73 citation statements)

References 40 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1). Eventually, a total of 6 studies consisting of 4 full text articles [14,25,26,39] and 2 abstracts [41,42] met the eligibility criteria and were included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…▶ Table 1 shows the characteristics of the included studies. Only three studies reported the mean age of the participants and the proportion of men [25,26,39]: the mean age ranged from 35.5 years [25] to 46.1 years [26] and the proportion of men from 33.3 % [26] to 61.5 % [25]. One study included both humans and animals, but only the data regarding humans were considered [14].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…One study included both humans and animals, but only the data regarding humans were considered [14]. Two studies were carried out in Italy [25,39], two in the USA [14,41], one in Russia [42] and one in China [26]. All of the studies were carried out in a single center.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…All of the studies were carried out in a single center. Four studies [25,26,41,42] had a cohort design while two [14,39] were case-control studies.…”

Section: Study Characteristicsmentioning

confidence: 99%

See 3 more Smart Citations

Role of Ultrasound Elastography in the Detection of Fibrotic Bowel Strictures in Patients with Crohn’s Disease: Systematic Review and Meta-Analysis

et al. 2019

View full text Add to dashboard Cite

Purpose To perform a systematic review with meta-analysis to assess whether ultrasound elastography can have a diagnostic role in detecting fibrotic bowel strictures in patients with Crohn’s disease. Materials and Methods MEDLINE via the PubMed, Ovid Embase, Scopus and Cochrane Library databases, and abstracts of international conference proceedings were searched up to March 31, 2018. Studies were included if they assessed the performance of abdominal ultrasound elastography in detecting fibrotic bowel strictures in patients with Crohn’s disease using histology or the need for surgery after medical treatment as a reference standard. The quality of the studies was assessed using Quality Assessment of Diagnostic Accuracy Studies. Results 6 studies including a total of 217 patients with Crohn’s disease and 231 bowel segments, of which 76 were bowel segments with fibrotic stricture, were selected. Three studies used strain ratio and three studies used strain value as parameters of bowel stiffness. Both the pooled standardized mean strain ratio and the pooled standardized mean strain value were higher in bowel segments with fibrotic strictures than in those without fibrotic strictures with a standardized mean difference of 0.85 (95 % confidence level [CI]: 0 to 1.71; p = 0.05) and 1.0 (95 % CI: –0.11 to 2.10; p = 0.08), respectively. There was a high heterogeneity between studies. All studies were at “high risk” or “unclear risk” of bias. Conclusion Ultrasound elastography could be able to detect fibrotic bowel strictures in patients with Crohn’s disease. Well-designed high quality diagnostic studies with a large sample size are needed.

show abstract

“…1). Eventually, a total of 6 studies consisting of 4 full text articles [14,25,26,39] and 2 abstracts [41,42] met the eligibility criteria and were included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

“…All of the studies were carried out in a single center. Four studies [25,26,41,42] had a cohort design while two [14,39] were case-control studies.…”

Section: Study Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Role of Ultrasound Elastography in the Detection of Fibrotic Bowel Strictures in Patients with Crohn’s Disease: Systematic Review and Meta-Analysis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Even though there is little data available, the first results in this direction are promising, suggesting the ability of elastography to differentiate between inflammatory and fibrotic tissue, which is crucial for the management of these patients [95][96][97][98]. Fibrosis develops in time as a consequence of chronic inflammation and has a major influence on IBD morbidity, as it is associated with high rates of hospitalization and surgical interventions [99].…”

Section: Elastographymentioning

confidence: 99%

The importance of intestinal ultrasound and elastographic techniques in inflammatory bowel diseases

Marin

Tribus

Fierbinţeanu-Braticevici

2018

Med Ultrason

View full text Add to dashboard Cite

Inflammatory bowel diseases have an important impact upon the economic and social status due to their increasing incidence and prevalence, often affecting young people. At the moment, the therapeutic goal goes beyond the improvement of symptoms and laboratory parameters, being represented by endoscopic mucosal healing, changing the disease’s natural history. Even though endoscopy is the gold standard for the assessment of mucosal healing, it is an invasive maneuver and it lacks good repeatability. These patients require frequent evaluation; therefore, interest for noninvasive techniques has risen.As a consequence, the importance of intestinal ultrasound has increased lately and recent studies support its use to assess the degree of inflammation, to differentiate between remission and relapse, to monitor therapy response and guide treatment, to evaluate prognosis, and to diagnose complications. Another promising noninvasive imagistic technique is elastography which has gained interest because of its capacity to discriminate between inflammatory and fibrotic tissue, taking into account the different therapeutic options for the fibrotic strictures compared to inflammatory processes. This review summarizes the actual recommendations regarding the use of intestinal ultrasound and elastographic techniques for the diagnosis and monitoring of inflammatory bowel diseases.

show abstract

Feasibility of IntestinalMRElastography in Inflammatory Bowel Disease

Reiter

Loch

Kamphues

et al. 2021

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background While MR enterography allows detection of inflammatory bowel disease (IBD), the findings continue to be of limited use in guiding treatment—medication vs. surgery. Purpose To test the feasibility of MR elastography of the gut in healthy volunteers and IBD patients. Study Type Prospective pilot. Population Forty subjects (healthy volunteers: n = 20, 37 ± 14 years, 10 women; IBD patients: n = 20 (ulcerative colitis n = 9, Crohn's disease n = 11), 41 ± 15 years, 11 women). Field Strength/Sequence Multifrequency MR elastography using a single‐shot spin‐echo echo planar imaging sequence at 1.5 T with drive frequencies of 40, 50, 60, and 70 Hz. Assessment Maps of shear‐wave speed (SWS, in m/s) and loss angle (φ, in rad), representing stiffness and solid–fluid behavior, respectively, were generated using tomoelastography data processing. Histopathological analysis of surgical specimens was used as reference standard in patients. Statistical Tests Unpaired t‐test, one‐way analysis of variance followed by Tukey post hoc analysis, Pearson's correlation coefficient and area under the receiver operating characteristic curve (AUC) with 95%‐confidence interval (CI). Significance level of 5%. Results MR elastography was feasible in all 40 subjects (100% technical success rate). SWS and φ were significantly increased in IBD by 21% and 20% (IBD: 1.45 ± 0.14 m/s and 0.78 ± 0.12 rad; healthy volunteers: 1.20 ± 0.14 m/s and 0.65 ± 0.06 rad), whereas no significant differences were found between ulcerative colitis and Crohn's disease (P = 0.74 and 0.90, respectively). In a preliminary assessment, a high diagnostic accuracy in detecting IBD was suggested by an AUC of 0.90 (CI: 0.81–0.96) for SWS and 0.84 (CI: 0.71–0.95) for φ. Data Conclusion In this pilot study, our results demonstrated the feasibility of MR elastography of the gut and showed an excellent diagnostic performance in predicting IBD. Evidence Level 1 Technical Efficacy Stage 1

show abstract

Real-time elastography for the detection of fibrotic and inflammatory tissue in patients with stricturing Crohn’s disease

Cited by 35 publications

References 40 publications

Role of Ultrasound Elastography in the Detection of Fibrotic Bowel Strictures in Patients with Crohn’s Disease: Systematic Review and Meta-Analysis

Role of Ultrasound Elastography in the Detection of Fibrotic Bowel Strictures in Patients with Crohn’s Disease: Systematic Review and Meta-Analysis

The importance of intestinal ultrasound and elastographic techniques in inflammatory bowel diseases

Feasibility of IntestinalMRElastography in Inflammatory Bowel Disease

Contact Info

Product

Resources

About