“…NHC gold carbene complexes have become state of the art over the last decade, with numerous applications in the medicinal field [ 150 ]. Acyclic carbene (ACC) ligands, on the other hand, present a promising alternative due to their synthetic versatility, and they provide a variety of methods to improve solubility, cell uptake, and selectivity of cytotoxicity [ 151 , 152 , 153 ]. Some of the first examples of this category are the acyclic carbene adducts of gold; however, their biological impact is as yet hardly explored [ 148 , 154 ].…”