Real-Time Balloon Inflation Elastography for Prostate Cancer Detection and Initial Evaluation of Clinicopathologic Analysis

Tsutsumi, Masahiro; Miyagawa, Tomoaki; Matsumura, Takeshi; Endo, Tomoyoshi; Kandori, Shuya; Shimokama, Tatsuro; Ishikawa, Satoshi

doi:10.2214/ajr.09.3301

Cited by 56 publications

(43 citation statements)

References 23 publications

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“…Apart from liver imaging, it has many other clinical applications that have been reported in the literature, such as breast, thyroid, prostate and pancreas [33,34,35,36]. RTE image is constructed using tissue strains which are calculated from 2 consecutive frames.…”

Section: Introductionmentioning

confidence: 99%

Novel Image Analysis Method Using Ultrasound Elastography for Noninvasive Evaluation of Hepatic Fibrosis in Patients with Chronic Hepatitis C

Fujimoto¹,

Kato

Kudo

et al. 2013

Oncology

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It has been established that the long-term infection of chronic hepatitis C leads to the increased risk of hepatic fibrosis and hepatocellular carcinoma. Currently, histological diagnosis by invasive and painful liver biopsy is the gold standard for evaluating the hepatic fibrosis stage. Because of a side effect or patient inability to cope with the pain, it is difficult to assess the fibrosis stage frequently using liver biopsy. Recently, instead of liver biopsy, many articles have been published showing the usefulness of ultrasound elastography to evaluate the stage of hepatic fibrosis. We also reported the usefulness of real-time tissue elastography (RTE) for liver fibrosis staging in 2007. However, in our previous report, fibrosis classification was performed manually and the number of patients involved was also small. In the current study, the fibrosis staging is performed automatically using software by characterizing the elastography images. We have also increased the number of patients from 64 to 310. Thus, the aim of this study is to increase objectivity by using a newly developed automatic analysis method. We obtain the Liver Fibrosis Index (LFI), which is calculated from image features of RTE images, using multiple regression analysis performed on clinical data of 310 cases as the training data set. The correlation coefficient obtained between the LFI and the stage of hepatic fibrosis was r = 0.68, and significant differences exist between all stages of fibrosis (p < 0.001). Our new method seems promising since it has the ability to diagnose fibrosis even in the presence of inflammation.

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Section: Introductionmentioning

confidence: 99%

Novel Image Analysis Method Using Ultrasound Elastography for Noninvasive Evaluation of Hepatic Fibrosis in Patients with Chronic Hepatitis C

Fujimoto¹,

Kato

Kudo

et al. 2013

Oncology

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“…To address this challenge, Tsutsumi et al inflated a water balloon surrounding the transducer to compress the tissue, which reduced the operator dependence of the image quality. Using this method, the authors detected 71 % of histology confirmed PCa lesions [32]. [5] Overall, the multitude of studies performed using strain imaging has demonstrated great promise for guidance of targeted biopsies.…”

Section: Elastographic Imaging Methods In Prostate Strain Imagingmentioning

confidence: 99%

“…A skilled technician is needed to obtain adequately uniform compression, which can be challenging. Some recent studies have used inflatable balloons that surround the endorectal transducer and can be filled or emptied by the operator, thereby generating a more uniform stress on the prostate [27,31,32].…”

Section: Elastographic Imaging Methods In Prostate Strain Imagingmentioning

confidence: 99%

Prostate Elastography

Rosenzweig

Miller

Polascik

et al. 2014

Prostate Ultrasound

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“…An inflated balloon filled with water may be placed between the probe and the rectal wall to achieve more uniform compression. The difference in tissue displacement from one frame to another is used to generate an elastogram, which is a color map of local tissue strain (34). In a metaanalysis by Aboumarzouk et al (35), the sensitivity and specificity of SE were in the range of 71%-82% and 60%-95%, respectively, with radical prostatectomy specimens as the reference standard.…”

Section: Ultrasound Elastographymentioning

confidence: 99%

Utility of Ultrasound in the Diagnosis, Treatment, and Follow-up of Prostate Cancer: State of the Art

2016

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Prostate cancer screening currently consists of serum prostatespecific antigen and digital rectal examination, followed by transrectal ultrasound-guided biopsy for diagnostic confirmation. Although the current paradigm of prostate cancer screening has led to a decrease in advanced disease and cancer-related mortality, these techniques have limitations in terms of sensitivity and specificity, resulting in missed cancers that are clinically significant and the overdetection of clinically insignificant cancers. New imaging techniques and technologies are required to improve the detection of prostate cancer. This article summarizes the use of novel ultrasound techniques and technologies in the detection, biopsy, and treatment of prostate cancer.

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Real-Time Balloon Inflation Elastography for Prostate Cancer Detection and Initial Evaluation of Clinicopathologic Analysis

Cited by 56 publications

References 23 publications

Novel Image Analysis Method Using Ultrasound Elastography for Noninvasive Evaluation of Hepatic Fibrosis in Patients with Chronic Hepatitis C

Novel Image Analysis Method Using Ultrasound Elastography for Noninvasive Evaluation of Hepatic Fibrosis in Patients with Chronic Hepatitis C

Prostate Elastography

Utility of Ultrasound in the Diagnosis, Treatment, and Follow-up of Prostate Cancer: State of the Art

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