Real-time artificial intelligence for detection of upper gastrointestinal cancer by endoscopy: a multicentre, case-control, diagnostic study

Luo, Hongyu; Xu, Guoliang; Li, Chaofeng; He, Longjun; Luo, Linna; Wang, Zixian; Jing, Bingzhong; Deng, Yuhua; Jin, Ying; Yin, Li; Li, Bin; Tan, Wencheng; He, Caisheng; Seeruttun, Sharvesh Raj; Wu, Qiubao; Huang, Jun; Huang, De wang; Chen, Bin; Lin, S.; Chen, Qin ming; Yuan, Chu ming; Chen, Hai xin; Pu, Heng Ying; Zhou, Feng; He, Yun; Xu, Rui

doi:10.1016/s1470-2045(19)30637-0

Cited by 275 publications

(184 citation statements)

References 23 publications

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“…AI-facilitated diagnosis can alleviate doctors' workload and contribute to provision of high-quality medical care to patients in need. 7,8 It is well known that the diagnosis of disease depends on the intuition and experience of pathologists. Moreover, large workload can lead to pathologists' working inefficiency and increase the chance of mistakes being made.…”

Section: Roi Of Wsi Ementioning

confidence: 99%

Expert-level diagnosis of nasal polyps using deep learning on whole-slide imaging

Chen

Deng

et al. 2020

Journal of Allergy and Clinical Immunology

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Section: Roi Of Wsi Ementioning

confidence: 99%

Expert-level diagnosis of nasal polyps using deep learning on whole-slide imaging

Chen

Deng

et al. 2020

Journal of Allergy and Clinical Immunology

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“…[35][36] For example, the upper gastrointestinal cancer endoscopy AI intelligent diagnosis system (GRAIDS) not only helps diagnose upper gastrointestinal tumors, but also helps junior endoscopists reach the technical skill level of experienced endoscopists. 37 If the AI technology can be widely used in all levels of medical institutions, it will be of great significance to improve the level of early diagnosis and treatment of upper gastrointestinal cancer in China.…”

mentioning

confidence: 99%

Trends in incidence and mortality of esophageal cancer in Inner Mongolia, 2010–2015

Dong

Qiao

et al. 2020

Thoracic Cancer

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Background Esophageal cancer is among the leading cancer types in Inner Mongolia. This study aimed to investigate the incidence and mortality rates of esophageal cancer in 2015 and the trends in these rates in the 2010–2015 period in this region. Methods National Colorectal Cancer Roundtable (NCCR) screening methods and criteria were used to extract data from 10 cancer registries stratified by area (urban/rural), sex, and age group. The Chinese standard population in 2000 and Segi's world population were used to calculate age‐standardized rates. The annual percentage change (APC) in these rates was calculated using the Joinpoint Regression Program. Results In 2015, Inner Mongolia had 4324 new cases (4027 male vs. 297 female patients) and 3559 deaths (3300 male vs. 259 female patients) from esophageal cancer. The crude incidence, age‐standardized incidence by Chinese population, age‐standardized incidence by world population, and cumulative incidence were 13.45/100 000, 9.92/100 000, 10.18/100 000, and 1.30%, respectively. The corresponding figures for mortality were 11.32/100 000, 8.35/100 000, 8.53/100 000, and 1.04%. The incidence and mortality increased with age between 40 and 80 years. The rates in rural dwellers, especially men, showed negative APC (−13.25% vs. −11.08%; P < 0.05). Conclusions The incidence and mortality rates of esophageal cancer in Inner Mongolia increased between 2010 and 2015. The rates were higher in men in rural areas, middle‐aged and elderly individuals. Prevention and control programs focused on these groups, in addition to early diagnosis and treatment of esophageal cancer, are needed to reduce these rates. Key points Significant findings of the study: In Inner Mongolia, incidence and mortality rates of esophageal cancer were higher in urban areas than in rural areas and in men than in women between 2010 and 2015, and in middle‐aged and elderly than in younger people. What this study adds: Prevention and control programs, in addition to early diagnosis and treatment of esophageal cancer, should be tailored to specifically target men in rural areas and middle‐aged and elderly individuals in order to reduce the incidence and mortality rates of this pathology.

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“…Secondary attack rate was determined as the proportion of household members who were infected. The 95% confidence interval (CI) of the secondary attack rates was estimated using the Clopper-Pearson method [9]. The effect of baloxavir on transmission was estimated using univariate and multivariate logistic regression analyses, including other factors.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of baloxavir marboxil on household transmission of influenza infection

Umemura

Mutoh

Kawamura

et al. 2020

J Pharm Health Care Sci

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Background Baloxavir marboxil (baloxavir) is a new anti-influenza virus agent that is comparable to oseltamivir phosphate (oseltamivir). Since the efficacy of baloxavir in preventing household transmission of influenza is not well established, we compared the secondary household influenza virus transmission rates between patients on baloxavir vs oseltamivir. Methods Between October 2018 and March 2019, we enrolled index patients (diagnosed with influenza and treated with baloxavir or oseltamivir) and household members. The secondary attack rate of household members was compared between index patients treated with baloxavir vs oseltamivir. Risk factors of household transmission were determined using multivariate logistic analyses. Results In total, 169 index patients with influenza type A were enrolled. The median age was 27.0 (interquartile range; 11–57) years. The number of index patients treated with baloxavir and oseltamivir was 49 and 120, respectively. The secondary attack rate was 9.0% (95% confidence interval [CI]: 4.6–15.6) in the baloxavir group and 13.5% (95% CI: 9.8–17.9) in the oseltamivir group. In the multivariate analysis, independent risk factors were 0–6 years of age (odds ratio [OR] 2.78, 95% CI: 1.33–5.82, p < 0.01) and not being on baloxavir treatment. (OR: 0.63, 95% CI: 0.30–1.32, p = 0.22). Conclusion The household secondary attack rate of influenza was comparable in patients treated with baloxavir vs oseltamivir. Therefore, baloxavir can be used as an alternative therapy to oseltamivir in reducing household transmission of influenza. Trial registration Patients in this study were retrospectively registered. https://www.tosei.or.jp/clinical/pdf/2_influenza.pdf.

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Real-time artificial intelligence for detection of upper gastrointestinal cancer by endoscopy: a multicentre, case-control, diagnostic study

Cited by 275 publications

References 23 publications

Expert-level diagnosis of nasal polyps using deep learning on whole-slide imaging

Expert-level diagnosis of nasal polyps using deep learning on whole-slide imaging

Trends in incidence and mortality of esophageal cancer in Inner Mongolia, 2010–2015

Efficacy of baloxavir marboxil on household transmission of influenza infection

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