Neuromusculoskeletal (NMS) models enable non-invasive estimation of
clinically important internal biomechanics. A critical part of NMS
modelling involves estimating musculotendon kinematics, which comprise
musculotendon unit lengths, moment arms, and lines of action.
Musculotendon kinematics, which are partially dependent on joint
motions, define the non-linear mapping of muscle forces to joint moments
and contact forces. Currently, real-time computation of musculotendon
kinematics requires creation of a per-individual surrogate model. The
computational speed and accuracy of these surrogates degrade with
increasing number of coordinates. We developed a feed-forward neural
network that completely encodes musculotendon kinematics of a target
model across a wide anthropometric range, enabling accurate real-time
estimates of musculotendon kinematics without need for a priori
per-individual surrogate model. Compared to reference, the neural
network had median normalized errors ~0.1% for
musculotendon lengths, <0.4% for moment arms, and
<0.10° for line of action orientations. The neural network was
employed within an electromyography-informed NMS model to calculate hip
contact forces, demonstrating little difference (normalized root mean
square error 1.23±0.15%) compared to using reference musculotendon
kinematics. Finally, execution time was <0.04 ms per frame and
constant for increasing number of model coordinates. Our approach to
musculoskeletal kinematics may facilitate deployment of complex
real-time NMS modelling in computer vision or wearable sensors
applications to realize biomechanics monitoring, rehabilitation, and
disease management outside the research laboratory.