Real-time detection of lesion development in acute brain injury

Hartings, Jed A.; Dreier, Jens P.

doi:10.1177/0271678x16677764

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…In humans, these occur in the cortex as an electrocorticographic correlate of infarction or brain death and can reach negative amplitudes with magnitudes greater than 100 mV. 4,5,13,39,[56][57][58] The SD-initiated NUP may even be detected in the context of relatively small cortical infarcts. In Figure 7, we show for the first time an illustration of the electrocorticographic generation of the smallest infarct to date in which the SD-initiated NUP has ever been measured in humans.…”

Section: Discussionmentioning

confidence: 99%

Depth-profile of impairments in endothelin-1 – induced focal cortical ischemia

Vinokurova

Захаров

Chernova

et al. 2022

J Cereb Blood Flow Metab

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The development of ischemic lesions has primarily been studied in horizontal cortical space. However, how ischemic lesions develop through the cortical depth remains largely unknown. We explored this question using direct current coupled recordings at different cortical depths using linear arrays of iridium electrodes in the focal epipial endothelin-1 (ET1) ischemia model in the rat barrel cortex. ET1-induced impairments were characterized by a vertical gradient with (i) rapid suppression of the spontaneous activity in the superficial cortical layers at the onset of ischemia, (ii) compartmentalization of spreading depolarizations (SDs) to the deep layers during progression of ischemia, and (iii) deeper suppression of activity and larger histological lesion size in superficial cortical layers. The level of impairments correlated strongly with the rate of spontaneous activity suppression, the rate of SD onset after ET1 application, and the amplitude of giant negative ultraslow potentials (∼−70 mV), which developed during ET1 application and were similar to the tent-shaped ultraslow potentials observed during focal ischemia in the human cortex. Thus, in the epipial ET1 ischemia model, ischemic lesions develop progressively from the surface to the cortical depth, and early changes in electrical activity at the onset of ET1-induced ischemia reliably predict the severity of ischemic damage.

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