ReadiGraft BLX Putty and ReadiGraft Bone Chips in the Treatment of Severe Osteoarthropathy in Hemodialysed Patient.

Abstract

Osteoarticular complications are a major concern in patients treated with long-term hemodialysis, hemofiltration or continuous ambulatory peritoneal dialysis. Uremic chronic patients, treated for long periods of time (≥15 years) with hemodialysis, could develop a new kind of osteoarthropathy due to amyloidosis characterized by abnormal distribution of beta-2 microglobulin (B2M) in joint tissue. Deposits of B2M are responsible for several lesions, clinically evident in different pathologies, such as: carpal tunnel syndrome, spondylarthrosis, and hemodialysis osteoarthropathy.