Reactogenicity and Immunogenicity of Combined Haemophilus Influenzae Type B-Meningococcal Serogroup C Conjugate Vaccine Booster Dose Coadministered With Measles, Mumps, and Rubella Vaccinehib-Menc-Tt Booster With Routine MMR Vaccine

Abstract

A booster dose of Haemophilus influenzae type b-Neisseria meningitidis serogroup C conjugate (Hib-MenC-TT) vaccine simultaneously administered with measles, mumps, and rubella (MMR) vaccine in 13- to 14-month-old Spanish toddlers, primed with 3 doses of a combined Diphteria-Tetanus-Acellular Pertusis DTPa-Hib-containing vaccine and a MenC-CRM197 conjugate vaccine, had a good reactogenicity profile and induced similar Hib and MenC booster responses and MMR seropositivity rates as the vaccines given alone.

Conjugate Meningococcal Vaccines Development: GSK Biologicals Experience

“…The booster dose administered in the second year of life resulted in very high seroprotection rates against both Hib and MenC [68, 71, 73–75] (Table 2). After the booster vaccination, the percentages of Hib-MenC-TT primed children with anti-PRP ≥1.0  μ g/mL and rSBA-MenC titres ≥1 : 128 were 100% (data not shown) and 97.4–100% (Table 2), respectively.…”

“…Notably, no evidence of negative interference on the immune response to any of the antigens was observed when the Hib-MenC-TT vaccine was coadministered with common childhood vaccines including combined measles, mumps, and rubella vaccine [MMR], combined diphtheria, tetanus, acellular pertussis, and inactivated polio vaccine [DTPa-IPV], a combined diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus vaccine [DTPa-HBV-IPV], a 7-valent pneumococcal conjugate vaccine (7vCRM) and a 10-valent pneumococcal nontypeable H. influenzae protein D-conjugate vaccine [PHiD-CV] [62, 69, 71, 75, 80]. …”