Reading and Writing the Ubiquitin Code Using Genetic Code Expansion
Rishi S. Patel,
Nipuni M. Pannala,
Chittaranjan Das
Abstract:Deciphering ubiquitin proteoform signaling and its role in disease has been a long‐standing challenge in the field. The effects of ubiquitin modifications, its relation to ubiquitin‐related machineries, and its signaling output has been particularly limited by its reconstitution and means of characterization. Advances in genetic code expansion have contributed towards addressing these challenges by precision incorporation of unnatural amino acids through site selective codon suppression. This review discusses … Show more
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