Reactivity to smoking cues: Mediating roles of nicotine dependence and duration of deprivation

Payne, Thomas J.; Smith, Patrick O.; Sturges, Lois V.; Holleran, Sharon A.

doi:10.1016/0306-4603(95)00043-7

Cited by 81 publications

(53 citation statements)

References 33 publications

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“…These findings suggest that higher levels of nicotine dependence may result in enhanced sensitivity to drug cues in these regions. Thus, they are consistent with previous reports of positive correlations between FTND scores and self-report cue reactivity (Payne et al, 1996) and analyses showing that highly dependent smokers are more sensitive to the conditioned aspects of smoking (Brauer et al, 2001). They are also consistent with previous reports of positive associations between sustained brain cue reactivity and nicotine dependence severity in cingulate gyrus (Smolka et al, 2006).…”

Section: Nicotine Dependencesupporting

confidence: 90%

“…Nicotine dependence is typically measured via self-report using measures such as the Fagerström test of nicotine dependence (FTND; Heatherton et al, 1991) and a number of studies have reported positive relations between FTND score and cue reactivity (Payne et al, 1996). However, some studies have not observed correlations between severity of nicotine dependence and cue-provoked craving (Waters et al, 2004) while others have found lighter smokers (with lower nicotine dependence scores) to exhibit greater attentional bias to smoking cues (Hogarth et al, 2003).…”

Section: Nicotine Dependencementioning

confidence: 99%

See 1 more Smart Citation

Individual Differences in Nicotine Dependence, Withdrawal Symptoms, and Sex Predict Transient fMRI-BOLD Responses to Smoking Cues

McClernon

Kozink

Rose

2007

Neuropsychopharmacol

190

146

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Exposure to smoking cues increases craving for cigarettes and can precipitate relapse. Whereas brain imaging studies have identified a distinct network of brain regions subserving the processing of smoking cues, little is known about the influence of individual difference factors and withdrawal symptoms on brain cue reactivity. Multiple regression analysis was used to evaluate relations between individual difference factors and withdrawal symptoms and event-related blood oxygen level-dependent responses to visual smoking cues in a sample of 30 smokers. Predictors were self-report nicotine dependence (Fagerströ m test of nicotine dependence, FTND), prescan withdrawal symptoms (craving and negative affect), and sex. The unique variance of each predictor was examined after controlling for each of the others. Positive associations were observed between FTND and reactivity to cues in right anterior cingulate and orbitofrontal cortex (OFC) whereas negative associations were observed between prescan craving and reactivity in ventral striatum. Higher negative affect or being male was associated with greater reactivity in left hippocampus and left OFC. Women exhibited greater cue reactivity than men in regions including the cuneus and left superior temporal gyrus. Individual difference factors and withdrawal symptoms were uniquely associated with brain reactivity to smoking cues in regions subserving reward, affect, attention, motivation, and memory. These findings provide further evidence that reactivity to conditioned drug cues is multiply determined and suggest that smoking cessation treatments designed to reduce cue reactivity focus on each of these variables.

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Section: Nicotine Dependencesupporting

confidence: 90%

Section: Nicotine Dependencementioning

confidence: 99%

Individual Differences in Nicotine Dependence, Withdrawal Symptoms, and Sex Predict Transient fMRI-BOLD Responses to Smoking Cues

McClernon

Kozink

Rose

2007

Neuropsychopharmacol

190

146

View full text Add to dashboard Cite

show abstract

“…This effect was reported by Payne et al (1996) and observed in our earlier study (Powell et al 2002a) consistent with priming studies, which have demonstrated inflated desire for, or use of, a drug following a small dose of the same or another drug (e.g. Spiga et al 1998 …”

supporting

confidence: 90%

“…Some data consistent with this hypothesis have been reported (Powell et al 2002a;Payne et al 1996). By contrast, others (e.g.…”

Section: Discussionmentioning

confidence: 66%

A double-blind placebo controlled experimental study of nicotine: I—effects on incentive motivation

et al. 2006

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“…Whereas some studies have found no effect of abstinence on cue-elicited craving or physiological responses (e.g., Drobes and Tiffany 1997), in a study by Payne et al (1996) cue-elicited increases in craving were greater within 90 min of smoking than after 180 min of abstinence, despite the fact that preexposure craving was not at ceiling.…”

Section: Smoking-related Stimuli Will Elicit Greater Increases In Submentioning

confidence: 81%

Smoking, reward responsiveness, and response inhibition: tests of an incentive motivational model

Powell

Dawkins

Davis

2002

Biological Psychiatry

126

114

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Background: Incentive-motivation models of addiction suggest impairment of functional activity in mesocorticolimbic reward pathways during abstinence. This study tested implications for subjective and behavioral responses to nondrug incentives, cue-elicited craving, and prefrontal cognitive functions, particularly response inhibition. Methods:We tested 26 smokers after smoking and after overnight abstinence in counterbalanced order; 26 nonsmokers were also tested twice. Measures included a simple card-sorting test performed with and without financial incentive (the CARROT), the Snaith Hamilton Pleasure Scale as an index of subjective reward responsiveness, ratings of subjective craving and withdrawal before and after exposure to a cigarette, an index of oculomotor response inhibition (saccadic vs. antisaccadic eye movements), verbal fluency, and reversed digit span. Results:Compared with the smoking condition, and independently of withdrawal severity, abstinence was associated with reduced cue reactivity, pleasure expectancies, responsiveness to financial incentive, and response inhibition (antisaccadic eye movements). Verbal fluency and reversed digit span were unaffected, contrary to findings elsewhere with heavier smokers. Nonsmokers' scores either fell between those of abstainers and recent smokers or approximated those of recent smokers. Conclusions:The data were in general consistent with behavioral predictions derived from the incentive-motivational model of addiction and suggest that abstinence may be associated with impairments of motivation and response inhibition, which are independent of other subjectively experienced withdrawal symptoms.

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Reactivity to smoking cues: Mediating roles of nicotine dependence and duration of deprivation

Cited by 81 publications

References 33 publications

Individual Differences in Nicotine Dependence, Withdrawal Symptoms, and Sex Predict Transient fMRI-BOLD Responses to Smoking Cues

Individual Differences in Nicotine Dependence, Withdrawal Symptoms, and Sex Predict Transient fMRI-BOLD Responses to Smoking Cues

A double-blind placebo controlled experimental study of nicotine: I—effects on incentive motivation

Smoking, reward responsiveness, and response inhibition: tests of an incentive motivational model

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