Real-time dopamine efflux in the nucleus accumbens core during Pavlovian conditioning.

Sunsay, Ceyhun; Rebec, George V.

doi:10.1037/0735-7044.122.2.358

Cited by 31 publications

(33 citation statements)

References 44 publications

(70 reference statements)

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“…Consistent with our previous work (Sunsay & Rebec, 2008) as well as that of others (Day et al, 2007; Stuber et al, 2008), we observed DA signals during tone presentations, suggesting that phasic DA activity in the NAc serves as a neurochemical index of the associative strength of a CS. We also found that extinction reduced the amplitude of the DA signal.…”

Section: Discussionsupporting

confidence: 92%

“…Note the marked decrease in DA amplitude during extinction relative to the other phases. Peak height was measured as percent increase from the inflection point, which is at least two standard deviations above the mean of the preceding three successive points (Sunsay & Rebec, 2008). A repeated-measures ANOVA revealed a significant effect of phase (i.e., acquisition, extinction, reinstatement), F (2, 4) = 8.68, d = 0.9.…”

Section: Resultsmentioning

confidence: 99%

“…Data analysis focused on peak increases in oxidation current that were at least two standard deviations above the values recorded over the three immediately preceding scans. Peak increases >16% above baseline were routinely identified as DA in our previous study and we used the same criterion to monitor DA signals (Sunsay & Rebec, 2008). …”

Section: Methodsmentioning

confidence: 99%

“…This shift is argued to reflect anticipation of reward upon perception of the CS (Mirenowicz & Schultz, 1994; 1996). The subsequent use of fast-scan cyclic voltammetry (FSCV) confirmed that the shift in neuronal activity paralleled the release of DA (Day, Stuber, Wightman & Carelli, 2007; Stuber et al, 2008; Sunsay & Rebec, 2008). …”

mentioning

confidence: 86%

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Extinction and reinstatement of phasic dopamine signals in the nucleus accumbens core during Pavlovian conditioning.

Sunsay

Rebec

2014

Behavioral Neuroscience

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The prediction-error model of dopamine (DA) signaling has largely been confirmed with various appetitive Pavlovian conditioning procedures and has been supported in tests of Pavlovian extinction. Studies have repeatedly shown, however, that extinction does not erase the original memory of conditioning as the prediction-error model presumes, putting the model at odds with contemporary views that treat extinction as an episode of learning rather than unlearning of conditioning. Here, we combined fast-scan cyclic voltammetry (FSCV) with appetitive Pavlovian conditioning to assess DA release directly during extinction and reinstatement. DA was monitored in the nucleus accumbens core (NAc), which plays a key role in reward processing. Following at least 4 daily sessions of 16 tone-food pairings, FSCV was performed while rats received additional tone-food pairings followed by tone alone presentations (i.e., extinction). Acquisition memory was reinstated with non-contingent presentations of reward and then tested with cue presentation. Tone-food pairings produced transient (1–3 s) DA release in response to tone. During extinction, the amplitude of the DA response decreased significantly. Following presentation of two non-contingent food pellets, subsequent tone presentation reinstated the DA signal. Our results support the prediction-error model for appetitive Pavlovian extinction but not for reinstatement.

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Section: Discussionsupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 86%

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Extinction and reinstatement of phasic dopamine signals in the nucleus accumbens core during Pavlovian conditioning.

Sunsay

Rebec

2014

Behavioral Neuroscience

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“…Stabilization of new strategies may be enabled by D 1 receptormediated increases in cortico-striatal synaptic strengths (Floresco et al, 2001;Schotanus and Chergui, 2008) that could occur over the course of new learning during the setshift. Changes in phasic DA signaling may also contribute to the effects of D 1 receptor activation in facilitating setshifting, given that reward-related stimuli promote DA transients in the NAc (Day et al, 2007;Sunsay and Rebec, 2008). However, phasic DA activity in the ventral striatum is thought to act primarily on receptors located in or around DA synapses, whereas increases in tonic DA are believed to affect extrasynaptic receptors (Floresco, 2007).…”

Section: A Selective Role For Nac D 1 Receptors In Strategy Set-shiftingmentioning

confidence: 99%

Ventral Striatal Dopamine Modulation of Different Forms of Behavioral Flexibility

Haluk

Floresco

2009

Neuropsychopharmacol

183

174

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Different forms of behavioral flexibility are facilitated by interactions between separate regions of the prefrontal cortex and their striatal outputs. However, the contribution of ventral striatal dopamine (DA) to these functions is unclear. The present study assessed the involvement of DA receptors in the nucleus accumbens (NAc) core on either between-or within-strategy shifts using operant chamberbased tasks. Strategy set-shifting required rats initially to learn a visual-cue discrimination and, on the following day, shift to using an egocentric spatial response strategy to obtain reward. For reversal learning, rats were initially trained on a response discrimination and then required to select the opposite lever to receive food reward. Intra-NAc microinfusions of D 1 (SCH23390) but not D 2 (eticlopride) receptor antagonists impaired set-shifting, disrupting the maintenance of a new strategy. Conversely, supranormal activation of D 2 (quinpirole) but not D 1 (SKF81297) receptors also impaired set-shifting, inducing perseverative deficits. However, only infusions of the D 2 agonist impaired reversal learning, but did so without disrupting initial response learning. Thus, mesoaccumbens DA, acting on D 1 receptors, selectively facilitates complex forms of flexibility requiring shifts between different strategies, but does not appear to contribute to simpler forms of flexibility entailing shifts of specific stimulus-reward associations. In contrast, abnormal increases in D 2 receptor activity cause a more general impairment in behavioral flexibility. These findings suggest that deficits in these forms of executive functioning observed in disorders linked to dysfunction of the DA system may be attributable in part to aberrant increases or decreases in mesoaccumbens DA activity.

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Timing and Conditioning

Bonardi¹,

Cheung²,

Mondragón³

et al. 2016

The Wiley Handbook on the Cognitive Neuroscience of Learning

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Real-time dopamine efflux in the nucleus accumbens core during Pavlovian conditioning.

Cited by 31 publications

References 44 publications

Extinction and reinstatement of phasic dopamine signals in the nucleus accumbens core during Pavlovian conditioning.

Extinction and reinstatement of phasic dopamine signals in the nucleus accumbens core during Pavlovian conditioning.

Ventral Striatal Dopamine Modulation of Different Forms of Behavioral Flexibility

Timing and Conditioning

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