Readmission After ACS: Burden, Epidemiology, and Mitigation

Boulos, Peter K.; Messenger, John C.; Waldo, Stephen W.

doi:10.1007/s11886-022-01702-8

Cited by 4 publications

(2 citation statements)

References 92 publications

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“…Studies have shown that continuously improved and refined risk scoring systems help to better assist in early diagnosis and guide clinical care practices, [ 46 , 47 ] and epidemiologic studies have provided strong support for the development of more scientific prevention and treatment strategies. [ 48 , 49 ] Today, despite substantial progress in the diagnosis and treatment of ACS, cardiovascular disease remains the leading cause of death worldwide. [ 7 ] Among them, ACS complicating cardiogenic shock is a problem that requires special attention during the treatment of ACS patients.…”

Section: Discussionmentioning

confidence: 99%

The research progress and research trends in acute coronary syndrome nursing: A review of visual analysis based on the Web of Science database

Liu,

Li,

Mei

et al. 2024

Medicine

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Acute coronary syndrome (ACS) is one of the most common and severe forms of cardiovascular disease and has attracted worldwide attention with increased morbidity and mortality in recent years. There are few review studies in the field of its care in the form of bibliometric studies. We searched the Web of Science Core Collection database for articles and reviews in the area of ACS nursing for visual mapping analysis. Our objectives are to explore the hot topics and frontiers of research in the field of ACS nursing and to identify collaborative relationships between countries, institutions, and authors. This study will provide researchers with intuitive reference data for future in-depth studies of ACSs.

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Section: Discussionmentioning

confidence: 99%

The research progress and research trends in acute coronary syndrome nursing: A review of visual analysis based on the Web of Science database

Liu,

Li,

Mei

et al. 2024

Medicine

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“…This is likely due to infections, comorbidities, and medication-related adverse events such as bleeding. 30 Hence, post-discharge treatment plan is crucial to improve clinical outcomes, prevent hospitalization, and mortality among patients with ACS. 31 , 32 Among 12 quality strategies, case management, team-based care (involving allied health personnel such as nurses, pharmacists, and dietitians), and facilitated patient-provider communication (using either the manual/electronic tools, allied health personnel, or peer supporters) are most effective in preventing mortality and hospitalization due to any causes among patients with ACS.…”

Section: Discussionmentioning

confidence: 99%

Impact of multicomponent integrated care on mortality and hospitalization after acute coronary syndrome: a systematic review and meta-analysis

Hoo

Yang

Tan

et al. 2022

European Heart Journal - Quality of Care and Clinical Outcomes

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Aims Multicomponent integrated care is associated with sustained control of multiple cardiometabolic risk factors among patients with type 2 diabetes. There is a lack of data in patients with acute coronary syndrome (ACS). We aimed to examine its efficacy on mortality and hospitalization outcomes among patients with ACS in outpatient settings. Methods and results A literature search was conducted on PubMed, EMBASE, Ovid and Cochrane library databases for randomized controlled trials, published in English language between January 1980 and November 2020. Multicomponent integrated care defined as two or more quality improvement strategies targeting different domains (the healthcare system, healthcare providers and patients) for one month or more. The study outcomes were all-cause and cardiovascular-related mortality, hospitalization and emergency department visits. We pooled the risk ratio (RR) with 95% confidence interval (CI) for the association between multicomponent integrated care and study outcomes using the Mantel-Haenszel test. 74 trials (n = 93,278 patients with ACS) were eligible. The most common quality improvement strategies were team change (83.8%), patient education (62.2%) and facilitated patient-provider relay (54.1%). Compared with usual care, multicomponent integrated care was associated with reduced risks for all-cause mortality (RR 0.83, 95% CI 0.77-0.90; p<0.001; I2 = 0%), cardiovascular mortality (RR 0.81, 95% CI 0.73-0.89; p<0.001; I2 = 24%) and all-cause hospitalization (RR 0.88, 95% CI, 0.78-0.99; p = 0.040; I2 = 58%). The associations of multicomponent integrated care with cardiovascular-related hospitalization, emergency department visits and unplanned outpatient visits were not statistically significant. Conclusions In outpatient settings, multicomponent integrated care can reduce risks for mortality and hospitalization in patients with ACS.

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Early Use of PCSK9 Inhibitors in the Prognosis of Patients with Acute Coronary Syndrome by Protecting Vascular Endothelial Function

Xu,

Wang,

Wang

et al. 2024

Pharmacology

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Introduction: Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) has a protective effect on acute coronary syndrome (ACS). However, most studies have shown that this protective effect is based on a decrease in low-density lipoprotein cholesterol (LDL-C), while other mechanisms remain limited. This study aimed to determine whether PCSK9i can improve the prognosis of ACS patients by protecting endothelial function. Methods: A total of 113 ACS patients were enrolled and randomly assigned to PCSK9i group (PCSK9i combined with statins) and control group (statins only). Blood lipids and endothelial function indicators were measured and analyzed 6 weeks before and after treatment. The effect of PCSK9i on the expression and secretion of endothelial function indicators in vascular endothelial cells were studied by cell experiments. Results: After 6 weeks of treatment, endothelial function indicators such as NO, TM, ICAM-1, ET-1, and flow-mediated vasodilation (FMD) were significantly improved in PCSK9i group compared with control group. Only the changes of NO and vWF were associated with blood lipid levels, whereas the changes of other endothelial function indicators were not significantly associated with blood lipid levels. PCSK9i reduced the incidence of MACEs in patients with ACS compared to those in the control group. In cell experiments, PCSK9i treatment significantly ameliorated LPS induced endothelial injury in HUVECs. Conclusion: PCSK9i can protect vascular endothelial function partly independently of its lipid-lowering effect and ameliorate the prognosis of patients with ACS within 6 weeks. This mechanism may involve HSF1/HSPs related signaling pathways. Early use of PCSK9i in patients with ACS should be strongly considered in clinical practice.

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Readmission After ACS: Burden, Epidemiology, and Mitigation

Cited by 4 publications

References 92 publications

The research progress and research trends in acute coronary syndrome nursing: A review of visual analysis based on the Web of Science database

The research progress and research trends in acute coronary syndrome nursing: A review of visual analysis based on the Web of Science database

Impact of multicomponent integrated care on mortality and hospitalization after acute coronary syndrome: a systematic review and meta-analysis

Early Use of PCSK9 Inhibitors in the Prognosis of Patients with Acute Coronary Syndrome by Protecting Vascular Endothelial Function

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