Reader response: Practice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology

Braillon, Alain

doi:10.1212/wnl.0000000000006038

Cited by 125 publications

(221 citation statements)

References 4 publications

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“…As the "symptomatic predementia stage" (Langa and Levine, 2014), individuals with mild cognitive impairment (MCI) display mild impairment in cognitive function with preserved independent functional abilities and with no obvious deficits in social and occupational functioning (Albert et al, 2011). However, these individuals typically have a higher risk of dementia than age-matched individuals without MCI (Petersen et al, 2018;Aruanno and Garzotto, 2019). According to the World Health Organization, ∼47 million people worldwide are afflicted by dementia; this number is expected to increase to 75 million by 2030 and nearly 131 million by 2050 (Arvanitakis et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…According to the World Health Organization, ∼47 million people worldwide are afflicted by dementia; this number is expected to increase to 75 million by 2030 and nearly 131 million by 2050 (Arvanitakis et al, 2019). In people aged 60 years and older, the reported prevalence of MCI ranges from 6.7 to 25.2% (Petersen et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Important breakthroughs in the pharmacological treatment of dementia have not been achieved, resulting in gravitation toward non-pharmacological approaches (D'Cunha et al, 2018). Updated practice guidelines have noted that exercises (Level B) and cognitive interventions (Level C) may be beneficial to improve measures of cognitive function in patients with MCI (Petersen et al, 2018) and stress that exercise training for 6 months is likely to improve cognitive outcome (moderate confidence in the evidence based on two Class II studies).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Virtual Reality Intervention on Cognition and Motor Function in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis

Zhu

Sui

Shen

et al. 2021

Front. Aging Neurosci.

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Background: Virtual reality (VR) intervention is an innovative and efficient rehabilitative tool for patients affected by stroke, Parkinson's disease, and other neurological disorders. This meta-analysis aims to evaluate the effects of VR intervention on cognition and motor function in older adults with mild cognitive impairment or dementia.Methods: Seven databases were systematically searched for relevant articles published from inception to April 2020. Randomized controlled trials examining VR intervention in adults with mild cognitive impairment or dementia aged >60 years were included. The primary outcome of the study was cognitive function, including overall cognition, global cognition, attention, executive function, memory, and visuospatial ability. The secondary outcome was motor function, consisting of overall motor function, balance, and gait. A subgroup analysis was also performed based on study characteristics to identify the potential factors for heterogeneity.Results: Eleven studies including 359 participants were included for final analysis. Primary analysis showed a significant moderate positive effect size (ES) of VR on overall cognition (g = 0.45; 95% confidence interval (CI) = 0.31–0.59; P < 0.001), attention/execution (g = 0.49; 95% CI = 0.26–0.72; P < 0.001), memory (g = 0.57; 95% CI = 0.29–0.85; P < 0.001), and global cognition (g = 0.32; 95% CI = 0.06–0.58; P = 0.02). Secondary analysis showed a significant small positive ES on overall motor function (g = 0.28; 95% CI = 0.05–0.51; P = 0.018). The ES on balance (g = 0.43; 95% CI = 0.06–0.80; P = 0.02) was significant and moderate. The ES on visuospatial ability and gait was not significant. In the subgroup analysis, heterogeneity was detected in type of immersion and population diagnosis.Conclusions: VR intervention is a beneficial non-pharmacological approach to improve cognitive and motor function in older adults with mild cognitive impairment or dementia, especially in attention/execution, memory, global cognition, and balance. VR intervention does not show superiority on visuospatial ability and gait performance.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of Virtual Reality Intervention on Cognition and Motor Function in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis

Zhu

Sui

Shen

et al. 2021

Front. Aging Neurosci.

View full text Add to dashboard Cite

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“…Mild cognitive impairment (MCI) is characterized by a mild impairment of cognition, more than can be expected from age alone, at which daily functioning is largely unaffected (Petersen et al, 2014). The prevalence of MCI increases with age and varies between 6.7% in people aged 60-64 years and 25.2% for 80-84 years (Petersen et al, 2018). Older people with MCI are at higher risk for developing dementia, among which Alzheimer's disease (AD; Petersen et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of MCI increases with age and varies between 6.7% in people aged 60-64 years and 25.2% for 80-84 years (Petersen et al, 2018). Older people with MCI are at higher risk for developing dementia, among which Alzheimer's disease (AD; Petersen et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Chewing Efficiency, Global Cognitive Functioning, and Dentition: A Cross-sectional Observational Study in Older People With Mild Cognitive Impairment or Mild to Moderate Dementia

Delwel

Maier

Parvaneh

et al. 2020

Front. Aging Neurosci.

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Introduction: Previous studies suggest an association between poor mastication and cognitive impairment. The role of chewing efficiency and dentition in this relation is unclear. The aim was to examine global cognitive functioning and dentition as predictors for chewing efficiency, in older people with mild cognitive impairment (MCI) or dementia. Methods: In this observational cross-sectional study, 136 people with MCI or dementia were included. The chewing efficiency was assessed with a two-colored chewing gum and analyzed with the Chewing Efficiency Analysis software. The level of global cognitive functioning was measured with the Mini Mental State Examination (MMSE) by trained clinical staff. An oral examination was performed by a dentist and included the number of present teeth, the number of occluding pairs, and the presence of prostheses. Age, gender, and educational years were derived from the medical records. Univariate and multivariate backward stepwise linear regression analyses were used to evaluate global cognitive functioning and dentition as predictors for chewing efficiency. Results: The mean age of the participants was 82.1 (SD 5.8) years, and 74 (54.4%) were female. The participants had a median MMSE score of 22.4 (IQR 18.0-26.0) and a median Chewing Efficiency Analysis score of 0.46 (IQR 0.14-0.59). The median number of teeth was 13.0 (IQR 0.0-23.0), and the median number of occluding pairs was 0.0 (IQR 0.0-7.0). Sixty-four (47.4%) of the participants wore full prosthesis in the upper jaw. In univariate linear regression analyses, predictive factors for the Chewing Efficiency Analysis score were age, MMSE score, full prosthesis in the

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Associations of Multidomain Interventions With Improvements in Cognition in Mild Cognitive Impairment

et al. 2022

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Key Points Question Are multidomain interventions associated with better cognitive outcomes than single interventions in older adults with mild cognitive impairment (MCI)? Findings This meta-analysis of 28 studies with 2711 participants examined global cognition, attention, executive function, memory, processing speed, and verbal fluency effects. After intervention, significant improvements favoring multidomain interventions were observed in global cognition, executive function, memory, and verbal fluency compared with the single-intervention, active control. Meaning In this study, multidomain interventions were more strongly associated with improving global cognition, memory, executive function, and verbal fluency in older adults with MCI than single interventions, but evidence is needed to determine the optimal length of multidomain interventions.

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Reader response: Practice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology

Cited by 125 publications

References 4 publications

Effects of Virtual Reality Intervention on Cognition and Motor Function in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis

Effects of Virtual Reality Intervention on Cognition and Motor Function in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis

Chewing Efficiency, Global Cognitive Functioning, and Dentition: A Cross-sectional Observational Study in Older People With Mild Cognitive Impairment or Mild to Moderate Dementia

Associations of Multidomain Interventions With Improvements in Cognition in Mild Cognitive Impairment

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