Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers

David, Olivier; Sieno, Laura Di; Behera, Anurag; Ferocino, Edoardo; Contini, Davide; Condat, Laurent; Hervé, Lionel; Mars, Jérôme; Torricelli, Alessandro; Pifferi, Antonio; Mora, Alberto Dalla

doi:10.3390/s20102815

Cited by 7 publications

(6 citation statements)

References 53 publications

(69 reference statements)

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“…The miniaturization of a PET system is seriously limited as a result of the large volume and high working voltage of PSPMT. A silicon photomultiplier (SiPM), also referred to as a multi pixel photon counter (MPPC), according to the operation principle, as a new type of semiconductor device, is gradually replacing the PSPMT in a new generation of photodetectors in PET systems [ 13 , 14 , 15 , 16 , 17 ] based on the advantages of high quantum efficiency, high gain, fast time response, low operating voltage, compact structure, and immunity to magnetic fields [ 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Design and Evaluation of LYSO/SiPM LIGHTENING PET Detector with DTI Sampling Method

Deng

Chen

2020

Sensors

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Positron emission tomography (PET) has a wide range of applications in the treatment and prevention of major diseases owing to its high sensitivity and excellent resolution. However, there is still much room for optimization in the readout circuit and fast pulse sampling to further improve the performance of the PET scanner. In this work, a LIGHTENING® PET detector using a 13 × 13 lutetium-yttrium oxyorthosilicate (LYSO) crystal array read out by a 6 × 6 silicon photomultiplier (SiPM) array was developed. A novel sampling method, referred to as the dual time interval (DTI) method, is therefore proposed to realize digital acquisition of fast scintillation pulse. A semi-cut light guide was designed, which greatly improves the resolution of the edge region of the crystal array. The obtained flood histogram shown that all the 13 × 13 crystal pixels can be clearly discriminated. The optimum operating conditions for the detector were obtained by comparing the flood histogram quality under different experimental conditions. An average energy resolution (FWHM) of 14.3% and coincidence timing resolution (FWHM) of 972 ps were measured. The experimental results demonstrated that the LIGHTENING® PET detector achieves extremely high resolution which is suitable for the development of a high performance time-of-flight PET scanner.

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Section: Introductionmentioning

confidence: 99%

Design and Evaluation of LYSO/SiPM LIGHTENING PET Detector with DTI Sampling Method

Deng

Chen

2020

Sensors

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“…The customizable, low-light, fiber photometry system was applied in awake, freely moving mice to interrogate the behavioral correlates of the stress response. Another photonic-based imaging method -optical tomography -is also purposed using injectable fibers (silicon photomultipliers detectors) for dual-wavelength, real-time functional brain imaging (Orive-Miguel et al, 2020). The system allows to follow the brain activation variations over time through analysis of HbO and HbR concentration in the tissues (Figure 5D).…”

Section: Imaging Devices and Probesmentioning

confidence: 99%

“…These developments have resulted in a diverse range of implantable micro-imagers that are specifically designed for functional brain imaging with cell-type specificity, paving the way for enhanced experimental investigations in this area. Examples include the use of optical fiber bundles (Fedotov et al, 2017), light-sheet fluorescence or imaging devices applying photometry (Simone et al, 2018) and tomography (Orive-Miguel et al, 2020) to provide in vivo, highprecision measurements of calcium transients or oxy and deoxyhemoglobin tissue concentrations, respectively.…”

Section: Challenges Solutionsmentioning

confidence: 99%

Neurophotonics: a comprehensive review, current challenges and future trends

Barros,

Cunha

2024

Front. Neurosci.

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The human brain, with its vast network of billions of neurons and trillions of synapses (connections) between diverse cell types, remains one of the greatest mysteries in science and medicine. Despite extensive research, an understanding of the underlying mechanisms that drive normal behaviors and response to disease states is still limited. Advancement in the Neuroscience field and development of therapeutics for related pathologies requires innovative technologies that can provide a dynamic and systematic understanding of the interactions between neurons and neural circuits. In this work, we provide an up-to-date overview of the evolution of neurophotonic approaches in the last 10 years through a multi-source, literature analysis. From an initial corpus of 243 papers retrieved from Scopus, PubMed and WoS databases, we have followed the PRISMA approach to select 56 papers in the area. Following a full-text evaluation of these 56 scientific articles, six main areas of applied research were identified and discussed: (1) Advanced optogenetics, (2) Multimodal neural interfaces, (3) Innovative therapeutics, (4) Imaging devices and probes, (5) Remote operations, and (6) Microfluidic platforms. For each area, the main technologies selected are discussed according to the photonic principles applied, the neuroscience application evaluated and the more indicative results of efficiency and scientific potential. This detailed analysis is followed by an outlook of the main challenges tackled over the last 10 years in the Neurophotonics field, as well as the main technological advances regarding specificity, light delivery, multimodality, imaging, materials and system designs. We conclude with a discussion of considerable challenges for future innovation and translation in Neurophotonics, from light delivery within the brain to physical constraints and data management strategies.

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“…4(b) ]. 124 – 126 At more restricted depths, below 1 cm, spectroscopic optical coherence tomography (OCT) is also applicable, combining broadband illumination with spectrally-resolved interferometric detection. Although these methods have been widely explored in the clinical research setting, they are only just beginning to find routine application in the clinic for patient management.…”

Section: Depth-resolved Imagingmentioning

confidence: 99%

Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis

et al. 2022

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. Significance: Measurement and imaging of hemoglobin oxygenation are used extensively in the detection and diagnosis of disease; however, the applied instruments vary widely in their depth of imaging, spatiotemporal resolution, sensitivity, accuracy, complexity, physical size, and cost. The wide variation in available instrumentation can make it challenging for end users to select the appropriate tools for their application and to understand the relative limitations of different methods. Aim: We aim to provide a systematic overview of the field of hemoglobin imaging and sensing. Approach: We reviewed the sensing and imaging methods used to analyze hemoglobin oxygenation, including pulse oximetry, spectral reflectance imaging, diffuse optical imaging, spectroscopic optical coherence tomography, photoacoustic imaging, and diffuse correlation spectroscopy. Results: We compared and contrasted the ability of different methods to determine hemoglobin biomarkers such as oxygenation while considering factors that influence their practical application. Conclusions: We highlight key limitations in the current state-of-the-art and make suggestions for routes to advance the clinical use and interpretation of hemoglobin oxygenation information.

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Real-Time Dual-Wavelength Time-Resolved Diffuse Optical Tomography System for Functional Brain Imaging Based on Probe-Hosted Silicon Photomultipliers

Cited by 7 publications

References 53 publications

Design and Evaluation of LYSO/SiPM LIGHTENING PET Detector with DTI Sampling Method

Design and Evaluation of LYSO/SiPM LIGHTENING PET Detector with DTI Sampling Method

Neurophotonics: a comprehensive review, current challenges and future trends

Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis

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