Reactivity to human papillomavirus type 16 L1 virus-like particles in sera from patients with genital cancer and patients with carcinomas at five different extragenital sites

Doornum, G. J. J. Van; Korse, Catharina M.; Buning-Kager, Johanna C.G.M.; Bonfrèr, Johannes M.G.; Horenblas, Simon; Taal, B.G.; Dillner, Joakim

doi:10.1038/sj.bjc.6600870

Cited by 53 publications

(48 citation statements)

References 53 publications

(57 reference statements)

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“…The risk ratio confidence intervals for the association of HPV 16 and ESCC in the other previous studies were 1.8-11.9, 10 1.0-510, 9 0.5-2.0 11 and 0.3-2.0. 12 Several of these CIs are very wide, indicating unstable risk estimates. All of these CIs overlap those obtained in our study (0.8-3.3).…”

Section: Discussionmentioning

confidence: 99%

“…10 In contrast, the other 2 retrospective studies, both conducted in Europe, found no association between HPV 16 and the risk of ESCC: Lagergren et al found an OR of 1.0 (0.5-2.0), and Van Doornum et al found an OR of 0.8 (0.3-2.0). 11,12 Four of these serologic studies also examined the association between HPV 16 and the risk of esophageal or gastric adenocarcinoma (Table V). None of these studies found a significant association between HPV 16 and these cancers.…”

Section: Discussionmentioning

confidence: 99%

“…Four of the seroepidemiological studies that evaluated the association between HPV and ESCC also reported data on its association with esophageal adenocarcinomas, gastroesophageal junction adenocarcinomas, or gastric adenocarcinomas. 8,9,11,12 None of these studies found a significant association between HPV 16 and these cancers. Lagergren et al found an inverse association between HPV 18 and adenocarcinomas of the esophagus or gastroesophageal junction (OR 0.2, 95% CI 0.1-0.7).…”

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confidence: 95%

“…9 The results of 1 of the retrospective serologic studies also showed a significant 4.5-fold increase in the risk of ESCC associated with seropositivity to HPV 16, 10 but the 2 other studies did not show any increased risk. 11,12 Two of these serologic studies, 1 prospective and 1 retrospective, also examined the relationship of HPV 18 seropositivity and ESCC, but found no significant association. 9,11 HPV 73 has been reported to be the most common type of HPV found in benign and malignant esophageal tumors.…”

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confidence: 99%

“…6 Seroreactivity to HPV 16 is a strong marker of continuous past exposure to HPV 16 and is associated with squamous intraepithelial lesions of the uterine cervix. 6,7 So far 5 seroepidemiological studies, 2 prospective 8,9 and 3 retrospective (casecontrol), [10][11][12] have examined the association of anti-HPV 16 IgG antibodies with the risk of ESCC. Both prospective studies found a strong positive association between HPV 16 and ESCC.…”

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Human papillomavirus serology and the risk of esophageal and gastric cancers: Results from a cohort in a high‐risk region in China

Kamangar

Qiao

Schiller

et al. 2006

Intl Journal of Cancer

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Each year, esophageal and gastric cancers cause more than 900,000 deaths worldwide. Human papilloma virus (HPV), especially type 16, has been suggested to have a role in the etiology of esophageal cancer, however, the results of previous seroepidemiological studies have not been consistent. We conducted a large prospective study to examine the association between serum antibodies to HPV 16, HPV 18 and HPV 73 and subsequent development of esophageal squamous cell carcinoma (ESCC), gastric cardia adenocarcinoma (GCA), and gastric noncardia adenocarcinoma (GNCA) in a high-risk population for these cancers in Linxian, China. Case and control subjects for this study were selected from the 29,584 participants of the Linxian General Population Trial. Prediagnostic serum samples from 99 cases of ESCC, 100 cases of GCA, 70 cases of GNCA, and 381 age-and sex-matched controls were selected for this study. The presence of antibodies to HPV virus-like particles was determined by type-specific enzyme-linked immunosorbent assays. Fewer than 15% of ESCC, GCA, or GNCA cases were positive for each HPV type, and no significant associations were found. The adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for HPV 16 seropositivity and ESCC, GCA, and GNCA risk were 1.6 (0.8-3.3), 1.3 (0.6-2.8) and 0.4 (0.1-1.6), respectively. The comparable ORs (95% CIs) for HPV 18 were 1.0 (0.4-2.2), 0.9 (0.4-2.1) and 1.5 (0.6-3.4). For HPV 73, these figures were 1.3 (0.6-2.5), 1.2 (0.6-2.3) and 0.9 (0.4-2.1). The results of this study do not support a major role for HPV 16, HPV 18 and HPV 73 in the etiology of esophageal and gastric cancers in Linxian, China. ' 2006 Wiley-Liss, Inc.Key words: esophageal cancer; human papillomavirus; serology Oncogenic types of human papillomavirus (HPV), most notably HPV 16 and HPV 18, are recognized as the most significant risk factors for cervical cancer. 1 The role of HPV in the etiology of cancers of vulva, anus, penis and oropharyngeal cavity has also been established. 2 The role of HPV in the etiology of esophageal cancer, however, remains controversial. Syrjanen first suggested a role for HPV in the etiology of esophageal squamous cell carcinoma (ESCC) in 1982, based on observing characteristic histological findings suggesting the presence of HPV in benign esophageal epithelia and malignant esophageal tumors. 3 During the past 20 years, several studies have used a variety of techniques, including detection of HPV DNA in esophageal tumor tissues and serologic methods, to examine the association between exposure to HPV and risk of ESCC. 4 The results of HPV DNA studies have not been consistent: case series using polymerase chain reaction (PCR) have found evidence for the presence of HPV in the tumor tissues varying from 0 to 67%. 4 Type-restricted serologic assays for different HPV types using virus-like particles were first developed in the mid-1990s, 5 and were subsequently shown to be relatively specific for each HPV type. 6 Seroreactivity to HPV 16 is a strong marker of continuous past exp...

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Human papillomavirus serology and the risk of esophageal and gastric cancers: Results from a cohort in a high‐risk region in China

Kamangar

Qiao

Schiller

et al. 2006

Intl Journal of Cancer

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Male Genital Tract

Henley¹,

Ulbright²

2007

The Cancer Handbook

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Tumours of the male genital tract, including those of the prostate gland, testis, and penis, are a significant cause of morbidity and mortality. In western culture, aside from skin tumours, prostate cancer is the most common type of cancer found in men. In male adolescents and young adults germ cell tumours of the testis are the most common type of solid tumour cancer. Carcinoma of the penis, although uncommon in the industrialized world, accounts for up to 20% of male malignancies in less developed parts of the world. The epidemiology and pathology of these diseases have become well characterized. Applied immunohistochemical and in situ hybridization techniques continue to refine pathologic classification and diagnosis. Aetiologies, unfortunately, remain elusive. Undoubtedly, the accumulating wealth of data on genes and proteins will eventually unravel the molecular pathogenesis of these tumours. Continued progress will see application of these data to aid prevention, assessment of prognosis, and treatment.

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Tumors of the Esophagus

Gonzalez

Lightdale

2012

The Esophagus

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Reactivity to human papillomavirus type 16 L1 virus-like particles in sera from patients with genital cancer and patients with carcinomas at five different extragenital sites

Cited by 53 publications

References 53 publications

Human papillomavirus serology and the risk of esophageal and gastric cancers: Results from a cohort in a high‐risk region in China

Human papillomavirus serology and the risk of esophageal and gastric cancers: Results from a cohort in a high‐risk region in China

Male Genital Tract

Tumors of the Esophagus

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