Reactogenicity of infant whole cell pertussis combination vaccine compared with acellular pertussis vaccines with or without simultaneous pneumococcal vaccine in the Netherlands

David, Silke; Bondt, Patricia E. Vermeer-de; Maas, Nicoline A.T. van der

doi:10.1016/j.vaccine.2008.07.105

Cited by 37 publications

(35 citation statements)

References 16 publications

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“…12,13 Moreover, most of these studies used wP vaccines, which might induce a more prominent immunologic reaction than acellular vaccines, which typically exhibit lower reactogenicity regarding adverse events. 25 We found no differences in dispensed asthma medication, however, when comparing the 4 vaccines used in this trial, including 1 wP vaccine. To our knowledge, our study is the first to mainly investigate the effect of acellular pertussis vaccine on asthma medication on such a large scale.…”

Section: Discussionmentioning

confidence: 57%

Pertussis Immunization in Infancy and Adolescent Asthma Medication

2014

PEDIATRICS

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Section: Discussionmentioning

confidence: 57%

Pertussis Immunization in Infancy and Adolescent Asthma Medication

2014

PEDIATRICS

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“…However, currently, developed countries mainly use less reactogenic acellular pertussis vaccines. 26 Moreover, cancellation of vaccination increases the risk of a vaccine-preventable disease (eg, pertussis, measles). These diseases may also induce seizures or cause other, more severe complications.…”

Section: Figurementioning

confidence: 99%

“…However, the Dutch vaccine adverse event surveillance system has a very high reporting rate, with limited underreporting of severe adverse events such as seizures. 25,26 Further bias toward a specific subgroup is probably limited because of the high response rate, long prospective follow-up, similar length of initial follow-up, and similar delay in reporting the vaccinationrelated seizure in the 3 subgroups of epilepsy with vaccination-related onset.…”

Section: Figurementioning

confidence: 99%

Etiologies for Seizures Around the Time of Vaccination

et al. 2014

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OBJECTIVES: This study was an assessment of the incidence, course, and etiology of epilepsy with vaccination-related seizure onset in a population-based cohort of children. METHODS: The medical data of 990 children with seizures after vaccination in the first 2 years of life, reported to the National Institute for Public Health and Environment in the Netherlands in 1997 through 2006, were reviewed. Follow-up data were obtained of children who were subsequently diagnosed with epilepsy and had had seizure onset within 24 hours after administration of an inactivated vaccine or 5 to 12 days after a live attenuated vaccine. RESULTS: Follow-up was available for 23 of 26 children (median age: 10.6 years) with epilepsy onset after vaccination. Twelve children developed epileptic encephalopathy, 8 had benign epilepsy, and 3 had encephalopathy before seizure onset. Underlying causes were identified in 15 children (65%) and included SCN1A–related Dravet syndrome (formerly severe myoclonic epilepsy of infancy) or genetic epilepsy with febrile seizures plus syndrome (n = 8 and n = 1, respectively), a protocadherin 19 mutation, a 1qter microdeletion, neuronal migration disorders (n = 2), and other monogenic familial epilepsy (n = 2). CONCLUSIONS: Our results suggest that in most cases, genetic or structural defects are the underlying cause of epilepsy with onset after vaccination, including both cases with preexistent encephalopathy or benign epilepsy with good outcome. These results have significant added value in counseling of parents of children with vaccination-related first seizures, and they might help to support public faith in vaccination programs.

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“…Estudos prévios da vacina de células inteiras contra coqueluche relataram sobre eventos cardiorrespiratórios (ou seja, recorrência de apneia, bradicardia ou dessaturações de SpO 2 ) em recém-nascidos pré-termo [2][3][4][5][6] . Em estudos publicados recentemente, foi usada uma vacina acelular contra coqueluche, mas também foram relatadas reações adversas semelhantes [7][8][9][10][11][12] . A taxa de reações adversas teve grande variação entre os estudos (6% a 50%) 2,[11][12][13][14][15][16][17] .…”

Section: O Comitê Consultivo De Práticas De Imunização (Acip) Dosunclassified

“…Em estudos publicados recentemente, foi usada uma vacina acelular contra coqueluche, mas também foram relatadas reações adversas semelhantes [7][8][9][10][11][12] . A taxa de reações adversas teve grande variação entre os estudos (6% a 50%) 2,[11][12][13][14][15][16][17] . Estudos sugerem que recém-nascidos de muito baixo peso (RNMBP, peso ao nascer < 1.500 g) são um grupo de pacientes particularmente vulnerável ao desenvolvimento de reações adversas graves 8,15,16 .…”

Section: O Comitê Consultivo De Práticas De Imunização (Acip) Dosunclassified

Adverse cardiorespiratory events following primary vaccination of very low birth weight infants

Meinus¹,

Schmalisch²,

Hartenstein³

et al. 2012

J Pediatr (Rio J)

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Objective: To examine the relationship between primary vaccination of preterm infants and prevalence ratios of associated factors for unwanted cardiorespiratory events, following the recommendation of the Centers for Disease Control and Prevention Advisory Committee on Immunization Practices for immunization of preterm infants at 2 months of chronological age.Methods: Two-year retrospective study of very low birth weight infants receiving their primary vaccination. Major cardiorespiratory events, such as apnea, bradycardia, SpO 2 desaturation, and minor adverse events, such as temperature instability, poor handling and local reactions, were recorded. Prevalence ratio with 95% confidence interval for associated factors between infants with and without cardiorespiratory events was calculated.Results: Eighty neonates were studied (median [range] birth weight 970 g [428-1,490]), gestational age of 27.4 weeks (23.3-33). Adverse reactions occurred in 35 (44%) patients: minor events in 19 (24%), major events in 28 (35%). Infants with major events had significantly lower gestational age (p = 0.008) and a higher incidence of bronchopulmonary dysplasia (71% vs. 48%; p < 0.05). In very low birth weight infants with major events, O 2 desaturations before vaccination were 3.40 (1.41-8.23) times higher and treatment with methylxanthines for apnea and bradycardia syndrome was 8.05 (2.50-25.89) times higher compared to infants without major events. Conclusion:Major cardiorespiratory events occurred in over 1/3 of all very low birth weight infants after vaccination. Associated factors were low gestational age, bronchopulmonary dysplasia, methylxanthine treatment, and persisting O 2 desaturations before vaccination. Primary vaccination of very low birth weight infants should be performed under continuous monitoring of vital parameters. J Pediatr (Rio J)

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Reactogenicity of infant whole cell pertussis combination vaccine compared with acellular pertussis vaccines with or without simultaneous pneumococcal vaccine in the Netherlands

Cited by 37 publications

References 16 publications

Pertussis Immunization in Infancy and Adolescent Asthma Medication

Pertussis Immunization in Infancy and Adolescent Asthma Medication

Etiologies for Seizures Around the Time of Vaccination

Adverse cardiorespiratory events following primary vaccination of very low birth weight infants

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