Reactive seizures in cats: A retrospective study of 64 cases

Kwiatkowska, M.; Hoppe, Susanne; Pomianowski, A.; Tipold, Andrea

doi:10.1016/j.tvjl.2018.11.009

Cited by 10 publications

(10 citation statements)

References 21 publications

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“…The onset profile of chronic disorders during the study period in the no beraprost therapy group was mostly consistent with the record of baseline coexisting disorders in the present study; however, there were some differences in that neuromuscular disorders such as epilepsy and seizures were newly observed and that cardiovascular disorders were increased, during the study. Epilepsy and seizures in cats with CKD can be caused by uremic encephalopathy; it is reported that all cats with renal encephalopathy had IRIS stage 3 or 4 CKD with mean creatinine of 2.9 mg/dL (40). Cardiovascular-renal disorders (CvRD) is the pathophysiological relationship between the kidney and heart in disease, and kidney injury is proposed to be able to lead to systemic volume overload that contributes to congestion, especially in animals with coexisting cardiac disease including cardiomyopathy (3); these factors could have influenced the results.…”

Section: Discussionmentioning

confidence: 99%

Beraprost and Overall Survival in Cats With Chronic Kidney Disease

Ito¹,

Matsuura²,

Sano³

2023

Preprint

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Background: Overall survival is the most important outcome for treatment response in feline chronic kidney disease (CKD). Beraprost has been shown to reduce the kidney function decline in cats with International Renal Interest Society (IRIS) stage 2 and 3 CKD. However, association with prolonged survival has not yet been examined. Objective: To assess the relationship between beraprost and overall survival in cats with CKD in real clinical practice. Animals: Client-owned cats with IRIS stage 3 CKD (n = 134), evaluated between 2017 and 2020. Methods: Retrospective cohort study based on data from electronic medical records of one hospital. Results: Multivariable Cox regression models on all treatment effects showed that beraprost only was related to better survival (P = 0.028). The cohort was divided into “beraprost therapy” and “no beraprost therapy” groups, and survival analyses revealed that overall survival was significantly longer in the beraprost therapy group, using Kaplan-Meier curves (P = 0.004). However, baseline phosphate is known to be an important prognostic indicator and was not well balanced between the two groups. Therefore, a subcohort of 97 cats was selected (those having baseline phosphate < 6.0 mg/dL) that allowed for this parameter to be balanced between groups. The survival data in this subcohort was consistent with that of the overall study cohort. Conclusions: In feline patients with CKD, beraprost therapy was associated with better overall survival.

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Section: Discussionmentioning

confidence: 99%

Beraprost and Overall Survival in Cats With Chronic Kidney Disease

Ito¹,

Matsuura²,

Sano³

2023

Preprint

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“…[17][18][19] A recent study identified SH in 8.1% of cats presented with reactive seizures. 20 SH-associated neurological abnormalities suggesting increased intracranial pressure include obtundation, depression, photophobia and focal facial or generalized seizures, 6,14,17,19 representing 14% of studied cases. 14 Haemorrhagic myelomalacia of the lumbosacral region of the spinal cord has been described in a hyperthyroid cat with uncontrolled SH.…”

Section: Introductionmentioning

confidence: 99%

“…Hypertensive cats with neurological signs are presented less frequently, although the current incidence of neurological dysfunction may be underestimated 17–19 . A recent study identified SH in 8.1% of cats presented with reactive seizures 20 . SH‐associated neurological abnormalities suggesting increased intracranial pressure include obtundation, depression, photophobia and focal facial or generalized seizures, 6,14,17,19 representing 14% of studied cases 14 .…”

Section: Introductionmentioning

confidence: 99%

Severity of neurological signs in feline hypertensive encephalopathy may be reflected through brain histopathological lesions

Baka

Soubasis

Oevermann

et al. 2021

Vet Record Case Reports

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Hypertensive encephalopathy (HE) was diagnosed in two aged cats with chronic kidney disease. The cause for admission was generalised epileptic seizures, with severe, interictal neurological dysfunction (dementia, locomotor dysfunction, cranial nerve deficits). Both cats had systolic hypertension (SH) (180‐220 mm Hg), bilateral retinal detachment, non‐regenerative anaemia and moderate renal azotaemia. Both cats died. Gross lesions were apparent in one cat consisting of white matter oedema in the parietal and temporal lobe and a focal area of malacia. Histopathological examination of brain tissue revealed bilateral severe oedema and astrocytic gliosis in the corona radiata, basal nuclei, thalamus and piriform lobe of both cats. Extensive hyaline and hyperplastic arteriolosclerosis, perivascular plasma exudation and haemorrhages were present throughout the meninges and neuroparenchyma. Histopathological findings reflected the severity of neurological deficits. This could indicate that the severity of the brain lesions is associated with the neurological manifestations of HE.

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“…

A 4 year old spayed female domestic short-haired cat presents to your emergency room with seizures and hypersalivation. The owners described the first episode of seizures occurring almost 3 hours after applying a permethrin spot-on (PSO) product with a formulation higher than ≈ 45% directly on their cat's coat.This scenario is common in emergency rooms, as owners do not know that permethrin-based products intended to control ectoparasites in dogs should not be used in cats [1][2][3][4][5] . These highly concentrated formulations

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mentioning

confidence: 99%

“…This scenario is common in emergency rooms, as owners do not know that permethrin-based products intended to control ectoparasites in dogs should not be used in cats [1][2][3][4][5] . These highly concentrated formulations…”

mentioning

confidence: 99%

Is soybean therapy better than ClinOleic for reducing recovery time in cats with permethrin toxicosis?

Gordon

2021

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PICO question Is soybean oil-based intravenous lipid emulsion (IVLE) therapy more effective than olive oil-based (ClinOleic IVLE therapy) for reducing time to recovery in cats with permethrin toxicosis? Clinical bottom line Category of research question Treatment The number and type of study designs reviewed Five case reports and one randomised clinical trial Strength of evidence Weak Outcomes reported Soybean oil-based and ClinOleic IVLE therapies can be used safely as adjuvant treatments to reduce time to recovery in cats with permethrin intoxication. However, the evidence collected suggests that soybean oil-based IVLE therapy is better in reducing the recovery time after permethrin toxicosis as compared to ClinOleic IVLE therapy Conclusion The overall findings showed that the average recovery time after soybean oil-based IVLE therapy across patients with permethrin intoxication was 8.5 hours and the average time to recovery after olive oil-based emulsions (ClinOleic therapy) was 39 hours. This may suggest that soybean oil-based formulations are a better option for reducing the recovery time in cats after permethrin toxicity. Dermal decontamination, supportive care, muscle relaxers, and anticonvulsant drugs are examples of recommended treatments before the administration of any intralipid therapies and must be used based on the clinical signs of each patient How to apply this evidence in practice The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources. Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.

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Reactive seizures in cats: A retrospective study of 64 cases

Cited by 10 publications

References 21 publications

Beraprost and Overall Survival in Cats With Chronic Kidney Disease

Beraprost and Overall Survival in Cats With Chronic Kidney Disease

Severity of neurological signs in feline hypertensive encephalopathy may be reflected through brain histopathological lesions

Is soybean therapy better than ClinOleic for reducing recovery time in cats with permethrin toxicosis?

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