Real time elastography for noninvasive diagnosis of liver fibrosis

Kanamoto, Mami; Shimada, Mitsuo; Ikegami, Toru; Uchiyama, Hideaki; Imura, Satoru; Morine, Yuji; Kanemura, Hirofumi; Arakawa, Yusuke; Nii, Akira

doi:10.1007/s00534-009-0075-9

Cited by 54 publications

(46 citation statements)

References 22 publications

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“…Subsequently, other authors have used strain ratio (SR) for assessing liver fibrosis, performing a ratio between the two areas of interest (ROI): one placed on the liver tissue and the other one in the intrahepatic veins [18][19][20], or in the intercostal muscles [21][22][23].…”

Section: The Liver Fibrosis Index (Lfi) Was First Published By Tatsummentioning

confidence: 99%

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Strain Elastography (SE) for liver fibrosis estimation – which elastic score to calculate?

et al. 2016

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Liver fibrosis scoring by liver biopsy has become a rarity in daily practice mainly because many non-invasive methods with similar accuracy have been developed. Among all ultrasound elastography imaging methods, Strain Elastography (SE) is the most widely available. Although SE is a qualitative and semi-quantitative method, there is reliable applicability for liver fibrosis estimation and multiple ways to transform SE into a quantitative method, in order to obtain a fibrosis score. The aim of this review is to briefly introduce all these methods and to offer support in choosing the best estimation method for liver fibrosis, with SE.

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Section: The Liver Fibrosis Index (Lfi) Was First Published By Tatsummentioning

confidence: 99%

“…Elastic ratio (ER1) was studied by Kanamoto et al [21], in a study of 41 patients with various pathologies. They performed a SR between hepatic parenchyma and intercostal muscles (fig 3).…”

Section: The Liver Fibrosis Index (Lfi) Was First Published By Tatsummentioning

confidence: 99%

Strain Elastography (SE) for liver fibrosis estimation – which elastic score to calculate?

et al. 2016

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“…If there is an increase in liver fibrosis is reduced strain (elasticity), so the color turns blue and strain measured the percent (%) value is reduced. [14,15] …”

Section: Real-time Elastographymentioning

confidence: 99%

Effect of levetiracetam on hepatic fibrosis in diabetic rats

Uyanıkgil

Akman

Çavuşoğlu³

et al. 2015

FNG & Bilim Tıp Dergisi

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Objectives: In our study we investigated the possible effects of levetiracetam (LEV) on hepatic fibrosis in streptozotocin (STZ) induced diabetic rats with histopathology, real-time elastography imaging technique. We also aimed to investigate the effects of LEV on oxidative stress markers. Materials and methods: Diabetes was induced by intraperitoneal (i.p.) single dose injection of STZ (60 mg/kg). Twenty-one rats were randomly divided into three groups; control group, STZ group treated with 1 mL/kg/day saline (STZ+SP), and STZ group treated with 600 mg/kg/day LEV was administrated by i.p. for four weeks. All rats underwent a real-time elastography (strain-elasticity %). The liver sections are examined by histopathologically (liver fibrosis score). In addition, malondialdehyde, total antioxidant capacity, and glutathione levels were measured in plasma. Results: Treatment with LEV significantly decreased liver fibrosis score and increased strain measurement % on the real-time elastography in diabetic rats. In addition, treatment with LEV significantly increased total antioxidant capacity, glutathione and malondialdehyde levels decreased in plasma of diabetic rats. Conclusion: Levetiracetam has potential as a treatment for diabetic liver injury and hepatic fibrosis and can be a good candidate among new treatment options. In addition, real-time elastography is reliable imaging non-invasive technique for detecting hepatic fibrosis.Keywords: Diabetes mellitus; levetiracetam; oxidative stress; real-time elastography.Diyabetik sıçanlarda karaciğer fibrozisi üzerine levetirasetam etkisi ÖZ Amaç: Bu çalışmada, streptozotocin (STZ) ile indüklenmiş diyabetik sıçanlardaki hepatik fibrozis üzerine levetirasetamın (LEV) pozitif etkilerinin histopatolojik ve gerçek zamanlı elastografik görüntüleme tekniği ile incelenmesi amaçlandı. Yine bu çalışmada LEV'nin oksidatif stres belirteçleri üzerine etkisi araştırıldı. Gereç ve yöntemler: Diyabetik model, tek doz intraperitoneal (i.p.) STZ (60 mg/kg) enjeksiyonu ile yapıldı. Yirmi bir sıçan rastgele olarak üç gruba ayrıldı; kontrol grubu, STZ uygulaması yapılıp 1 mL/kg/gün salin verilen grup (STZ+SP) ve STZ uygulanıp dört hafta boyunca 600 mg/kg/gün i.p LEV uygulanan grup. Tüm sıçanlar gerçek zamanlı elastografik yöntem ile incelendi (gerilme-elastikiyet yüzdesi). Karaciğerden alınan kesitler histopatolojik olarak değerlendirildi (karaciğer fibroz skoru). Bunlara ek olarak, plazmadan malondialdehit, total antioksidant kapasite ve glutatyon seviyeleri ölçüldü. Bulgular: Levetirasetam ile tedavi edilen diyabetik sıçanlarda karaciğer fibroz skorlamasında anlamlı bir azalma ve gerçek zamanlı elastografik gerilim-elastikiyet yüzdesinde artış saptandı. Bununla birlikte LEV tedavisinde diyabetik sıçanlarda total antioksidant kapasitesinin arttığı, glutatyon ve malondialdehitin plazma seviyelerinin azaldığı görüldü. Sonuç: Levetirasetam, diyabetik karaciğer hasarı ve karaciğer fibrozisi için yeni tedavi seçenekleri arasında iyi bir aday olabilir. Buna ek olarak gerçek zamanlı elasto...

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“…"Złotym standardem" w ocenie zaawansowania włóknienia wątroby jest biopsja. Elastografia wykonywana w trakcie badania ultrasonograficznego przez powłoki brzuszne stwarza szansę nieinwazyjnej oceny tego procesu [31,32].…”

Section: Elastografia Wątrobyunclassified

Endoscopic ultrasound elastography in digestive tract diseases

Motkowska¹,

Romatowski²,

Januszko³

et al. 2012

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S Sł ło ow wa a k kl lu uc cz zo ow we e: : ultrasonografia endoskopowa, elastografia, trzustka, węzły chłonne. K Ke ey y w wo or rd ds s: : endoscopic ultrasound, elastography, pancreas, lymph nodes. StreszczenieBadania obrazowe, takie jak ultrasonografia, tomografia komputerowa czy tomografia rezonansu magnetycznego, umożli-wiają wykrycie zmian chorobowych niedostępnych badaniem palpacyjnym. Wymienione techniki nie umożliwiają jednak oceny właściwości mechanicznych badanych tkanek, takich jak twardość czy sztywność. Założenie, że powyższe cechy tkanki zmienionej chorobowo różnią się od tkanki prawidło-wej oraz odkształca się ona inaczej pod wpływem fal ultradźwiękowych, jest podstawą elastografii ultrasonograficznej. Miniaturyzacja sprzętu oraz rozwój techniki ultrasonograficznej i endoskopowej umożliwiły zastosowanie w praktyce klinicznej połączenia obu tych metod. Dodatkowych informacji może dostarczać wykonywana w trakcie endoskopowego badania ultrasonograficznego elastografia. W niniejszej pracy przedstawiono przegląd piśmiennictwa dotyczącego doświad-czeń z wykorzystaniem endoskopowej elastografii ultrasonograficznej w diagnostyce schorzeń przewodu pokarmowego. Opublikowane doniesienia dotyczą badania trzustki, węzłów chłonnych położonych w sąsiedztwie przewodu pokarmowego (głównie w śródpiersiu) oraz zmian w okolicy zwieracza odbytu. Badanie elastograficzne wykonywane konwencjonalnie przez powłoki brzuszne jest wykorzystywane także w diagnostyce włóknienia wątroby. Abstract

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Real time elastography for noninvasive diagnosis of liver fibrosis

Abstract: Real-time elastography is a promising sonography-based noninvasive method for the preoperative assessment of liver fibrosis.

Cited by 54 publications

References 22 publications

Strain Elastography (SE) for liver fibrosis estimation – which elastic score to calculate?

Strain Elastography (SE) for liver fibrosis estimation – which elastic score to calculate?

Effect of levetiracetam on hepatic fibrosis in diabetic rats

Endoscopic ultrasound elastography in digestive tract diseases

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