Reactive sulfur species inhibit the migration of PDGF-treated vascular smooth muscle cells by blocking the reactive oxygen species-regulated Akt signaling pathway

Ishii, Shunichi; Ashino, Takashi; Fujimori, Hiroki; Numazawa, Satoshi

doi:10.1080/10715762.2021.1887485

Cited by 3 publications

(2 citation statements)

References 45 publications

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“…However, sodium tetrasulfide, which is also a sulfane sulfur donor, was reported to persulfidate proteins within the cell; although the most common function of the target proteins was "transcription", a wide range of other proteins were persulfidated by sodium tetrasulfide [29][30][31][32][33]. Additionally, platelet-derived growth factor (PDGF) increased cellular sulfane sulfur, and tetrasulfide inhibited vascular smooth muscle cell migration through the Akt pathway activated by PDGF-induced ROS production [34], suggesting that there are cell type-dependent systems that regulate RSS production. Thus, TGF-β 1 likely increases the persulfidation of cellular proteins that positively regulate vascular endothelial cell proliferation to modulate the inhibitory effect of TGF-β 1 on proliferation.…”

Section: Discussionmentioning

confidence: 99%

Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-β1: Induction of Cystathionine γ-Lyase and Cystathionine β-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways

Takahashi

Fujie

Nakano

et al. 2021

IJMS

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Transforming growth factor-β1 (TGF-β1) occurs at high levels at damage sites of vascular endothelial cell layers and regulates the functions of vascular endothelial cells. Reactive sulfur species (RSS), such as cysteine persulfide, glutathione persulfide, and hydrogen persulfide, are cytoprotective factors against electrophiles such as reactive oxygen species and heavy metals. Previously, we reported that sodium trisulfide, a sulfane sulfur donor, promotes vascular endothelial cell proliferation. The objective of the present study was to clarify the regulation and significance of RSS synthesis in vascular endothelial cells after exposure to TGF-β1. Bovine aortic endothelial cells in a culture system were treated with TGF-β1 to assess the expression of intracellular RSS, the effect of RSS on cell proliferation in the presence of TGF-β1, induction of RSS-producing enzymes by TGF-β1, and intracellular signal pathways that mediate this induction. The results suggest that TGF-β1 increased intracellular RSS levels to modulate its inhibitory effect on proliferation. The increased production of RSS, probably high-molecular-mass RSS, was due to the induction of cystathionine γ-lyase and cystathionine β-synthase, which are RSS-producing enzymes, and the induction was mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 pathways in vascular endothelial cells. TGF-β1 regulates vascular endothelial cell functions such as proliferation and fibrinolytic activity; intracellular high-molecular-mass RSS, which are increased by TGF-β1, may modulate the regulation activity in vascular endothelial cells.

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Section: Discussionmentioning

confidence: 99%

Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-β1: Induction of Cystathionine γ-Lyase and Cystathionine β-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways

Takahashi

Fujie

Nakano

et al. 2021

IJMS

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“…RSS give full play to superiority in adjusting redox activity [1] and maintaining mitochondrial health [2]. However, RSS disorders can also induce a variety of diseases such as arteriosclerosis [3], diabetes [4],…”

Section: Introductionmentioning

confidence: 99%

Molecular Engineering of Benzenesulfonyl Analogs for Visual Hydrogen Polysulfide Fluorescent Probes Based on Nile Red Skeleton

Wu¹,

Qian²,

Song³

et al. 2022

Preprint

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Molecular engineering of benzenesulfonyl analogs for visual hydrogen polysulfide fluorescent probes based on Nile red skeleton

Qian

Song

et al. 2023

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Reactive sulfur species inhibit the migration of PDGF-treated vascular smooth muscle cells by blocking the reactive oxygen species-regulated Akt signaling pathway

Cited by 3 publications

References 45 publications

Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-β1: Induction of Cystathionine γ-Lyase and Cystathionine β-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways

Synthesis of Reactive Sulfur Species in Cultured Vascular Endothelial Cells after Exposure to TGF-β1: Induction of Cystathionine γ-Lyase and Cystathionine β-Synthase Expression Mediated by the ALK5-Smad2/3/4 and ALK5-Smad2/3-ATF4 Pathways

Molecular Engineering of Benzenesulfonyl Analogs for Visual Hydrogen Polysulfide Fluorescent Probes Based on Nile Red Skeleton

Molecular engineering of benzenesulfonyl analogs for visual hydrogen polysulfide fluorescent probes based on Nile red skeleton

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