Using the effective field theory with correlations, we study mixed spin4 and spin-: Ising models with random bonds and crystal-field interactions on the honeycomb lattice. The nearestneighbour couplings J,, are taken as random variables with distribution P(J,j) = p6(Ji, -J)+(1 -p)6(Jiid), where J > 0 and (a( 5 1. In a certain range of negative values of a, the phase diagrams exhibit re-entrant behaviour. In detail, we investigate separately two kinds of disorder:bond dilution (a = 0) and random fJ interactions (a = -1). In both cases, the influence of the anisotropy on the phase diagrams shows some new outstanding features.