Readinbg of the lysine codons in the MS 2 coat protein cistron during protein synthesis in vitro

Elias, Per; Lustig, Florentyna; Axberg, Torsten; Bergt, Åkesson; Lagerkvist, Ulf

doi:10.1016/0014-5793(79)80171-4

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1980

1984

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Cited by 7 publications

References 19 publications

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“Two out of three” codon reading leading to mistranslation in vivo

Parker

Friesen

1980

Molec. Gen. Genet.

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Strains of Escherichia coli were starved for asparagine or lysine in order to increase the in vivo level of mistranslation. In a relA strain, asparagine starvation increased the error frequency in elongation factor Tu to 0.12 mistake per asparagine codon, while with lysine starvation in the same strain the error frequency per lysine codon was 0.008. The pattern of isoelectric point changes in the altered protein produced is consistent with third position misreading in the AAN codon group. This high level of mistranslation is not seen in streptomycin resistant (rpsL) strains or in most relA+ strains.

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“Two out of three” codon reading leading to mistranslation in vivo

Parker

Friesen

1980

Molec. Gen. Genet.

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Mistranslation in cells infected with the bacteriophage MS2: Direct evidence of Lys for Asn substitution

1980

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The coat protein of the bacteriophage MS2 was found to show an increased level of charge heterogeneity when synthesized in Escherichia coli starved for Asn or Lys. No such increase was found when the host was starved for Arg, His Ile or Pro. This is the pattern predicted by "two-out-of-three" codon misreading in the coat protein gene. In the case of Asn starvation, direct measurements of the relative incorporation of Lys demonstrate that the observed charge heterogeneity is the result of mistranslation. Asn starvation increased the error frequency in coat protein to over 0.3 mistake per asparagine codon. The small amount of charge heterogeneity seen in unstarved cells seems also to be the result of misreading Asn codons.

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C-A base pairs in transfer ribonucleic acids and codon-anticodon complexes

Mikelsaar¹

1981

Journal of Theoretical Biology

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Readinbg of the lysine codons in the MS 2 coat protein cistron during protein synthesis in vitro

Cited by 7 publications

References 19 publications

“Two out of three” codon reading leading to mistranslation in vivo

“Two out of three” codon reading leading to mistranslation in vivo

Mistranslation in cells infected with the bacteriophage MS2: Direct evidence of Lys for Asn substitution

C-A base pairs in transfer ribonucleic acids and codon-anticodon complexes

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