Reactivity Studies and Synthetic Strategies Towards the Preparation of New Hydrophilic Indirubin-Triazole-Based Compounds
Ana Flávia Fuzaro,
Frederico Henrique Ferreira,
Gabriela Suhett
et al.
Abstract:Indirubin is an isomer of the blue dye indigo. It is widely used in Chinese medicine as part of therapy against many diseases and, thus, its skeleton becomes a promising candidate for new drug prototypes. Since it has low solubility, its properties could be improved through the insertion of hydrophilic and pharmacophoric groups, such as sugars bridged to 1,2,3-triazoles. Here, we report the synthesis of indirubin-based compounds evaluating two different routes: via the aldol condensation reaction of triazole-i… Show more
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