Reactogenicidad de la vacuna Sputnik V en los estudiantes de medicina. Universidad de Carabobo

Abstract

Objective. To evaluate the reactogenicity of the SPUTNIK V vaccine in post-vaccinated 6th year Medicine students who carry out their care practices in the Autonomous Teaching Service of the Central Hospital of Maracay-Venezuela. Period February 2021- February 2022. Materials and methods. Prospective, evaluative, cross-sectional study. Medicine students were recruited, between 21 and 35 years of age who carried out their internships in the Autonomous Teaching Service of the Central Hospital of Maracay. The most important study variables were: The Sputnik V vaccine and the adverse reactions, evaluated using the anamnesis in an epidemiological consultation after the first 24 hours following the administration of the first dose, and 21 days later, 24 hours after the second dose of the vaccine in the same group. A medical file, validated by three experts, was used. Descriptive statistics, frequency tables and graphs were applied. Results. The predominant age group is between 21-25 years of age, 45 (81.82%) female, 37 (67.27%), 46 (83.67%) from the state of Aragua. The vaccination interval between doses was 3 weeks. The most frequent adverse reactions in the I dose: fever (83.64), malaise (58.18), headache (47.27) and myalgia (43.64%) that decreased significantly in the II dose. (16%) did not show reaction in I and (60%) in I. Conclusion. The post-vaccinated population is young. When receiving the first dose of the vaccine, more adverse reactions appeared than in the second. This is due to activation of the immune system (humoral response against COVID-19).