Readmission, healthcare consumption, and mortality in Clostridioides difficile infection hospitalizations: a nationwide cohort study

Sharma, Sachit; Weissman, Simcha; Walradt, Trent; Aziz, Muhammad; Vohra, Ishaan; Acharya, Ashu; Sotiriadis, John; Feuerstein, Joseph D.; Tabibian, James H.

doi:10.1007/s00384-021-04001-w

Cited by 5 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the cost incurred during admission was not analyzed in our study, the association between longer hospital LOS and higher cost for both the patient and hospital have been reported in prior studies. 8,9 The REM patients in our study were also more likely to have type 2 diabetes and CKD. Of interest, type 2 diabetes is a leading cause of CKD in the United States, and the prevalence of chronic diseases (including type 2 diabetes) is higher in REM groups than in n-REM individuals.…”

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

“…The potential relationship between medical insurance type or status, which is closely linked to socioeconomic standing, and CDI outcomes has been demonstrated previously. 9 Patients with Medicaid treated for CDI have a 16% higher readmission rate compared to those with Medicare. 9 Although we did not assess the direct impact of medical insurance on clinical outcomes, descriptively, REM patients were more likely to have Medicaid as their primary insurance, further demonstrating the probable influence of insurance type (or socioeconomic status) on deleterious health outcomes.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Examining the impact of racial disparities on Clostridioides difficile infection outcomes at a Southern California academic teaching hospital

Lee

Zhou

Ortiz-Gratacos

et al. 2023

Infect. Control Hosp. Epidemiol.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Examining the impact of racial disparities on Clostridioides difficile infection outcomes at a Southern California academic teaching hospital

Lee

Zhou

Ortiz-Gratacos

et al. 2023

Infect. Control Hosp. Epidemiol.

View full text Add to dashboard Cite

show abstract

“…Readmissions of patients with CDI are common [ 55 – 57 ], and the rate of recurrence is estimated to be approximately 15–35% of all CDI cases. Patients who experience recurrent episodes are at risk of second and subsequent recurrences [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Trends in the epidemiology of Clostridioides difficile infection in Germany

et al. 2023

View full text Add to dashboard Cite

Purposes Despite reports of a declining incidence over the last decade, Clostridioides difficile infection (CDI) is still considered the most important healthcare-associated causes of diarrhea worldwide. In Germany, several measures have been taken to observe, report, and influence this development. This report aims to analyze the development of hospital coding for CDI in Germany over the last decade and to use it to estimate the public health burden caused by CDI. Methods Reports from the Institute for Hospital Remuneration Systems, German Federal Statistical Office (DESTATIS), the Robert-Koch-Institute (RKI), Saxonian authorities and hospital quality reports during 2010–2021 were examined for CDI coding and assessed in a structured expert consultation. Analysis was performed using 2019 versions of Microsoft Excel® and Microsoft Access®. Results Peaks of 32,203 cases with a primary diagnosis (PD) of CDI and 78,648 cases with a secondary diagnosis (SD) of CDI were observed in 2015. The number of cases had decreased to 15,412 PD cases (− 52.1%) and 40,188 SD cases (− 48.9%) by 2021. These results were paralleled by a similar decline in notifiable severe cases. However, average duration of hospitalization of the cases remained constant during this period. Conclusions Hospital coding of CDI and notification to authorities has approximately halved from 2015 to 2021. Potential influential factors include hospital hygiene campaigns, implementation of antibiotic stewardship programs, social distancing due to the COVID-19 pandemic, and a decrease in more pathogenic subtypes of bacteria. Further research is necessary to validate the multiple possible drivers for this development.

show abstract

“…A further study conducted in 526 CDI admissions found a significantly higher mortality among the cirrhotic population than the noncirrhotic group (39.6% vs. 14.6%, p =0.001) [ 43 ]. An association was also established with the presence of cirrhosis and 30-day readmission for CDI [ 63 ]. Nonetheless, a study using data from the NIS during 2016-2017 found that cirrhosis was not associated with increased all-cause mortality (aOR 1.31, 95% CI 0.89–1.93) [ 42 ]; this may represent a change that has evolved in more recent years.…”

Section: Prognosismentioning

confidence: 99%

Clostridioides difficile Infection in Liver Cirrhosis: A Concise Review

Liu

Chen

2022

Canadian Journal of Gastroenterology and Hepatology

View full text Add to dashboard Cite

Clostridium difficile is a Gram-positive bacillus with fecal-oral transmission and is currently one of the most common nosocomial infections worldwide, which was renamed Clostridioides difficile in 2016. Clostridioides difficile infection (CDI) is a prevalent infection in cirrhosis and negatively affects prognosis. This study aimed to provide a concise review with clinical practice implications. The prevalence of CDI in cirrhotic patients increases, while the associated mortality decreases. Multiple groups of risk factors increase the likelihood of CDI in patients with cirrhosis, such as antibiotic use, the severity of cirrhosis, some comorbidities, and demographic aspects. Treatment in the general population is currently described in the latest guidelines. In patients with cirrhosis, rifaximin and lactulose have been shown to reduce CDI risk due to their modulatory effects on the intestinal flora, although conflicting results exist. Fecal microbiota transplantation (FMT) as a treatment for the second or subsequent CDI recurrences has demonstrated a good safety and efficacy in cirrhosis and CDI. Future validation in more prospective studies is needed. Screening of asymptomatic patients appears to be discouraged for the prevention currently, with strict hand hygiene and cleaning of the ward and medical equipment surfaces being the cornerstone of minimizing transmission.

show abstract

Readmission, healthcare consumption, and mortality in Clostridioides difficile infection hospitalizations: a nationwide cohort study

Cited by 5 publications

References 18 publications

Examining the impact of racial disparities on Clostridioides difficile infection outcomes at a Southern California academic teaching hospital

Examining the impact of racial disparities on Clostridioides difficile infection outcomes at a Southern California academic teaching hospital

Trends in the epidemiology of Clostridioides difficile infection in Germany

Clostridioides difficile Infection in Liver Cirrhosis: A Concise Review

Contact Info

Product

Resources

About