Readiness of high-risk populations in the HIV Network for Prevention Trials to participate in HIV vaccine efficacy trials in the United States

Koblin, Beryl A.; Heagerty, Patrick J.; Sheon, Amy R.; Buchbinder, Susan; Celum, Connie; Douglas, John M.; Gross, Michael L.; Marmor, Michael; Mayer, Kenneth H.; Metzger, David S.; Seage, George R.

doi:10.1097/00002030-199807000-00015

Cited by 126 publications

(116 citation statements)

References 9 publications

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“…This study finding is consistent with findings from other hypothetical vaccine preparedness studies (Koblin et al, 1998;Nyamathi et al, 2004;O'Connell et al, 2002;Strathdee et al, 2000). In particular, questions were raised about the stigma and discrimination due to post-vaccination seropositivity, as well as issues of confidentiality.…”

supporting

confidence: 93%

Perceptions of a Community Sample about Participation in Future HIV Vaccine Trials in South India

et al. 2006

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Focus group discussions were conducted to assess factors that might impact participation of subgroups in Chennai for future HIV vaccine trials. The participants were 112 men and women representing the following: (1) transport workers; (2) clients who attended a sexually transmitted disease clinic; (3) injection drug users; (4) men having sex with men; (5) women in sex work; and (6) monogamous married women. Participants expressed an intense interest in future HIV vaccine trials. Willingness to participate in future trials included altruism and the desire to have a protective vaccine for the future. Assurances regarding stigma and confidentiality, and compensation for families in the event of a poor outcome with a future HIV vaccine trial were reported. Concerns also centered on the impact of seroconverting, and a possible increase in risk behaviors. The need for education and counseling about the dangers of engaging in risky behavior during and after participating in a future HIV vaccine trial is discussed.

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supporting

confidence: 93%

Perceptions of a Community Sample about Participation in Future HIV Vaccine Trials in South India

et al. 2006

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“…Although no relationship was reported in several studies, some suggested that gender or educational level was associated with WTP (Lau & Wong, 2001;Meyers, Metzger, Navaline, Woody, & McLellan, 1994). Lower educational attainment was found to be related with greater willingness (Bartholow et al, 1997;Koblin et al, 1998;Perisse et al, 2000). Although in many developing countries there were concerns that women might be reluctant to be tested because of the fear of coping with a positive result (Temmerman, Ndinya-Achola, Ambani, & Piot, Bartholow et al (1997) to be more willing to participate in HIV vaccine trials.…”

Section: Introductionmentioning

confidence: 96%

“…A study among IDUs suggested that IDUs who shared needles were twice as likely to report WTP in a vaccine trial, whereas measures of risk sexual behaviors (e.g., multiple sexual partners, sex trade) in the prior 6 months were not related to WTP (Meyers et al, 1994). An HIV vaccine trial study revealed that participants who reported having an HIV-1-positive partner and MSM who reported unprotected receptive anal sex were significantly more likely to be willing to participate than those who did not report these behaviors, whereas those who shared needles/equipment among IDUs and women having unprotected vaginal sex were not associated with WTP (Koblin et al, 1998).…”

mentioning

confidence: 99%

Willingness to Participate in HIV/STD Prevention Activities among Chinese Rural-To-Urban Migrants

Yang

Li²,

Stanton³

et al. 2004

AIDS Education and Prevention

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Data from 4,208 migrants aged 18-30 years old in Beijing and Nanjing, China, were analyzed to examine the correlates of willingness to participate (WTP) in HIV/STD prevention intervention activities among Chinese rural-to-urban migrants. Overall, 83.3% of the respondents would be willing to participate. Increased WTP was associated with employment in the industrial sector (OR = 1.59, 95% CI: 1.11-2.29), migrating to cities to learn more about the outside world (OR = 1.31, 95% CI: 1.08-1.59), prior experience with health maintenance (OR = 1.36, 95% CI: 1.11-1.66), higher level of HIV/AIDS awareness (OR = 1.16, 95% CI: 1.02-1.31), and perceived severity of risk behaviors (OR = 1.32, 95% CI: 1.04-1.68). Decreased WTP was associated with increased involvement in health risk behaviors (OR = 0.50, 95% CI: 0.35-0.73), increased perceptions of peer risk involvement (OR = 0.81, 95% CI: 0.68-0.98), perceived intrinsic rewards for risk behaviors (OR = 0.81, 95% CI: 0.68-0.96) and perceptions of HIV-related stigma (OR = 0.68, 95% CI: 0.53-0.89). The high level of WTP suggests that HIV/STD prevention activities are acceptable among rural-tourban migrants. Their awareness of HIV/AIDS should be increased and HIV-related stigma should be reduced to increase the level of WTP. Recruitment and retention of individuals with high-risk behavior in prevention activities will be critical and challenging.Population mobility has been identified as a major risk factor for HIV/STD infection and transmission in many developing countries, including China (Bloom, Urassa, Isingo, Ng'weshemi & Boerma, 2002;Hope, 2000;Zhang & Ma, 2002 For any successful intervention, a prerequisite is that adequate numbers of individuals are willing to participate in it. Estimates of willingness to participate (WTP) will help researchers to determine the feasibility of prevention intervention program. Identification of associated factors may help to develop effective strategies to address those factors in the design and planning to increase WTP and, consequently, to improve participation rates.The issue of WTP in HIV-related programs was first addressed among intravenous drug users (IDUs) in the United States in the late 1980s (Magura et al., 1989;Marlink et al., 1987). During the past 2 decades, a growing number of studies addressing this issue have been reported among diverse populations, including men who have sex with men (MSM), bisexual men, pregnant women, and STD patients. Level of willingness and possible correlates (e.g., demographic characteristics, HIV/AIDS knowledge, health behaviors, and self-perceived susceptibility) have been examined in these studies. A broad range of willingness levels was reported among these varied populations. For example, among IDUs in methadone clinics, one study reported a WTP rate of 85% (39/46) for voluntary HIV testing, whereas another study found only a WTP rate of 38% (114/300) (Magura et al., 1989;Marlink et al., 1987). An international survey among pregnant women in 13 cities from nine developing countries r...

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“…[18][19][20][21][22][23] Findings show that WTP in a hypothetical HIVVT may be influenced by many factors. Among former participants (N52,531) in vaccine preparedness trials who were later invited to be screened for a phase 2 HIV vaccine trial, refusal to participate was higher among African Americans, and lower among people older than 40 years, having higher education, or reporting six or more sex partners in the prior six months.…”

mentioning

confidence: 99%

Breaking the Silence: What Homeless 18- to 24-Year-Olds Say about HIV Vaccine Trials

Koniak‐Griffin¹,

Nyamathi²,

Tallen³

et al. 2007

hpu

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Development of a global HIV vaccine will require enrollment of a large number of adults and adolescents in clinical trials. Involvement of homeless young adults in these trials will be particularly important because they often practice high-risk behaviors and are disproportionately infected by HIV. This qualitative study explores factors that might affect future participation of homeless 18-to 24-year-olds of diverse racial/ethnic backgrounds in HIV vaccine trials (HIVVTs). Twenty males and females attended focus groups. Participants expressed concern about seroconversion, the trustworthiness of the researchers and/or government agencies conducting trials, vaccine side effects, and possible negative behavior change as a result of being vaccinated. Understanding the personal perspectives of high-risk young adults will enable researchers to tailor protocols to their individual needs and cultural values and, in so doing, potentially enhance willingness to participate in HIVVTs.

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Readiness of high-risk populations in the HIV Network for Prevention Trials to participate in HIV vaccine efficacy trials in the United States

Abstract: It is likely that high-risk volunteers will be willing to enroll in HIV vaccine efficacy trials. A variety of participant and community educational strategies are needed to address participant concerns, and to ensure understanding of key concepts prior to giving consent for participation.

Cited by 126 publications

References 9 publications

Perceptions of a Community Sample about Participation in Future HIV Vaccine Trials in South India

Perceptions of a Community Sample about Participation in Future HIV Vaccine Trials in South India

Willingness to Participate in HIV/STD Prevention Activities among Chinese Rural-To-Urban Migrants

Breaking the Silence: What Homeless 18- to 24-Year-Olds Say about HIV Vaccine Trials

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