Reactivity of Blood Vessels in the Sympathectomized Human Leg

Effect of adrenaline and noradrenaline on blood vessels of the hand before and after sympathectomy

“…In laboratory animals the amount of sensitivity has been commonly thought to be greater after postganglionic denervation than after preganglionic decentralization (LeCompte, 1941;Cannon & Rosenblueth, 1949). In man, however, the assumption that ganglionectomy causes more sensitivity has been challenged (Fatherree & Allen, 1938;Millonig, Harris & Gardner, 1950;Stein et al 1949;Duff, 1952Duff, , 1953 and the present results further conflict with that assumption.…”

“…VASCULAR SENSITIVITY AFTER SYMPATHECTOMY 61 Information on the actual incidence of sensitivity following either type of sympathectomy in man is scanty but a failure to detect changes in a proportion of subjects has been noted (Stein, Harpuder & Byer, 1949). In laboratory animals the amount of sensitivity has been commonly thought to be greater after postganglionic denervation than after preganglionic decentralization (LeCompte, 1941;Cannon & Rosenblueth, 1949).…”

Effect of Surgical Sympathectomy on the Sensitivity to Epinephrine of the Blood Vessels of Muscular Segments of the Limbs 12

“…-In a study of the circulatory differences between hands and forearms it was incidentally noted by Grant and Pearson (7) that the dilator response of the forearm to epinephrine was increased in one patient following sympathectomy. In patients with peripheral arterial disease sensitization of the muscle vessels of the lower limb has been reported to follow preganglionic section (8).…”

Cardiovascular Effects of Extradural Analgesia in Labour: Comparison of Bupivacaine With Lignocaine

“…Low concentrations of adrenaline stimulate (3 -receptors in the heart and arterial walls (Green and Kepchar, 1959;Goodman and Gillman, 1970) and a-receptors in the veins (Green and Kepchar, 1959;Wood, 1965). However, in vessels in which the sympathetic innervation has been interrupted surgically, the P-effects of adrenaline are enhanced (Stein, Harpuder and Byer, 1949). As a sympathetic block always accompanies extradural analgesia the total venous response is the result of a balance between a-and p-effects.…”