In representative groups of patients with coronary heart disease (CHD) who underwent myocardial revascularization (CABG) on the background of postcovid syndrome (PKS), the features of the clinical-functional, metabolic and hemostatic state were studied. The effectiveness of the applied new medical rehabilitation programs has been evaluated, taking into account the severity of the mutual burden syndrome according to clinical, functional, laboratory and sociological indicators. Three new programs have been developed and scientifically substantiated for operated patients with coronary heart disease with mutual burden syndrome at the sanatorium-resort stage, complementing the standard treatment with the complex use of normobaric hypoxytherapy (GOT), hyperbaric oxygenation (HBO), halotherapy (GT) and ozone therapy (OT). The highest effectiveness of rehabilitation programs has been proven, including a combination of these therapeutic factors in patients with severe functional classes according to NYHA and the degree of severity of the mutual burden syndrome on the CIRS-G scale.